Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids

One-Stop Microfluidic Assembly of Human Brain Organoids To Model Prenatal Cannabis Exposure

(2020) Zheng Ao et al.   ANALYTICAL CHEMISTRY

Assessing Toxicity with Human Cell-Based In Vitro Methods

(2020) Daniele Zink et al.   TRENDS IN MOLECULAR MEDICINE

Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5/AMPK-JNK signaling pathway

(2020) Xiaoling Chen et al.   NEUROPHARMACOLOGY

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

(2020) Yingchao Shi et al.   PLOS BIOLOGY

Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids

(2020) Qian Bu et al.   FOOD AND CHEMICAL TOXICOLOGY

Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1

(2020) Attalla Farag El-kott et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Protocatechuic acid mitigates cadmium-induced neurotoxicity in rats: Role of oxidative stress, inflammation and apoptosis

(2020) Ebtesam M. Al Olayan et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Multi-walled carbon nanotubes decrease neuronal NO synthase in 3D brain organoids

(2020) Ying Jiang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

(2020) Fadi Jacob et al.   Cell Stem Cell

SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids

(2020) Laura Pellegrini et al.   Cell Stem Cell

Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis

(2020) Rili Hao et al.   FOOD AND CHEMICAL TOXICOLOGY

The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway

(2020) Dhondup Namgyal et al.   TOXICOLOGY

Cadmium induces actin cytoskeleton alterations and dysfunction in Neuro-2a cells

(2019) Yaming Ge et al.   ENVIRONMENTAL TOXICOLOGY

Induced pluripotent stem cells in disease modelling and drug discovery

(2019) R. Grant Rowe et al.   NATURE REVIEWS GENETICS

Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns

(2019) Lina Zhang et al.   BMC Medicine

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Human 3D cellular model of hypoxic brain injury of prematurity

(2019) Anca M. Pașca et al.   NATURE MEDICINE

Maternal exposure to cadmium impairs cognitive development of male offspring by targeting the Coronin-1a signaling pathway

(2019) Jianfeng Feng et al.   CHEMOSPHERE

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Association of Acute, High-dose Cadmium Exposure with Alterations in Vascular Endothelial Barrier Antigen Expression and Astrocyte Morphology in the Developing Rat Central Nervous System

(2019) M.O. Ibiwoye et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Neuronal specific and non-specific responses to cadmium possibly involved in neurodegeneration: A toxicogenomics study in a human neuronal cell model

(2019) M. Forcella et al.   NEUROTOXICOLOGY

Transcriptomic insight into cadmium-induced neurotoxicity in embryonic neural stem/progenitor cells

(2019) Ping Deng et al.   TOXICOLOGY IN VITRO

Primary Cilia in Brain Development and Diseases

(2018) Yong Ha Youn et al.   AMERICAN JOURNAL OF PATHOLOGY

Association between dietary patterns, cadmium intake and chronic kidney disease among adults

(2018) Zumin Shi et al.   CLINICAL NUTRITION

Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts

(2018) Todd M. Everson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway

(2018) Yan Yuan et al.   Scientific Reports

An ecotoxicological view on neurotoxicity assessment

(2018) J. B. Legradi et al.   Environmental Sciences Europe

Disease-related responses induced by cadmium in an in vitro human airway tissue model

(2018) Rui Xiong et al.   TOXICOLOGY LETTERS

Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders

(2017) Beihui Liu et al.   GLIA

Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB pathways

(2017) Suttinee Phuagkhaopong et al.   NEUROTOXICOLOGY

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size

(2016) Tomoki Otani et al.   Cell Stem Cell

Dietary acrylamide intake during pregnancy and anthropometry at birth in the French EDEN mother-child cohort study

(2016) M. Kadawathagedara et al.   ENVIRONMENTAL RESEARCH

Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine

(2016) Maria Kippler et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Motile and non-motile cilia in human pathology: from function to phenotypes

(2016) Hannah M Mitchison et al.   JOURNAL OF PATHOLOGY

CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit

(2016) Chun-Ting Lee et al.   NEUROPSYCHOPHARMACOLOGY

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review

(2015) Katarzyna Byber et al.   CRITICAL REVIEWS IN TOXICOLOGY

Effects of subcytotoxic cadmium on morphology of glial fibrillary acidic protein network in astrocytes derived from murine neural stem/progenitor cells

(2015) Hideki Mori et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Environmental factors in cardiovascular disease

(2015) Kristen E. Cosselman et al.   Nature Reviews Cardiology

Differential sensitivity of immature and mature ventral mesencephalic neurons to rotenone induced neurotoxicity in vitro

(2015) V. Satish Bollimpelli et al.   TOXICOLOGY IN VITRO

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Primary Cilia in the Developing and Mature Brain

(2014) Alicia Guemez-Gamboa et al.   NEURON

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Maternal Cadmium Levels during Pregnancy Associated with Lower Birth Weight in Infants in a North Carolina Cohort

(2014) Jill E. Johnston et al.   PLoS One

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Cadmium and Its Neurotoxic Effects

(2013) Bo Wang et al.   Oxidative Medicine and Cellular Longevity

Cadmium induces alterations in the human spinal cord morphogenesis

(2011) Erica Sarchielli et al.   BIOMETALS

Interleukin-6, a mental cytokine

(2011) Anneleen Spooren et al.   BRAIN RESEARCH REVIEWS

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Effects of Gestational Cadmium Exposure on Pregnancy Outcome and Development in the Offspring at Age 4.5 Years

(2009) Li-Li Tian et al.   BIOLOGICAL TRACE ELEMENT RESEARCH