Article
Chemistry, Multidisciplinary
Min-Hyeok Kim, Donghyun Kim, Jong Hwan Sung
Summary: Recent research indicates that the gut luminal environment can impact behavior, emotion, and cognitive abilities in the brain via various signaling pathways, with exosomes potentially mediating the communication. Advances in organ-on-a-chip technology have led to the development of a modular microfluidic chip for studying the interaction between the gut and the brain, which showed promise in facilitating the transport of exosomes across barriers. This model represents a novel in vitro approach to studying Gut-Brain Axis interactions.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ding Yang, Zixu Wang, Yaoxing Chen, Qingyun Guo, Yulan Dong
Summary: The role of the gut-brain axis in maintaining homeostasis of the brain and gut has been recognized. The NLRP3 inflammasome plays a crucial role in coordinating host physiology and immunity. More research is needed to determine the causal link between gut microbiota structure and NLRP3 activation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yadav S. Bajagai, Jason C. Steel, Anita Radovanovic, Dragana Stanley
Summary: Herbs and spices, traditionally used for medicinal purposes, are regaining popularity due to increasing interest in health, natural products, and nutrition. The ban on antibiotics in the livestock industry has highlighted the need for alternative medicines with antimicrobial properties. Studies on the nutrigenomic effects of prolonged herb use could have significant implications for disease management and therapy.
Review
Endocrinology & Metabolism
Filipe M. Ribeiro, Maycon A. Silva, Victoria Lyssa, Gabriel Marques, Henny K. Lima, Octavio L. Franco, Bernardo Petriz
Summary: Obesity is a major pandemic that requires various actions for treatment, including dietary intervention and physical exercise. Excessive fat accumulation leads to health problems associated with the gut-microbiota-brain axis, which involves communication between intestinal bacteria and the brain. Exercise acts as a rebalancing agent for this axis, preventing chronic low-grade inflammation induced by obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Heather Hulme, Lynsey M. Meikle, Nicole Strittmatter, John Swales, Gregory Hamm, Sheila L. Brown, Simon Milling, Andrew S. MacDonald, Richard J. A. Goodwin, Richard Burchmore, Daniel M. Wall
Summary: Microbes have significant effects on the levels of neurotransmitters and their precursors in the brain. Antibiotic treatment does not cause significant changes in these metabolites in the brain.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Biochemistry & Molecular Biology
Majid Davidson, Marina Mayer, Amanda Habib, Niloufar Rashidi, Rhiannon Talia Filippone, Sarah Fraser, Monica D. Prakash, Puspha Sinnayah, Kathy Tangalakis, Michael L. Mathai, Kulmira Nurgali, Vasso Apostolopoulos
Summary: This study aimed to understand the complex interactions of the gastrointestinal-immune-nervous systems following acute methamphetamine (METH) administration, focusing on the impact of METH abuse on gut permeability. The findings showed decreased expression of tight junction proteins in the intestinal tissue, indicating intestinal wall disruption. Inflammatory markers were also higher in METH-treated mice, suggesting METH-induced blood-brain barrier disruption. Additionally, METH treatment led to anxious behavior in mice. These findings provide opportunities to develop effective treatments for METH addiction in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jiayi Liu, Anding Wu, Jingjing Cai, Zhi-Gang She, Hongliang Li
Summary: NAFLD, the liver manifestation of metabolic syndrome, involves various factors such as metabolic disturbances, inflammation, and cell death. The intestinal-liver axis theory suggests a close relationship between changes in intestinal flora and the development of NAFLD, affecting pathways like energy metabolism to regulate the pathogenesis of NAFLD.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
Yvette Tache, Juan M. Saavedra
Summary: This special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications in a variety of neurological disorders.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Qiongqiong Zhang, Peiying Deng, Suhui Chen, Hong Xu, Yamin Zhang, Hui Chen, Jianmin Zhang, Hua Sun
Summary: Electroacupuncture (EA) and iPSC-derived small extracellular vesicles (iPSC-EVs) have beneficial effects on ischemic stroke by regulating the microbiome-gut-brain axis (MGBA) and reducing brain and colon damage. They improve neurological function, downregulate IL-17 expression, upregulate IL-10 levels, modulate microbiota composition and diversity, and positively impact the outcomes of ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Szu-Ju Chen, Chin-Hsien Lin
Summary: Parkinson's disease is the second most common neurodegenerative disease, influenced by both genetic risk and environmental factors. While motor dysfunction is the main characteristic, the disease process involves multiple systems and shows heterogenous clinical presentation and progression. Genetic predisposition to Parkinson's disease includes abnormal immune responses, protein aggregation, autophagolysosomal impairment, and mitochondrial dysfunction, leading to vulnerable neurons that are sensitive to environmental triggers. Changes in the gut microenvironment may potentially act as a trigger in genetically susceptible individuals.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Gastroenterology & Hepatology
Yi Yuan, Xiyang Wang, Shun Huang, Hao Wang, Guoming Shen
Summary: Irritable bowel syndrome is a common gastrointestinal disorder with a multifactorial etiology involving neurological, inflammatory, and immunological changes. There is increasing evidence of low-grade chronic inflammation in irritable bowel patients, which is influenced by the interaction between intestinal immune factors and the brain-gut axis mediated by the microbiota. This review aims to discuss the impact of immune-brain-gut axis-inflammation interactions on irritable bowel syndrome, its clinical relevance, and potential therapeutic approaches.
Article
Gastroenterology & Hepatology
Jiangyue Lu, Shuang Zhang, Yuezhen Huang, Jun Qian, Baochun Tan, Xueshen Qian, Jia Zhuang, Xihong Zou, Yanfen Li, Fuhua Yan
Summary: Periodontitis-related salivary microbiota may exacerbate the pathogenesis of Alzheimer's disease through the gut-brain axis. In this study, the gavage of periodontitis-related salivary microbiota in APP(swe)/PS1(Delta E9) transgenic mice impaired cognitive function, increased beta-amyloid accumulation and neuroinflammation, along with gut microbial dysbiosis, intestinal pro-inflammatory responses, intestinal barrier impairment, and subsequent exacerbation of systemic inflammation.
Article
Nutrition & Dietetics
Katleen Pinchaud, Zeeshan Hafeez, Sandrine Auger, Jean-Marc Chatel, Sead Chadi, Philippe Langella, Justine Paoli, Annie Dary-Mourot, Katy Maguin-Gate, Jean Luc Olivier
Summary: The study found that dietary arachidonic acid can alter gut microbiota, induce low-grade colic inflammation, and cause astrogliosis in the brain.
Review
Medicine, Research & Experimental
Xiaoxu Wang, Yafan Li, Lingjun Wu, Shiju Xiao, Yunrun Ji, Yong Tan, Chunyan Jiang, Guangzhong Zhang
Summary: Psoriasis and depression are believed to be interrelated, and the gut-brain-skin axis may play a crucial role in the overlapping mechanisms between the two conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Nutrition & Dietetics
Giuseppe Marano, Marianna Mazza, Francesco Maria Lisci, Michele Ciliberto, Gianandrea Traversi, Georgios Demetrios Kotzalidis, Domenico De Berardis, Lucrezia Laterza, Gabriele Sani, Antonio Gasbarrini, Eleonora Gaetani
Summary: There is increasing interest in the role of intestinal microbiota and autoimmune processes in psychiatric diseases. Altered communication between the microbiota-gut-brain axis may be a cause of psychiatric disorders. This review explores the evidence for the involvement of gut microbiota in psychiatric diseases and the impact of diet on microbiota and mental health. Changes in gut microbiota composition can lead to increased intestinal permeability, resulting in a cytokine storm, systemic inflammation, and immune response. These events can affect neurotransmitter release, alter the hypothalamic-pituitary-adrenal axis, and reduce trophic brain factors. Further research is needed to understand the underlying mechanisms connecting gut microbiota and psychiatric disorders.
Article
Biochemistry & Molecular Biology
Jessica M. Yano, Kristie Yu, Gregory P. Donaldson, Gauri G. Shastri, Phoebe Ann, Liang Ma, Cathryn R. Nagler, Rustem F. Ismagilov, Sarkis K. Mazmanian, Elaine Y. Hsiao
Article
Cell & Tissue Engineering
Virginie Neirinckx, Gulistan Agirman, Cecile Coste, Alice Marquet, Valerie Dion, Bernard Rogister, Rachelle Franzen, Sabine Wislet
STEM CELL RESEARCH & THERAPY
(2015)
Review
Biochemistry & Molecular Biology
Gulistan Agirman, Loic Broix, Laurent Nguyen
Article
Biochemistry & Molecular Biology
Carla G. Silva, Elise Peyre, Mohit H. Adhikari, Sylvia Tielens, Sebastian Tanco, Petra Van Damme, Lorenza Magno, Nathalie Krusy, Gulistan Agirman, Maria M. Magiera, Nicoletta Kessaris, Brigitte Malgrange, Annie Andrieux, Carsten Janke, Laurent Nguyen
Article
Multidisciplinary Sciences
G. P. Donaldson, M. S. Ladinsky, K. B. Yu, J. G. Sanders, B. B. Yoo, W. -C. Chou, M. E. Conner, A. M. Earl, R. Knight, P. J. Bjorkman, S. K. Mazmanian
Article
Multidisciplinary Sciences
Cecile Coste, Virginie Neirinckx, Anil Sharma, Gulistan Agirman, Bernard Rogister, Jacques Foguenne, Francois Lallemend, Andre Gothot, Sabine Wislet
Article
Multidisciplinary Sciences
L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fievre, P. Oberst, G. Bartolini, I. Vitali, C. Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon
Article
Neurosciences
Polina Oberst, Gulistan Agirman, Denis Jabaudon
CURRENT OPINION IN NEUROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Yiqiao Wang, Haohao Wu, Paula Fontanet, Simone Codeluppi, Natalia Akkuratova, Charles Petitpre, Yongtao Xue-Franzen, Karen Niederreither, Anil Sharma, Fabio Da Silva, Glenda Comai, Gulistan Agirman, Domenico Palumberi, Sten Linnarsson, Igor Adameyko, Aziz Moqrich, Andreas Schedl, Gioele La Manno, Saida Hadjab, Francois Lallemend
NATURE COMMUNICATIONS
(2019)
Editorial Material
Biochemistry & Molecular Biology
Gulistan Agirman, Elaine Y. Hsiao
Review
Medicine, Research & Experimental
Kristie B. Yu, Elaine Y. Hsiao
Summary: The gut microbiota can influence host appetite by modulating food preference and interacting with neural pathways involving neurotransmitters and neuropeptides. Understanding the roles of gut microbes in feeding regulation is crucial for developing therapeutic strategies for metabolic and eating disorders.
JOURNAL OF CLINICAL INVESTIGATION
(2021)