Review
Microbiology
Emily M. Wollmuth, Esther R. Angert
Summary: Circadian rhythms have important impacts on gene expression and metabolism in bacteria, but so far, only the circadian clock mechanism in cyanobacteria has been revealed. Daily oscillations in microbial communities are largely controlled by light-dark cycles in marine ecosystems and symbioses, while the influx of nutrients in the gut system can significantly alter the gut microbiota. Further research is needed to confirm whether heterotrophic bacteria associated with hosts possess circadian rhythm systems and how they respond to diel cycles.
Review
Microbiology
Graham J. Britton, Jeremiah J. Faith
Summary: Identifying causative microbes in the human microbiome is challenging due to its complexity, but advances in sequencing technology, animal models, and bacterial culturing have started to reveal specific microbes impacting the host. Understanding the effects of commensals on the immune system, inflammation, and metabolism is crucial for fully comprehending disease processes and potential therapeutic benefits. Challenges in identifying causative commensal microbes are still present, but potential remedies are being suggested to address common pitfalls in this field.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Review
Multidisciplinary Sciences
Pierre-Marc Delaux, Sebastian Schornack
Summary: Over 450 million years of evolution on land, plants and microbes have formed diverse relationships, from parasitism to mutualism. Scientists have started to unravel the genetic basis and evolutionary trajectories of plant-microbe associations through phylogenetics, cell biology, and reverse genetics. The co-option of protection mechanisms and general cell biology principles is proposed as the basis for symbiosis.
Article
Nutrition & Dietetics
Yu Tahara, Saneyuki Makino, Takahiko Suiko, Yuki Nagamori, Takao Iwai, Megumi Aono, Shigenobu Shibata
Summary: Irregular meal timing is associated with higher neuroticism, sleep problems, and lower subjective health conditions, indicating its significant impact on mental health and overall well-being.
Article
Microbiology
Jessica Dittmer, Robert M. Brucker
Summary: This study investigated the role of microbiome in host nutrient allocation during diapause of parasitoid wasp N. vitripennis, revealing the essential role of microbiome and altered microbiome composition during diapause. The prolonged larval diapause had a transstadial effect on the adult microbiome, leading to changes in the abundance of dominant microbiome members and potential bacterial pathogens. The impact of diapause on the microbiome is likely influenced by various factors, including altered host regulatory mechanisms and the host environment.
Review
Biochemistry & Molecular Biology
Sara M. Ortega-Campos, Eva M. Verdugo-Sivianes, Ana Amiama-Roig, Jose R. Blanco, Amancio Carnero
Summary: The molecular machinery of the circadian clock regulates gene expression and cellular activities to adapt to daily light-dark cycles. Disruption of the circadian rhythm is an independent risk factor for cancer and circadian genes may play dual roles as tumor suppressors and oncogenes. Understanding the molecular basis of the circadian clock can help identify new markers and targets for cancer prognosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Microbiology
Phillipe M. Rosado, Pedro M. Cardoso, Joao G. Rosado, Junia Schultz, Ulisses Nunes da Rocha, Tina Keller-Costa, Raquel S. Peixoto
Summary: The study shows that beneficial microorganisms can effectively alleviate bleaching and mitigate coral mortality. A comprehensive genetic survey is conducted to identify alternative mechanisms for selecting beneficial microorganism strains. New mechanisms such as glycine betaine and ectoine synthesis are proposed. This research provides insights for the selection and application of beneficial microorganisms as coral probiotics.
Review
Oncology
Lasse D. Jensen, Delmy Oliva, Bengt-Ake Andersson, Freddi Lewin
Summary: Sleep is often neglected in modern societies, leading to circadian disruption in cancer patients which negatively impacts treatment outcomes, survival, and quality of life. The lack of integrated approaches due to fragmented understanding across disciplines hinders effective management of this issue in cancer patients.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Plant Sciences
Xingwei Wang, Yanfei Hu, Wei Wang
Summary: This study compares the circadian characteristics of Arabidopsis and soybean, revealing notable differences and contrasting biological activities under circadian regulation.
Editorial Material
Microbiology
Patrick H. Bradley
Summary: In this study, Zeng et al. demonstrate that a specific gut microbe is responsible for reducing acetaminophen toxicity in mice depending on their diet. The connection between gut microbes and toxicity is shown to be mechanistically detailed, but interestingly indirect, involving the transformation of ingested phytochemicals rather than the drug itself.
CELL HOST & MICROBE
(2023)
Article
Biology
Patricia Jarabo, Celia G. Barredo, Carmen de Pablo, Sergio Casas-Tinto, Francisco A. Martin
Summary: Neurodegeneration induced by glioblastoma disrupts circadian rhythms in Drosophila, and aligning these rhythms with the external period can lead to a longer lifespan, suggesting a potential therapeutic approach for human glioblastoma.
COMMUNICATIONS BIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Michael J. Rust
Summary: The study on circadian clock suggests that it can function even in non-growing cells using minimal components from cyanobacteria. The findings indicate the potential evolution of the circadian clock to adapt to different cellular conditions.
Article
Biochemistry & Molecular Biology
Tomoki Sato, Carolina Magdalen Greco
Summary: Circadian rhythms play a central role in regulating physiological and metabolic processes by dynamically influencing gene expression through epigenetic changes. Evidence suggests that oxidative stress and redox balance are controlled by circadian rhythms and in turn affect the clock system. Disruption of circadian rhythms leads to oxidative stress accumulation and disturbances in redox balance, along with significant changes in the epigenomic landscape.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Sourbh Rankawat, Kavita Kundal, Shreyayukta Chakraborty, Rahul Kumar, Sandipan Ray
Summary: Research has shown that the transcript level of blood proteins associated with immune responses and susceptibility to malaria exhibit rhythmic patterns. These rhythmic proteins are involved in multiple physiological pathways related to host immune and defense responses. The findings demonstrate the circadian regulation of host immune pathways and immunological networks in malaria.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Supreet Khanal, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta
Summary: This study provides evidence for the first time that Anaplasma phagocytophilum modulates the arthropod circadian gene for its transmission to the vertebrate host. The results suggest that the circadian modulation of tick gene expression plays an important role in arthropod blood feeding and transmission of pathogens from vector to the vertebrate host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
