Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

(2020) Mohammad Shahnawaz et al.   NATURE

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

(2020) Anke Van der Perren et al.   ACTA NEUROPATHOLOGICA

Evidence of distinct α-synuclein strains underlying disease heterogeneity

(2020) Sara A. M. Holec et al.   ACTA NEUROPATHOLOGICA

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

(2019) Marius Kollmer et al.   Nature Communications

Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of α-Synuclein

(2019) Hanae Yamamoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

(2019) Timo Strohäker et al.   Nature Communications

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of the 3D Structures of Mouse and Human α-Synuclein Fibrils by Solid-State NMR and STEM

(2018) Songhwan Hwang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods

(2018) Airi Tarutani et al.   Acta Neuropathologica Communications

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

(2018) Bradley R. Groveman et al.   Acta Neuropathologica Communications

Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics

(2018) Tritia R. Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication

(2017) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

(2015) Thomas G. Beach et al.   NEUROPATHOLOGY

Propagation of prions causing synucleinopathies in cultured cells

(2015) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

(2014) Amanda N. Sacino et al.   ACTA NEUROPATHOLOGICA

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Transmission of multiple system atrophy prions to transgenic mice

(2013) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson's Disease and Parkinsonism: Neuropathology

(2013) D. W. Dickson   Cold Spring Harbor Perspectives in Medicine

Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium

(2009) Irina Alafuzoff et al.   ACTA NEUROPATHOLOGICA

Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein

(2009) H. Wille et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Second consensus statement on the diagnosis of multiple system atrophy

(2008) S. Gilman et al.   NEUROLOGY