Chromosome Missegregation as a Modulator of Radiation Sensitivity

Pan cancer patterns of allelic imbalance from chromosomal alterations in 33 tumor types

(2021) Smruthy Sivakumar et al.   GENETICS

Consequences of aneuploidy in human fibroblasts with trisomy 21

(2021) Sunyoung Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation in aneuploidy prevalence and tolerance across Saccharomyces cerevisiae lineages

(2021) Eduardo F C Scopel et al.   GENETICS

The fitness costs and benefits of trisomy of each Candida albicans chromosome

(2021) Feng Yang et al.   GENETICS

Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel

(2021) Christina M. Scribano et al.   Science Translational Medicine

TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination

(2020) Benjamin C. Chandler et al.   JOURNAL OF CLINICAL INVESTIGATION

Chromosome arm aneuploidies shape tumour evolution and drug response

(2020) Ankit Shukla et al.   Nature Communications

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity

(2020) Louisa Nelson et al.   Nature Communications

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Degree and site of chromosomal instability define its oncogenic potential

(2020) Wilma H. M. Hoevenaar et al.   Nature Communications

Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells

(2020) Nicolaas C Baudoin et al.   eLife

Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis

(2020) Roberta Sala et al.   MOLECULAR BIOLOGY OF THE CELL

p53 is not required for cell death and tumor suppression caused by high chromosomal instability

(2020) Laura C Funk et al.   MOLECULAR CANCER RESEARCH

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

(2019) Ana C. F. Bolhaqueiro et al.   NATURE GENETICS

Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas

(2019) Christopher D. Laucius et al.   CELL CYCLE

Banding Together: A Systematic Comparison of The Cancer Genome Atlas and the Mitelman Database

(2019) Connor Denomy et al.   CANCER RESEARCH

Improving breast cancer sensitivity to paclitaxel by increasing aneuploidy

(2019) Sylvie Rodrigues-Ferreira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division

(2018) Ana Rita R. Maia et al.   BRITISH JOURNAL OF CANCER

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

(2018) Begoña Cánovas et al.   CANCER CELL

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

(2018) Samra Turajlic et al.   CELL

Plk1 overexpression induces chromosomal instability and suppresses tumor development

(2018) Guillermo de Cárcer et al.   Nature Communications

Chromokinesins

(2018) Ana C. Almeida et al.   CURRENT BIOLOGY

Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence

(2017) Jian Yuan Goh et al.   NATURE MEDICINE

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

(2017) Floris Foijer et al.   eLife

Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression

(2016) Laura C. Funk et al.   DEVELOPMENTAL CELL

High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation

(2016) Lauren M. Zasadil et al.   MOLECULAR BIOLOGY OF THE CELL

Punctuated copy number evolution and clonal stasis in triple-negative breast cancer

(2016) Ruli Gao et al.   NATURE GENETICS

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells

(2016) K. M. Godek et al.   Cancer Discovery

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

(2016) Konstantina Rowald et al.   Cell Reports

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase

(2016) Judit Pampalona et al.   PLoS One

Selective advantage of trisomic human cells cultured in non-standard conditions

(2016) Samuel D. Rutledge et al.   Scientific Reports

Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial

(2015) M. Jamal-Hanjani et al.   ANNALS OF ONCOLOGY

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

(2015) A. R. R. Maia et al.   ANNALS OF ONCOLOGY

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

(2015) Noemi Andor et al.   NATURE MEDICINE

Numerical chromosomal instability mediates susceptibility to radiation treatment

(2015) Samuel F. Bakhoum et al.   Nature Communications

Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy

(2014) Bassem I. Zaki et al.   CANCER

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

(2014) Norman Ertych et al.   NATURE CELL BIOLOGY

Cyclin B2 and p53 control proper timing of centrosome separation

(2014) Hyun-Ja Nam et al.   NATURE CELL BIOLOGY

Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles

(2014) L. M. Zasadil et al.   Science Translational Medicine

DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation

(2014) S. F. Bakhoum et al.   Cancer Discovery

Identification of cell cycle–regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors

(2013) Gavin D. Grant et al.   MOLECULAR BIOLOGY OF THE CELL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

(2013) Emily C. Dykhuizen et al.   NATURE

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

(2013) A. D. Silk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells

(2013) Lauren M. Zasadil et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

(2012) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

(2012) S. D. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

(2012) Jin Zhu et al.   PLoS Genetics

Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer

(2011) R. Roylance et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

(2011) N. J. Birkbak et al.   CANCER RESEARCH

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Timing of centrosome separation is important for accurate chromosome segregation

(2011) William T. Silkworth et al.   MOLECULAR BIOLOGY OF THE CELL

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

(2010) Liviu Malureanu et al.   JOURNAL OF CELL BIOLOGY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic Catastrophe

(2009) F. Ianzini et al.   CANCER RESEARCH

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

(2009) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice

(2009) Min Li et al.   JOURNAL OF CELL BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics

The Aneuploidy Paradox in Cell Growth and Tumorigenesis

(2008) Beth A. Weaver et al.   CANCER CELL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Whole chromosome instability and cancer: a complex relationship

(2008) Robin M. Ricke et al.   TRENDS IN GENETICS