Article
Cardiac & Cardiovascular Systems
Rongrong Gao, Lijun Wang, Yihua Bei, Xiaodong Wu, Jiaqi Wang, Qiulian Zhou, Lichan Tao, Saumya Das, Xinli Li, Junjie Xiao
Summary: Through lncRNA microarray profiling, we identified a novel long noncoding RNA (lncRNA) associated with exercise-induced cardiac growth, named cardiac physiological hypertrophy-associated regulator (CPhar). Our study reveals the cardioprotective role of CPhar in the heart and expands our understanding of lncRNA function.
Article
Veterinary Sciences
Ning Zhang, Gaoxiao Xu, Ping Sun, Shuzhe Wang, Yunchang Zhu, Saixing Duan, Mingsheng Jiang, Hui Li, Xuefeng Wei, Yun Ma
Summary: The study utilized the Ribo-Zero RNA-Seq method to identify specific lncRNA expression profiles in buffalo myoblasts during proliferation and differentiation. It revealed a large number of differentially expressed lncRNAs, including Gene11007 which was found to promote the proliferation of buffalo myoblasts during differentiation.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fang Wei, Yong Wang, Yong Zhou, Yan Li
Summary: Research has shown that increased expression of CYTOR is associated with metastatic gastric cancer and correlates with the malignancy of the disease. Knockdown of CYTOR inhibits cell proliferation and migration, while inducing cell apoptosis. CYTOR acts as a sponge for miR-103, reducing miR-103 expression and leading to increased oncogene RAB10 expression.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemical Research Methods
Jianjun Jiang, Lehua Cheng, Liang Yan, Mingxia Ge, Liqin Yang, Haoqiang Ying, Qingpeng Kong
Summary: The study identified specific lncRNAs in centenarians related to longevity as well as their regulatory roles in cellular aging processes. These dysregulated lncRNAs in centenarians may serve as potential protective factors in healthy aging.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Cardiac & Cardiovascular Systems
Hairuo Lin, Yingqi Zhu, Cankun Zheng, Donghong Hu, Siyuan Ma, Lin Chen, Qiancheng Wang, Zhenhuan Chen, Jiahe Xie, Yi Yan, Xiaobo Huang, Wangjun Liao, Masafumi Kitakaze, Jianping Bin, Yulin Liao
Summary: Exercise-induced myocardial hypertrophy preconditioning can increase myocardial resistance to pathological stress through an antihypertrophic effect mediated by the Mhrt779/Brg1/Hdac2/p-Akt/p-GSK3 beta signaling pathway.
Article
Gastroenterology & Hepatology
Guang-Lin Lei, Yan Niu, Si-Jie Cheng, Yuan-Yuan Li, Zhi-Fang Bai, Ling-Xiang Yu, Zhi-Xian Hong, Hu Liu, Hong-Hong Liu, Jin Yan, Yuan Gao, Shao-Geng Zhang, Zhu Chen, Rui-Sheng Li, Peng-Hui Yang
Summary: This study identified a novel lncRNA (lncRNA W42) and investigated its biological functions and clinical significance in HCC. Results demonstrated that lncRNA W42 was upregulated in HCC tissues and cells, promoting proliferative and invasive abilities while inhibiting apoptosis. Additionally, HCC patients with high lncRNA W42 expression showed shorter survival times.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Toshihiko Takeiwa, Yuichi Mitobe, Kazuhiro Ikeda, Kosei Hasegawa, Kuniko Horie, Satoshi Inoue
Summary: Recent studies have identified an overexpressed lincRNA, termed OIN1, in ovarian cancer tissues which, when silenced by specific siRNA, significantly inhibits proliferation and enhances apoptosis in ovarian cancer cells. RNA sequencing revealed a negative correlation between OIN1 expression and apoptosis-related genes RASSF5 and ADORA1, which were upregulated by OIN1 knockdown. OIN1-specific siRNA injection effectively suppressed in vivo tumor growth of ovarian cancer cells in immunodeficient mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Joshua K. Stone, Lana Vukadin, Eun-Young Erin Ahn
Summary: The novel eRNA eNEMAL transcribed from the MALAT1-20 kb enhancer regulates NEAT1 isoform expression in breast cancer cells, suggesting a co-regulation of MALAT1 and NEAT1 in response to hypoxia.
Article
Biochemistry & Molecular Biology
Shuai Yang, Hui Li, Haipei Yao, Yao Zhang, Huiqian Bao, Liangjing Wu, Conghui Zhang, Min Li, Le Feng, Jingfa Zhang, Zhi Zheng, Guotong Xu, Fang Wang
Summary: The study revealed that lncRNA ERLR plays a role in TGF-beta 1-induced EMT in human RPE cells and is involved in the pathogenesis of PVR, providing new insights into the mechanism and treatment of the disease.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Medicine, Research & Experimental
Jianming Lu, Chuanfan Zhong, Junqi Luo, Fangpeng Shu, Daojun Lv, Zezhen Liu, Xiao Tan, Shuo Wang, Kaihui Wu, Taowei Yang, Weibo Zhong, Bin Wang, Yanfei Chen, Yuehan Li, Zhenyu Jia, Yaguang Zou, Weide Zhong, Xiangming Mao
Summary: This study demonstrated the biological relevance of circCSPP1 and HnRNP-L in the progression of prostate cancer, indicating that increased circCSPP1 in prostate cancer cells regulated by HnRNP-L can induce autophagy, leading to enhanced proliferation, migration, and invasion. Furthermore, a potential competing endogenous RNA network involving circCSPP1, miR-520h, and EGR1 was revealed in prostate cancer cells, suggesting its significance in prostate cancer progression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Mengjie Chen, Qingyou Liu, Mingming Song, Xingyu Liu, Kongwei Huang, Dandan Zhong, Yaling Chen, Mingsheng Jiang, Junming Sun, Yiqiang Ouyang, Suren R. Sooranna, Deshun Shi, Hui Li
Summary: This study analysed circRNA expression profiles during the proliferation and differentiation stages of buffalo myoblasts using RNA-seq. A novel noncoding regulator, circCLTH, was identified to promote proliferation and differentiation of myoblasts and skeletal muscles.
Article
Cell Biology
Wei Xu, Linna Chen, Jiheng Liu, Zhezhe Zhang, Ranran Wang, Qianqian Zhang, Huiting Li, Juanjuan Xiang, Li Fang, Ping Xu, Zheng Li
Summary: This study reveals that TGF-beta-induced LINC00152 promotes metastasis in lung adenocarcinoma through the involvement of HuR and the regulation of transcription factors ZEB1, SNAI1, and SNAI2, which ultimately leads to epithelial-mesenchymal transition and enhanced metastatic ability.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
Aipeng Li, Jingpu Yang, Ting Zhang, Lin Li, Miyang Li
Summary: The study reveals that TRPM2-AS is upregulated in RB, associated with advanced clinical stage and optic nerve invasion. Downregulation of TRPM2-AS significantly inhibits proliferation, migration, and invasion of RB cells, promotes apoptosis, and attenuates G2/M phase arrest.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Xing-Cheng Wu, Wei-Gang Yan, Zhi-Gang Ji, Guo-Yang Zheng, Guang-Hua Liu
Summary: This study revealed that SNHG20 promotes PCa cell proliferation and migration by acting as a ceRNA to upregulate DDX17, which is highly expressed and oncogenic in PCa. The findings suggest that SNHG20 may be a potential novel therapeutic target for PCa.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Tao Cai, Binyu Peng, Jun Hu, Yan He
Summary: Gastric cancer is a significant health burden worldwide, but the molecular mechanisms underlying its progression are not well understood. This study reveals the role of BBOX1-AS1 in regulating gastric cancer progression through the miR-361-3p/MUC13 axis, providing a potential therapeutic target for the treatment of gastric cancer.
Article
Psychology, Developmental
Anna Lahdepuro, Marius Lahti-Pulkkinen, Riikka Pyhala, Soile Tuovinen, Jari Lahti, Kati Heinonen, Hannele Laivuori, Pia M. Villa, Rebecca M. Reynolds, Eero Kajantie, Polina Girchenko, Katri Raikkonen
Summary: The study found that positive maternal mental health during pregnancy is associated with a reduced risk of mental and behavioral disorders in children. This association is also seen in children of mothers facing mental health issues.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Cell Biology
Terytty Yang Li, Arwen W. Gao, Xiaoxu Li, Hao Li, Yasmine J. Liu, Amelia Lalou, Nagammal Neelagandan, Felix Naef, Kristina Schoonjans, Johan Auwerx
Summary: Stressed mitochondria activate the mitochondrial unfolded protein response (UPRmt) to improve organismal health. A study found that increased ATFS-1 translation, mediated by v-ATPase/TORC1, plays an essential role in UPRmt activation and mild mitochondrial stress-induced longevity.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jolien Rijlaarsdam, Marta Cosin, Laura Schellhas, Sarina Abrishamcar, Anni Malmberg, Alexander Neumann, Janine F. Felix, Jordi Sunyer, Kristine B. Gutzkow, Regina Grazuleviciene, John Wright, Mariza Kampouri, Heather J. Zar, Dan J. Stein, Kati Heinonen, Katri Raikkonen, Jari Lahti, Anke Huels, Doretta Caramaschi, Silvia Alemany, Charlotte A. M. Cecil
Summary: The general psychopathology factor (GPF) has been proposed as a way to capture variance shared between psychiatric symptoms. In this study, epigenome-wide meta-analyses were conducted to identify associations of DNA methylation (DNAm) with school-age general psychopathology, revealing evidence of an association between DNAm at school-age and GPF.
MOLECULAR PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Mette K. Andersen, Lars Angquist, Jette Bork-Jensen, Anna E. Jonsson, Sara E. Stinson, Camilla H. Sandholt, Malte Thodberg, Laura Maarit Pikkupeura, Emily L. Ongstad, Niels Grarup, Arne Astrup, Oluf Pedersen, Kristine Williams, Romain Barres, Thorkild I. A. Sorensen, Allan Linneberg, Joseph Grimsby, Christopher J. Rhodes, Torben Hansen
Summary: The association between FTO rs9939609 and obesity is modified by physical activity and insulin sensitivity, and these modifications are independent. High physical activity and insulin sensitivity can attenuate the effect of the FTO rs9939609 A allele on BMI. Moreover, greater physical activity and insulin sensitivity may weaken the associations between the FTO rs9939609 A allele and all-cause mortality and certain cardiometabolic outcomes. The FTO rs9939609 A allele is associated with higher expression of FTO in skeletal muscle.
Article
Immunology
Giorgia Benegiamo, Giacomo V. G. von Alvensleben, Sandra Rodriguez-Lopez, Ludger J. E. Goeminne, Alexis M. Bachmann, Jean-David Morel, Ellen Broeckx, Jing Ying Ma, Vinicius Carreira, Sameh A. Youssef, Nabil Azhar, Dermot F. Reilly, Katharine D'Aquino, Shannon Mullican, Maroun Bou-Sleiman, Johan Auwerx
Summary: Mice from different genetic backgrounds have diverse responses to metabolic challenges. PWK/PhJ mice show significant mitochondrial dysfunction and progress to fibrotic NASH similar to human NASH, making them a novel NASH mouse model.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Mikkel Hoeberg, Julie Boertmann Noer, Mette Vixo Vistesen, Annette Bartels, Esben Matzen Bech, Sune Boris Nygard, Ulrik Lademann, Jan Stenvang, Siqi Liu, Anja Thoe Fuglsang, Nils Bruenner, Jose Manuel Afonso Moreira
Summary: Tissue inhibitor of metalloproteinases-1 (TIMP-1) plays a crucial role in regulating proteolytic activity and maintaining the extracellular matrix. This protein has been associated with multiple MMP-independent cytokine-like functions. Through a yeast two-hybrid screening, multiple interaction partners, including CD74, were identified, shedding light on the complex nature of TIMP-1 functions and their mechanisms.
MOLECULAR ONCOLOGY
(2023)
Article
Cell Biology
Tanes I. Lima, Pirkka-Pekka Laurila, Martin Wohlwend, Jean David Morel, Ludger J. E. Goeminne, Hao Li, Mario Romani, Xiaoxu Li, Chang-Myung Oh, Dohyun Park, Sandra Rodriguez-Lopez, Julijana Ivanisevic, Hector Gallart-Ayala, Barbara Crisol, Florence Delort, Sabrina Batonnet-Pichon, Leonardo R. Silveira, Lakshmi Sankabattula Pavani Veera Venkata, Anil K. Padala, Suresh Jain, Johan Auwerx
Summary: Disruption of ceramide biosynthesis leads to the decline in mitochondrial and protein homeostasis during muscle aging. Through transcriptome analysis of muscle biopsies, it was found that disturbance in ceramide biosynthesis, mitochondrial function, and protein homeostasis are prevalent features in aged individuals and patients with muscle disorders. Inhibition of ceramide biosynthesis restores proteostasis and mitochondrial function, improving muscle health and lifespan in both nematodes and mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Genetics & Heredity
Karri Kaivola, Matti Pirinen, Hannu Laaksovirta, Lilja Jansson, Osma Rautila, Jyrki Launes, Laura Hokkanen, Jari Lahti, Johan G. Eriksson, Timo E. Strandberg, FinnGen, Pentti J. Tienari
Summary: C9orf72 hexanucleotide repeat expansion is a common cause of ALS and FTD. The study found the best tagging single nucleotide polymorphisms for the hexanucleotide repeat expansion and intermediate-length alleles, and demonstrated a potential residual risk at the C9orf72 locus.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Lewin Small, Leonidas S. Lundell, Jo Iversen, Amy M. Ehrlich, Morten Dall, Astrid L. Basse, Emilie Dalbram, Ann N. Hansen, Jonas T. Treebak, Romain Barres, Juleen R. Zierath
Summary: Seasonal light affects energy metabolism by modulating the rhythmicity of food intake, rather than melatonin.
Article
Gastroenterology & Hepatology
Jacob Mathias Bech, Thilde Terkelsen, Annette Snejbjerg Bartels, Fabian Coscia, Sophia Doll, Siqi Zhao, Zhaojun Zhang, Nils Brunner, Jan Lindebjerg, Gunvor Iben Madsen, Xiangdong Fang, Matthias Mann, Jose Manuel Afonso Moreira
Summary: By analyzing the proteomic data of resected adenoma samples, researchers found that the proteome can predict the future occurrence of advanced lesions and progression to colorectal cancer several years in advance.
Article
Cell Biology
Adriana Ibarra Urizar, Michala Prause, Lars Roed Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barres, Martin R. Larsen, Gitte Lund Christensen, Nils Billestrup
Summary: Insufficient insulin secretion in type 2 diabetes is caused by decreased expression of key beta cell genes. BMP-2, an inflammatory factor, inhibits beta cell function and proliferation. This study investigated how BMP-2 induces beta cell dysfunction and loss of cell maturity.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Simon Ebert, Lan Zang, Noor Ismail, Michael Otabil, Adrian Frohlich, Virginia Egea, Susann Acs, Mikkel Hoeberg, Marie-Luise Berres, Christian Weber, Jose M. A. Moreira, Christian Ries, Juergen Bernhagen, Omar El Bounkari
Summary: TIMP-1 interacts with CD74 to regulate vascular inflammation and atherosclerosis. TIMP-1 binding to CD74 promotes monocyte migration and vascular smooth muscle cell proliferation, playing a crucial role in vascular inflammation and atherosclerosis.
Article
Cell Biology
Terytty Yang Li, Qi Wang, Arwen W. Gao, Xiaoxu Li, Yu Sun, Adrienne Mottis, Minho Shong, Johan Auwerx
Summary: Lysosomal acidification through v-ATPase is crucial for the transcriptional activation of the mitochondrial unfolded protein response (UPRmt). The activation of lysosomes by v-ATPase stimulates mTORC1, which then phosphorylates the transcription factor ATF4, leading to the activation of the UPRmt and mitochondrial function resilience.
Article
Psychology, Developmental
Anna Lahdepuro, Marius Lahti-Pulkkinen, Polina Girchenko, Pia M. Villa, Kati Heinonen, Jari Lahti, Riikka Pyhala, Hannele Laivuori, Eero Kajantie, Katri Raikkonen
Summary: Positive maternal mental health during pregnancy has a positive impact on children's psychiatric problems. This study found that higher positive maternal mental health scores during pregnancy were associated with lower total psychiatric problem scores in both early and late childhood.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2023)