Article
Biochemical Research Methods
Qian Chen, Tian Jin, Weizhi Qi, Lei Xi
Summary: Observing microscale neurovascular dynamics under different physiological conditions is important for understanding brain functions. A dual-model wearable device integrating high-resolution photoacoustic microscopy and EEG allowed observation of capillary-level hemodynamics and neural activities in rats. Anesthesia had a dominant impact on seizure onset and affected the neurovascular coupling correlation.
BIOMEDICAL OPTICS EXPRESS
(2021)
Review
Biochemistry & Molecular Biology
Yoon Kyung Choi
Summary: The neurovascular system in the eye is crucial in aging-related eye diseases, and vascular damage is associated with various diseases. Preventing or slowing down pathological processes can be beneficial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
K. Shaw, L. Bell, K. Boyd, D. M. Grijseels, D. Clarke, O. Bonnar, H. S. Crombag, C. N. Hall
Summary: This study compared neurovascular function in awake mice between the hippocampus and cortex, revealing decreased blood flow, blood oxygenation, and neurovascular coupling in the hippocampus due to differences in vascular network and microvascular cell function.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Adam Institoris, Milene Vandal, Govind Peringod, Christy Catalano, Cam Ha Tran, Xinzhu Yu, Frank Visser, Cheryl Breiteneder, Leonardo Molina, Baljit S. Khakh, Minh Dang Nguyen, Roger J. Thompson, Grant R. Gordon
Summary: Functional hyperemia, the process of increasing local cerebral blood flow to meet regional energy demand, is mediated by astrocyte Ca2+ signaling and shows distinct early and late components. Astrocyte Ca2+ plays a fundamental role in amplifying functional hyperemia during sustained neuronal activation.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Ameer A. Haider, Tonia S. Rex, Lauren K. Wareham
Summary: Glaucoma is an age-related disease that leads to irreversible blindness worldwide. Currently, only intraocular pressure (IOP) can be modified to reduce the risk of the disease, but the pathology still progresses. It has been found that vascular dysfunction is associated with glaucoma, and the signaling of nitric oxide-cyclic guanosine monophosphate (NO-cGMP) plays a significant role in glaucomatous neurodegeneration.
Review
Biochemistry & Molecular Biology
Mustapha Irnaten, Colm J. O'Brien
Summary: Glaucoma is a common cause of treatable visual impairment, affecting millions of people worldwide. In this study, we investigated the role of calcium signaling in glaucomatous lamina cribrosa (LC) cells and found evidence of oxidative stress, mitochondrial dysfunction, and an abnormal rise in cytosolic calcium. This abnormal calcium signaling was dependent on calcium entry channels and released from internal stores in the endoplasmic reticulum and mitochondria. Further research in this area may help identify potential therapeutic targets for optic neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Ravi L. Rungta, Marc Zuend, Ali-Kemal Aydin, Eric Martineau, Davide Boido, Bruno Weber, Serge Charpak
Summary: This study found functional diversity in neuronal activation-triggered vascular events not only between different brain regions but also at the level of different vascular arbours within supragranular layers of the cerebral cortex. The spatial-temporal sequence of vascular events showed significant variability across compartments of different vascular arbours.
COMMUNICATIONS BIOLOGY
(2021)
Review
Ophthalmology
Luis Alarcon-Martinez, Yukihiro Shiga, Deborah Villafranca-Baughman, Jorge L. Cueva Vargas, Isaac A. Vidal Paredes, Heberto Quintero, Brad Fortune, Helen Danesh-Meyer, Adriana Di Polo
Summary: Understanding the mechanisms of neurovascular interactions is essential for improving functional outcomes in glaucoma. The neurovascular unit, comprising various cell types, regulates processes such as blood flow and neurovascular coupling. Recent studies have highlighted the role of pericytes and the discovery of tunneling nanotubes in the spatial and temporal distribution of blood within the retinal capillary network. Strategies targeting vascular protection and regeneration may hold potential for improving outcomes in glaucoma.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Review
Neurosciences
Cam Ha T. Tran
Summary: This article highlights the currently available genetic and imaging tools for studying the NVU and NVC, with a focus on astrocyte Ca2+ dynamics and vascular activity, and discusses the utility, technical advantages, and limitations of these tools for elucidating NVC mechanisms.
Article
Cell Biology
Koji Ando, Lei Tong, Di Peng, Elisa Vazquez-Liebanas, Hirohisa Chiyoda, Liqun He, Jianping Liu, Koichi Kawakami, Naoki Mochizuki, Shigetomo Fukuhara, Jaime Grutzendler, Christer Betsholtz
Summary: Loss- or gain-of-function mutations in ATP-sensitive potassium channel (K-ATP)-encoding genes, KCNJ8 and ABCC9, can cause central nervous system disorders. This study shows that KCNJ8/ABCC9-containing K-ATP channels play a role in the differentiation of brain vascular smooth muscle cells (VSMCs) and the regulation of cerebral blood flow.
DEVELOPMENTAL CELL
(2022)
Article
Neurosciences
Jing Hong Loo, Ying Shi Lee, Chang Yi Woon, Victor H. K. Yong, Bingyao Tan, Leopold Schmetterer, Rachel S. Chong
Summary: Glaucoma is a neurodegenerative disease associated with intraocular pressure, with recent studies suggesting a link to disturbances in neurovascular coupling. Loss of Cav-1 may predispose to vascular dysfunction and reduced RGC signaling.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Sebastian Sten, Henrik Podeus, Nicolas Sundqvist, Fredrik Elinder, Maria Engstrom, Gunnar Cedersund
Summary: The study develops a comprehensive neurovascular coupling (NVC) model by combining experimental data from mice, monkeys, and humans, and propagates qualitative insights from each species to the subsequent analysis of data from other species. The model unravels the role of different neuronal sub-populations in mice and applies these insights to analyze primate and human data. This work demonstrates the integration of data with complementary information from different species for a new type of integrative analysis of human data.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jae-Min Lee, Joo Hee Lee, So Hee Kim, Tae Hyeok Sim, Youn-Jung Kim
Summary: Vascular aging is associated with neurovascular unit breakdown, oxidative stress, and cognitive dysfunction. We developed an aptamer, NXP032, that enhances the function of vitamin C and investigated its effects on neurovascular stabilization in aged mice. NXP032 treatment reduced blood-brain barrier damage, attenuated microvessel fragmentation, and mitigated astrocytes and microglia activation. This study suggests that NXP032 may be a novel intervention for aging-induced cognitive impairment.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Jake M. Cashion, Kaylene M. Young, Brad A. Sutherland
Summary: Multiple sclerosis is a common non-traumatic cause of neurological disability in young adults, characterized by inflammatory demyelination in the central nervous system. Despite the availability of disease-modifying therapies, current treatments are unable to prevent neurodegeneration and disease progression, highlighting the need to understand the underlying cause of multiple sclerosis. Risk factors such as vitamin D deficiency, cigarette smoking, and youth obesity, which also affect vascular health, have been identified. The dysfunction of the neurovascular unit, which regulates neuroinflammation, blood-brain barrier integrity, and cerebral blood flow, may play a crucial role in multiple sclerosis development and progression.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Boily, Lin Li, Diane Vallerand, Helene Girouard
Summary: The study revealed that Angiotensin II impairs neurovascular coupling by enhancing astrocytic calcium responses, promoting vasoconstriction over vasodilation and altering cerebral blood flow increases in response to neuronal activity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Neurosciences
Marius Chiasseu, Jorge L. Cueva Vargas, Laurie Destroismaisons, Christine Vande Velde, Nicole Leclerc, Adriana Di Polo
JOURNAL OF NEUROSCIENCE
(2016)
Editorial Material
Cell Biology
Jorge L. Cueva Vargas, Adriana Di Polo
NEURAL REGENERATION RESEARCH
(2016)
Article
Neurosciences
Jorge L. Cueva Vargas, Nicolas Belforte, Adriana Di Polo
NEUROBIOLOGY OF DISEASE
(2016)
Article
Multidisciplinary Sciences
Yoko A. Ito, Nicolas Belforte, Jorge L. Cueva Vargas, Adriana Di Polo
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Neurosciences
Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Polo
MOLECULAR NEURODEGENERATION
(2017)
Article
Biotechnology & Applied Microbiology
Elizabeth M. Simpson, Andrea J. Korecki, Oriol Fornes, Trevor J. McGill, Jorge Luis Cueva-Vargas, Jessica Agostinone, Rachelle A. Farkas, Jack W. Hickmott, Siu Ling Lam, Anthony Mathelier, Lauren M. Renner, Jonathan Stoddard, Michelle Zhou, Adriana Di Polo, Martha Neuringer, Wyeth W. Wasserman
HUMAN GENE THERAPY
(2019)
Article
Multidisciplinary Sciences
Manuel Flores Molina, Thomas Fabre, Aurelie Cleret-Buhot, Genevieve Soucy, Liliane Meunier, Mohamed N. Abdelnabi, Nicolas Belforte, Simon Turcotte, Naglaa H. Shoukry
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Biochemistry & Molecular Biology
Andrea J. Korecki, Jorge L. Cueva-Vargas, Oriol Fornes, Jessica Agostinone, Rachelle A. Farkas, Jack W. Hickmott, Siu Ling Lam, Anthony Mathelier, Michelle Zhou, Wyeth W. Wasserman, Adriana Di Polo, Elizabeth M. Simpson
Summary: The researchers designed 19 human DNA MiniPromoters using bioinformatics, tested them in mice, and presented a new resource for ocular gene therapy. The MiniPromoters showed potential for use in therapies involving small regulatory RNA and DNA, as well as proteins.
Article
Neurosciences
Nicolas Belforte, Jessica Agostinone, Luis Alarcon-Martinez, Deborah Villafranca-Baughman, Florence Dotigny, Jorge L. Cueva Vargas, Adriana Di Polo
Summary: The study identified AMPK as a critical mediator between bioenergetic decline and RGC dysfunction in pressure-induced stress, showing that AMPK activation leads to RGC dendrite retraction and synapse elimination through inhibition of mTORC1. Attenuation of AMPK activity restores mTORC1 function and rescues dendrites and synaptic contacts, promoting recovery of light-evoked retinal responses and extending RGC survival.
MOLECULAR NEURODEGENERATION
(2021)
Review
Ophthalmology
Luis Alarcon-Martinez, Yukihiro Shiga, Deborah Villafranca-Baughman, Jorge L. Cueva Vargas, Isaac A. Vidal Paredes, Heberto Quintero, Brad Fortune, Helen Danesh-Meyer, Adriana Di Polo
Summary: Understanding the mechanisms of neurovascular interactions is essential for improving functional outcomes in glaucoma. The neurovascular unit, comprising various cell types, regulates processes such as blood flow and neurovascular coupling. Recent studies have highlighted the role of pericytes and the discovery of tunneling nanotubes in the spatial and temporal distribution of blood within the retinal capillary network. Strategies targeting vascular protection and regeneration may hold potential for improving outcomes in glaucoma.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
