期刊
BURNS
卷 41, 期 2, 页码 379-385出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.burns.2014.07.012
关键词
Hydrogen-rich saline resuscitation; Inflammatory reaction; Severe burns; Delayed resuscitation
资金
- National Natural Science Foundation of China [81101427]
Severe bums with delayed resuscitation are associated with high morbidity which is attributed to ischemia-reperfusion injury. This study was undertaken to investigate the effect of hydrogen-rich saline known as a significant selective antioxidant on the inflammatory reaction induced by severe burns with delayed resuscitation. By establishing the model of severe burns with delayed resuscitation in rats, we recorded improvement on the mortality, secretion of cytokines and reaction of oxidative stress of rats treated with hydrogen-rich saline. We found that resuscitation by hydrogen-rich saline alleviated inflammation significantly. We further detected the change of the key nuclear factor NE-kappa B contributed to inflammation. The expression of both NF-kappa B and phosphorylated NF-kappa B in rats having severe bums with delayed resuscitation by hydrogen-rich saline was lower than that in rats with delayed resuscitation with Ringers' solution. Our data imply that hydrogen-rich saline significantly improves the inflammatory reaction in rats with severe bums with delayed resuscitation, possibly by inhibiting activation of NF-kappa B. (C) 2014 Elsevier Ltd and ISBI. All rights reserved.
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