Diversification of aliphatic C–H bonds in small molecules and polyolefins through radical chain transfer

Closed-loop recycling of polyethylene-like materials

(2021) Manuel Häußler et al.   NATURE

Toward polymer upcycling—adding value and tackling circularity

(2021) LaShanda T. J. Korley et al.   SCIENCE

Cerium-Catalyzed C–H Functionalizations of Alkanes Utilizing Alcohols as Hydrogen Atom Transfer Agents

(2020) Qing An et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Late-stage oxidative C(sp3)–H methylation

(2020) Kaibo Feng et al.   NATURE

Diverse functionalization of strong alkyl C–H bonds by undirected borylation

(2020) Raphael Oeschger et al.   SCIENCE

Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from Trypanosoma cruzi

(2020) Fabrício Fredo Naciuk et al.   ACS Medicinal Chemistry Letters

Late-Stage Diversification of Natural Products

(2020) Benke Hong et al.   ACS Central Science

Finding Opportunities from Surprises and Failures. Development of Rhodium-Stabilized Donor/Acceptor Carbenes and their Application to Catalyst-Controlled C—H Functionalization.

(2019) Huw M. L. Davies   JOURNAL OF ORGANIC CHEMISTRY

Identifying Amidyl Radicals for Intermolecular C–H Functionalizations

(2019) Matthew M. Tierney et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemo- and Regioselective Functionalization of Isotactic Polypropylene: A Mechanistic and Structure–Property Study

(2019) Jill B. Williamson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A broadly applicable cross-linker for aliphatic polymers containing C–H bonds

(2019) Mathieu L. Lepage et al.   SCIENCE

Late-stage trifluoromethylthiolation of benzylic C-H bonds

(2019) Wentao Xu et al.   Nature Communications

Regioselective C−H Xanthylation as a Platform for Polyolefin Functionalization

(2018) Jill B. Williamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Strategy for Aliphatic C–H Functionalization Enabled by Organic Photoredox Catalysis

(2018) Kaila A. Margrey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deoxyfluorination with Sulfonyl Fluorides: Navigating Reaction Space with Machine Learning

(2018) Matthew K. Nielsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

Mild halogenation of polyolefins using an N-haloamide reagent

(2018) Christopher M. Plummer et al.   Polymer Chemistry

Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds

(2018) Rohan R. Merchant et al.   SCIENCE

Aliphatic C—H Oxidations for Late-Stage Functionalization

(2018) M. Christina White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct arylation of strong aliphatic C–H bonds

(2018) Ian B. Perry et al.   NATURE

Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds

(2018) Kuangbiao Liao et al.   Nature Chemistry

Current advances of carbene-mediated photoaffinity labeling in medicinal chemistry

(2018) Sha-Sha Ge et al.   RSC Advances

C-H Functionalization of Commodity Polymers

(2018) Jill B. Williamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-Free Radical Borylation of Alkyl and Aryl Iodides

(2018) Ying Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Generation of Anhydrous Hydrogen Iodide: An Effective Method for the Preparation of Iodoalkanes

(2018) Chaoyuan Zeng et al.   ORGANIC LETTERS

A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides

(2018) Daniel Meyer et al.   Nature Communications

Aliphatic C–H Bond Iodination by a N-Iodoamide and Isolation of an Elusive N-Amidyl Radical

(2017) Alexander Artaryan et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Alkylation of Aliphatic Amines Induced by Visible Light

(2017) Carson D. Matier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-mediated cross-coupling of C-17 lithiated androst-16-en-3-ol – access to functionalized arylated steroid derivatives

(2017) Vanessa Koch et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Radical C–H Fluorination Using Unprotected Amino Acids as Radical Precursors

(2017) Alyssa M. Hua et al.   ORGANIC LETTERS

Dual gold and photoredox catalysis: visible light-mediated intermolecular atom transfer thiosulfonylation of alkenes

(2017) Haoyu Li et al.   Chemical Science

Site-Selective C–H Functionalization by Decatungstate Anion Photocatalysis: Synergistic Control by Polar and Steric Effects Expands the Reaction Scope

(2017) Davide Ravelli et al.   ACS Catalysis

Chemical recycling of waste plastics for new materials production

(2017) AliReza Rahimi et al.   Nature Reviews Chemistry

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Let's Be Clear(er) about Substitution: A Reporting Framework to Account for Product Displacement in Life Cycle Assessment

(2016) Carl Vadenbo et al.   JOURNAL OF INDUSTRIAL ECOLOGY

Site-Selective Aliphatic C–H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide

(2016) Ryan K. Quinn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H Xanthylation: A Synthetic Platform for Alkane Functionalization

(2016) William L. Czaplyski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct azidation of isotactic polypropylene and synthesis of ‘grafted to’ derivatives thereof using azide-alkyne cycloaddition chemistry

(2016) Di Liu et al.   POLYMER INTERNATIONAL

Fundamental Difference in Reductive Lithiations with Preformed Radical Anions versus Catalytic Aromatic Electron-Transfer Agents: N ,N- Dimethylaniline as an Advantageous Catalyst

(2015) Nicole Kennedy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Trifluoromethylthiolation of Unactivated C(sp3)H Using Silver(I) Trifluoromethanethiolate and Potassium Persulfate

(2015) Hao Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Manganese-Catalyzed Late-Stage Aliphatic C–H Azidation

(2015) Xiongyi Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of C–H Bond Functionalization from Methane to Methodology

(2015) John F. Hartwig   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Convergent Radical Based Route to Trifluoromethyl Ketones and to α,β-Unsaturated Trifluoromethyl Ketones

(2015) Lucile Anthore et al.   ORGANIC LETTERS

A Convenient Photocatalytic Fluorination of Unactivated CH Bonds

(2014) Shira D. Halperin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct, Catalytic Monofluorination of sp3 C–H Bonds: A Radical-Based Mechanism with Ionic Selectivity

(2014) Cody Ross Pitts et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Selective Aliphatic C–H Bromination Using N-Bromoamides and Visible Light

(2014) Valerie A. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh(III)-Catalyzed Cyclopropanation Initiated by C–H Activation: Ligand Development Enables a Diastereoselective [2 + 1] Annulation of N-Enoxyphthalimides and Alkenes

(2014) Tiffany Piou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conserved Class of Queen Pheromones Stops Social Insect Workers from Reproducing

(2014) A. Van Oystaeyen et al.   SCIENCE

Epiandrosterone-derived prolinamide as an efficient asymmetric catalyst for Michael addition reactions of aldehydes to nitroalkenes

(2014) Yongchao Wang et al.   RSC Advances

Efficient Dye-Sensitized Solar Cells with Potential-Tunable Organic Sulfide Mediators and Graphene-Modified Carbon Counter Electrodes

(2013) Xiong Li et al.   ADVANCED FUNCTIONAL MATERIALS

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid, Stable, Chemoselective Labeling of Thiols with Julia-Kocieński-like Reagents: A Serum-Stable Alternative to Maleimide-Based Protein Conjugation

(2013) Narihiro Toda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An easy access to fluoroalkanes by deoxygenative hydrofluorination of carbonyl compounds via their tosylhydrazones

(2013) Arvind K. Yadav et al.   CHEMICAL COMMUNICATIONS

Oxidative Aliphatic C-H Fluorination with Fluoride Ion Catalyzed by a Manganese Porphyrin

(2012) W. Liu et al.   SCIENCE

Adding Aliphatic C-H Bond Oxidations to Synthesis

(2012) M. C. White   SCIENCE

Facile conversion of racemic ibuprofen to (S)-ibuprofen

(2012) David Chavez-Flores et al.   TETRAHEDRON-ASYMMETRY

Photochemically Induced Radical Transformation of C(sp3)–H Bonds to C(sp3)–CN Bonds

(2011) Shin Kamijo et al.   ORGANIC LETTERS

Total Synthesis of (+)-Bourgeanic Acid Utilizingo-DPPB-Directed Allylic Substitution

(2009) Tomislav Reiss et al.   ORGANIC LETTERS

Elemental fluorine

(2008) Richard D. Chambers et al.   JOURNAL OF FLUORINE CHEMISTRY

Review and critical analysis of the morphology of random ionomers across many length scales

(2008) Brian P. Grady   POLYMER ENGINEERING AND SCIENCE