Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors

GPCRdb in 2021: integrating GPCR sequence, structure and function

(2020) Albert J Kooistra et al.   NUCLEIC ACIDS RESEARCH

The emergence of melatonin in oncology: Focus on colorectal cancer

(2019) Emilio Gil‐Martín et al.   MEDICINAL RESEARCH REVIEWS

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

(2019) Victoria Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

(2019) Francesco Raimondi et al.   ONCOGENE

Olfactory receptor gene abundance in invasive breast carcinoma

(2019) Shirin Masjedi et al.   Scientific Reports

GPCRs: Emerging anti-cancer drug targets

(2018) Ainhoa Nieto Gutierrez et al.   CELLULAR SIGNALLING

Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer

(2018) Lea Weber et al.   Frontiers in Physiology

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

(2018) Kyle Ellrott et al.   Cell Systems

Therapeutic potential of ectopic olfactory and taste receptors

(2018) Sung-Joon Lee et al.   NATURE REVIEWS DRUG DISCOVERY

Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line

(2017) Benjamin Kalbe et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis

(2017) Lian Gelis et al.   EXPERIMENTAL DERMATOLOGY

Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis

(2017) Lea Weber et al.   PLoS One

Melatonin for the prevention and treatment of cancer

(2017) Ya Li et al.   Oncotarget

Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples

(2017) Thomas A. Peterson et al.   PLoS Computational Biology

Genetic variants affecting equivalent protein family positions reflect human diversity

(2017) Francesco Raimondi et al.   Scientific Reports

Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation

(2016) Yun-Min Sung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Reduction in Circulating Melatonin Level May Contribute to the Pathogenesis of Ovarian Cancer: A Retrospective Study

(2016) Min Zhao et al.   Journal of Cancer

Urinary Melatonin Levels, Sleep Disruption, and Risk of Prostate Cancer in Elderly Men

(2015) Lara G. Sigurdardottir et al.   EUROPEAN UROLOGY

Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA-217-KRAS Axis

(2015) Xian Zhang et al.   MOLECULES AND CELLS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor

(2015) Sean M. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations

(2015) Fan Yang et al.   PLoS Computational Biology

Pan-Cancer Analysis of Mutation Hotspots in Protein Domains

(2015) Martin L. Miller et al.   Cell Systems

Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature

(2014) Michelle Basler et al.   Breast Care

A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness

(2014) Panagiotis Katsonis et al.   GENOME RESEARCH

Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells

(2014) Luke H. Hoeppner et al.   Molecular Oncology

Unifying Family A GPCR Theories of Activation

(2014) Benjamin G. Tehan et al.   PHARMACOLOGY & THERAPEUTICS

Single nucleotide variations: Biological impact and theoretical interpretation

(2014) Panagiotis Katsonis et al.   PROTEIN SCIENCE

VarWalker: Personalized Mutation Network Analysis of Putative Cancer Genes from Next-Generation Sequencing Data

(2014) Peilin Jia et al.   PLoS Computational Biology

Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes

(2014) Sheli L. Ostrow et al.   PLoS Genetics

Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders

(2013) Tian-Rui Xu et al.   CELLULAR SIGNALLING

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

GPCRs and cancer

(2012) Rosamaria Lappano et al.   ACTA PHARMACOLOGICA SINICA

The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials

(2012) Ye-min Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The use of evolutionary patterns in protein annotation

(2012) Angela D. Wilkins et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Orexin A Suppresses the Growth of Rat C6 Glioma Cells via a Caspase-Dependent Mechanism

(2012) Kaja Biegańska et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Involvement of β-arrestins in cancer progression

(2012) Shanshan Hu et al.   MOLECULAR BIOLOGY REPORTS

Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis

(2011) T. Voisin et al.   CANCER RESEARCH

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors

(2010) Gustavo J. Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization

(2009) Aya Kato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activation of an Olfactory Receptor Inhibits Proliferation of Prostate Cancer Cells

(2009) Eva M. Neuhaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary Trace Annotation of Protein Function in the Structural Proteome

(2009) Serkan Erdin et al.   JOURNAL OF MOLECULAR BIOLOGY

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

PROMALS3D: a tool for multiple protein sequence and structure alignments

(2008) Jimin Pei et al.   NUCLEIC ACIDS RESEARCH