Article
Spectroscopy
Wichit Taron, Wassana Jamnongkan, Jutarop Phetcharaburanin, Poramate Klanrit, Nisana Namwat, Anchalee Techasen, Paiboon Sithithaworn, Narong Khuntikeo, Thidarut Boonmars, Watcharin Loilome, Wittaya Ngeontae
Summary: The development of a new fluorescence AuNPs-LISA technique utilizing OPD as a chromogenic substrate and incorporating the non-ionic surfactant Triton X-100 has significantly enhanced the detection sensitivity for OvAg concentration, leading to a 1200-fold improvement compared to the colorimetric AuNPs-LISA. The proposed assay demonstrates high diagnosis sensitivity, specificity, and accuracy, providing a promising tool for the detection, control, and elimination of human opisthorchiasis in endemic areas.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Nanoscience & Nanotechnology
Xingzhen Li, Lei Pan, Fan Yang, Liang Yang
Summary: In this study, a portable smartphone platform based on ratiometric fluorescent nanoprobes was designed for the rapid, real-time, and sensitive detection of copper ions in tea and tea beverages. The method showed high sensitivity, good selectivity, and strong anti-interference ability. The combination of the fluorescent nanoprobes and smartphones allowed for visual analysis and provided a convenient method for on-site and visual inspection of tea and tea beverages.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biophysics
Qiangqiang Fu, Tao Qi, Ze Wu, Yongjian He, Shujuan Guan, Shihua Luo, Qi Zhang, Wenfeng Luo, Wei Xiao, Bo Situ, Lei Zheng
Summary: This study presents a portable and affordable smartphone-based Hb analyzer for quick anemia testing, especially suitable for high-risk patients in areas with limited medical resources.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Visarute Pinrod, Wireeya Chawjiraphan, Khoonsake Segkhoonthod, Kriangkai Hanchaisri, Phornpol Tantiwathanapong, Preedee Pinpradup, Thitirat Putnin, Dechnarong Pimalai, Kiatnida Treerattrakoon, Ubon Cha'on, Sirirat Anutrakulchai, Deanpen Japrung
Summary: This study presents the development of a portable fluorometer with a smartphone application designed for the early screening of kidney diseases. The device achieved a linear calibration curve and a detection limit for human serum albumin, and demonstrated comparable performance with a commercial fluorometer and the standard automated method when analyzing 130 urine samples. These findings validate the feasibility and reliability of the portable fluorometer and aptasensor combination.
Article
Chemistry, Analytical
Chaonan He, Xiaorong Liu, Mengmeng Yu, Zhuang Qiu, Tong Huang, Weichang Xie, Haoxin Cheng, Yifei Yang, Xian Hao, Xiaolei Wang
Summary: A portable platform for quantitative detection of viral DNA based on fluorescence resonance energy transfer (FRET) principle is constructed using upconversion nanoparticles (UCNPs) and graphene oxide nanosheets (GOs). The sensitivity and detection limit are improved by modifying GOs with magnetic nanoparticles to prepare magnetic graphene oxide nanosheets (MGOs). A carrier chip based on photonic crystals (PCs) is introduced to achieve visual solid-phase detection and amplify the luminescence intensity. With the 3D printed accessory and smartphone program, this portable detection provides a high-quality viral detection strategy and clinical diagnosis method.
Article
Chemistry, Analytical
Denis Omael Silva Pereira, Mariana Mourao Matos, Alexandre Fonseca
Summary: This work describes the construction and evaluation of a fluorometer for use in paper analytical devices, using a smartphone to operate the instrument and to perform real-time image-based detection. The performance of the fluorometer was evaluated for the determination of quinine in beverages and riboflavin (B2 vitamin) in supplements. Linear calibration ranges were observed for both analytes, and successive additions of standard solutions to a single analytical plate of PAD enhanced the signal-to-noise ratios for less concentrated samples.
ANALYTICAL METHODS
(2023)
Article
Engineering, Environmental
Jie Cao, Yingying Liu, Shiquan Xiong, Qiao Cao, Shihao Xu, Changlong Jiang
Summary: A new probe solution and test paper have been developed for visual detection of ammonium, which can perform colorimetric change for high-concentration ammonium and ratiometric fluorescence response for low-concentration ammonium. It has great application potential for on-site detection of ammonium in environmental samples.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Physical
Kisoo Kim, Won Gu Lee
Summary: This article highlights the urgent demand for portable diagnostic systems to prevent and control pandemics globally, and the significance of smartphone-based portable diagnostic devices. It also emphasizes the role of deep learning algorithms in enhancing diagnostic accuracy, and discusses the challenges and prospects of portable optical systems in screening COVID-19.
Review
Oncology
Su Min Cho, Abdullah Esmail, Ali Raza, Sunil Dacha, Maen Abdelrahim
Summary: Cholangiocarcinoma accounts for approximately 3% of gastrointestinal malignancies globally, with mortality rates on the rise in recent years. Targeted therapies, known for their specificity towards cancer cells, have only recently gained FDA approval for the treatment of cholangiocarcinoma.
Article
Chemistry, Analytical
Jiaheng Zhang, Jun Wang, Feijun Ouyang, Zhi Zheng, Xiaowan Huang, Haitao Zhang, Dongxiu He, Suisui He, Hua Wei, Cui-Yun Yu
Summary: The emergence of superbugs due to antibiotics overuse poses a significant threat to human health and security. Hence, the development of sensitive and effective antibiotics detection is necessary. In this study, a rapid and instrument-free detection method for antibiotic residues was developed using a ratiometric fluorescence sensing platform.
ANALYTICA CHIMICA ACTA
(2023)
Article
Oncology
Yang Yang, Jinyan Yuan, Zhenzhong Liu, Wenwen Cao, Pei Liu
Summary: CCA patients with high expression of HJURP have lower overall survival rates, specifically in iCCA and pCCA. HJURP serves as an independent prognostic biomarker in iCCA and pCCA, but not in dCCA. This study provides further evidence of the molecular features of different CCA subsets and suggests that HJURP can guide precision follow-up and treatment for CCA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Analytical
Rishi Ram, Dharmendra Kumar, Arnab Sarkar
Summary: A simple, affordable, and portable spinning disc has been developed for measuring creatinine concentration. The device shows high correlation with the gold standard device and can be used in resource-constrained settings to monitor renal diseases.
Article
Chemistry, Applied
Chunhua Li, Xiao Xu, Fuli Wang, Yue Zhao, Yubo Shi, Xin Zhao, Jue Liu
Summary: In this study, a smart point-of-care (SPOC) sensor was developed for ultrasensitive and visual quantitative detection of ascorbic acid (AA) in food. The sensor consists of a fluorescent paper chip, 3D printed-accessories and a smartphone, and exhibits high sensitivity with low detection limits.
Article
Chemistry, Analytical
Meng Wu, Ting Liu, Chenhui Yin, Xinxin Jiang, Qijun Sun, Lei Gao, Na Niu, Ligang Chen, Huixin Gang
Summary: In this study, a smartphone-assisted RGB-dependent TC-PBQ ratiometric sensing platform was introduced for rapid recognition. The red-emitting mercaptopropionic acid-capped CdTe quantum dots can be quenched by TC-PBQ, while the blue-emitting carbon dots as the reference signal remain unchanged. The sensing platform has a limit of detection of 59 nM in aqueous solution. By constructing an analysis model with the system RGB value, the smartphone-assisted sensor-coated fluorescent test paper can complete the qualitative and quantitative visual detection of TC-PBQ (LOD is 93 nM). The applicability of smartphone-dependent RGB analysis significantly simplifies and speeds up the operation process, providing a new analytical method for real-time analysis of TC-PBQ in real samples.
MICROCHEMICAL JOURNAL
(2023)
Review
Medicine, Research & Experimental
Chunkang Liu, Kunzhe Wu, Jianyang Li, Xupeng Mu, Huan Gao, Xiaohua Xu
Summary: Patients with cholangiocarcinoma (CCA) have a poor prognosis due to its difficult early detection and treatment, low resectability rate, and poor response to anticancer drugs and radiotherapy. Despite advances in therapies, the five-year overall survival rate (OS) for CCA is only 5%. Nanoplatforms show promise in enhancing pharmacological effects and reducing side effects in cancer treatment, and this review discusses the advantages and shortcomings of various nanoparticles in the diagnosis and treatment of CCA, as well as the current challenges in nanoplatforms for CCA.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Nitis Smanthong, Ratree Tavichakorntrakool, Patcharaporn Tippayawat, Aroonlug Lulitanond, Porntip Pinlaor, Jureerut Daduang, Nattaya Sae-ung, Arunrat Chaveerach, Jutarop Phetcharaburanin, Patcharee Boonsiri
Summary: The ethanolic extract from Sida acuta leaves showed inhibitory effects on Proteus mirabilis and struvite crystal formation, suggesting potential for development as a new treatment for struvite stones induced by P. mirabilis. Phytochemical analysis identified bioactive compounds that contribute to these activities.
Article
Public, Environmental & Occupational Health
Manida Suksawat, Jutarop Phetcharaburanin, Poramate Klanrit, Nisana Namwat, Narong Khuntikeo, Attapon Titapun, Apiwat Jarearnrat, Vanlakhone Vilayhong, Prakasit Sa-ngiamwibool, Anchalee Techasen, Arporn Wangwiwatsin, Panupong Mahalapbutr, Jia V. Li, Watcharin Loilome
Summary: This study used metabolomics to analyze the metabolic characteristics in tissues and sera of CCA patients, and identified predictive biomarkers for gemcitabine and cisplatin sensitivity. These biomarkers can not only predict chemotherapy response, but also minimize the adverse effects of chemotherapy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Chemistry, Analytical
Sirirat Ouiganon, Chongdee Thammakhet-Buranachai, Panote Thavarungkul, Proespichaya Kanatharana, Chittanon Buranachai
Summary: This study developed a DNA-based fluorescent probe for sensitive detection of cysteine using a catalyzed hairpin assembly reaction. The probe exhibited good linearity, detection limit, and sensitivity, and showed potential for practical applications in detecting cysteine in food supplement samples.
METHODS AND APPLICATIONS IN FLUORESCENCE
(2022)
Article
Multidisciplinary Sciences
Chanika Worasith, Phattharaphon Wongphutorn, Chutima Homwong, Kulthida Y. Kopolrat, Anchalee Techasen, Raynoo Thanan, Chatanun Eamudomkarn, Chompunoot Wangboon, Narong Khuntikeo, Watcharin Loilome, Jiraporn Sithithaworn, Thomas Crellen, Paiboon Sithithaworn
Summary: Antigen detection in urine using ELISA is more sensitive than fecal examination for diagnosis and assessment of drug treatment in opisthorchiasis. There is a significant positive correlation between the concentration of antigen in urine and fecal egg counts. The urine assay has high diagnostic performance and minimal daily variation, making it useful for diagnosis and population screening of opisthorchiasis.
Article
Multidisciplinary Sciences
Sirinya Sitthirak, Manida Suksawat, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Sakkarn Sangkhamanon, Watcharin Loilome
Summary: This study investigated the association between the intratumoral microbiome and chemotherapeutic resistance in cholangiocarcinoma tissues using 16S rRNA sequencing and 1H NMR spectroscopic analysis. The results showed that specific bacteria and metabolites were significantly different between resistance and sensitive groups, suggesting their potential use as predictive markers for drug responses.
Article
Plant Sciences
Pattralak Songserm, Poramaporn Klanrit, Poramate Klanrit, Jutarop Phetcharaburanin, Pornthap Thanonkeo, Jirawan Apiraksakorn, Khamphee Phomphrai, Preekamol Klanrit
Summary: This study successfully established callus and cell suspension cultures of Rhinacanthus nasutus and found that the leaf and cell extracts have high antioxidant and anticancer activities. The identification of various compounds in the extracts provides valuable information for further development of phytochemical production using R. nasutus cell suspension culture.
Editorial Material
Nutrition & Dietetics
Kanokwan Nahok, Carlo Selmi, Manatsaphon Sukmak, Jutarop Phetcharaburanin, Jia V. Li, Atit Silsirivanit, Raynoo Thanan, Amod Sharma, Sirirat Anutrakulchai, Bruce D. Hammock, Ubon Cha'on
Article
Pharmacology & Pharmacy
Yingpinyapat Kittirat, Manida Suksawat, Suyanee Thongchot, Sureerat Padthaisong, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Sakkarn Sangkhamanon, Attapol Titapun, Watcharin Loilome, Hideyuki Saya, Nisana Namwat
Summary: Cancer-associated fibroblasts (CAFs) play a role in promoting gemcitabine resistance and enhancing cell viability in cholangiocarcinoma (CCA) cells through the activation of IL-6/STAT3 signaling. High expression of IL-6R is associated with poor overall survival rate and gemcitabine resistance in CCA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Nahathai Uttamamul, Manida Suksawat, Jutarop Phetcharaburanin, Supranee Jitpean, Aroonlug Lulitanond, Nattaya Sae-ung, Patcharee Boonsiri, Ratree Tavichakorntrakool
Summary: Staphylococcus pseudintermedius is a urease-producing bacteria that is a major cause of magnesium ammonium phosphate (MAP) urolithiasis in canine. Through metabolomics studies, we found that S. pseudintermedius undergoes metabolic changes after crystallization in artificial urine, which helps to explain the molecular mechanism behind the crystals induced by this bacteria strain.
Article
Multidisciplinary Sciences
Chatanun Eamudomkarn, Sirowan Ruantip, Jiraporn Sithithaworn, Anchalee Techasen, Kulthida Y. Kopoolrat, Chanika Worasith, Phattharaphon Wongphutorn, Jeffrey M. Bethony, Thewarach Laha, Paiboon Sithithaworn
Summary: Detection of anti-Strongyloides IgG in urine by ELISA showed comparable performance to conventional serum assays for diagnosing strongyloidiasis. Optimized urine ELISA protocols using different antigens yielded higher prevalence rates and showed potential as alternative diagnostic methods. The results supported the utility of urine specimens for the diagnosis of strongyloidiasis.
Article
Multidisciplinary Sciences
Pimpawadee Phukhum, Jutarop Phetcharaburanin, Kwuanjira Chaleekarn, Yingpinyapat Kittirat, Thanaporn Kulthawatsiri, Nisana Namwat, Watcharin Loilome, Narong Khuntikeo, Attapol Titapun, Arporn Wangwiwatsin, Tueanjit Khampitak, Manida Suksawat, Poramate Klanrit
Summary: The three-dimensional multicellular spheroid (3D MCS) model is used in cholangiocarcinoma research to mimic the physiological relevance and architecture of the tumor. The study found that poorly differentiated CCA cell lines were unable to form 3D MCS due to lack of cell adhesion molecules, while well-differentiated CCA and cholangiocyte cell lines were able to develop 3D MCSs with distinct phenotypic signatures. The 3D MCSs provide a different physiological state compared to 2D cultures, making it a valuable tool for studying drug sensitivity and alternate biochemical pathways.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Natcha Khuntikeo, Sureerat Padthaisong, Watcharin Loilome, Poramate Klanrit, Soontaree Ratchatapusit, Anchalee Techasen, Apiwat Jareanrat, Vasin Thanasukarn, Tharatip Srisuk, Vor Luvira, Jarin Chindaprasirt, Prakasit Sa-ngiamwibool, Chaiwat Aphivatanasiri, Piyapharom Intarawichian, Supinda Koonmee, Piya Prajumwongs, Attapol Titapun
Summary: This study found a high prevalence of dMMR in cholangiocarcinoma, and dMMR was identified as an independent prognostic factor for good survival, especially in early-stage CCA and for patients who received adjuvant chemotherapy.
Article
Food Science & Technology
Phuvadol Thanakiatkrai, Chittanon Buranachai, Thitika Kitpipit
Summary: Cow's milk and dairy products are common allergens. We developed a fast, accurate, and cost-effective assay to detect cow DNA in these products. The assay does not require sample preparation and can be completed quickly.
Article
Engineering, Electrical & Electronic
Kittirat Phooplub, Sirirat Ouiganon, Panote Thavarungkul, Proespichaya Kanatharana, Chittanon Buranachai
Summary: This work presents a portable device for measuring fluorescence and light absorption, using inexpensive and customizable light source and detectors. The results show good correlation with commercial instruments, making it beneficial for early or on-site detection.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
