期刊
INNATE IMMUNITY
卷 22, 期 7, 页码 522-533出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1753425916661402
关键词
Agaricus blazei Murrill; Antrodia cinnamomea; caterpillar fungus; extraction; Ganoderma lucidum; Hirsutella sinensis; immunomodulatory effects; innate immunity; medicinal mushrooms; Ophiocordyceps sinensis
资金
- Primordia Institute of New Sciences and Medicine
- Ministry of Science and Technology of Taiwan [MOST103-2320-B-182-027-MY3, MOST-104-2320-B-030-009]
- Chang Gung Memorial Hospital at Linkou [CMRPDm1E0072, CMRPD1F0121, QZRPD120]
Medicinal mushrooms have been used for centuries in Asian countries owing to their beneficial effects on health and longevity. Previous studies have reported that a single medicinal mushroom may produce both stimulatory and inhibitory effects on immune cells, depending on conditions, but the factors responsible for this apparent dichotomy remain obscure. We show here that water and ethanol extracts of cultured mycelium from various species (Agaricus blazei Murrill, Antrodia cinnamomea, Ganoderma lucidum and Hirsutella sinensis) produce opposite effects on NK cells. Water extracts enhance NK cell cytotoxic activity against cancer cells, whereas ethanol extracts inhibit cytotoxicity. Water extracts stimulate the expression and production of cytolytic proteins (perforin and granulysin) and NKG2D/NCR cell surface receptors, and activate intracellular signaling kinases (ERK, JNK and p38). In contrast, ethanol extracts inhibit expression of cytolytic and cell surface receptors. Our results suggest that the mode of extraction of medicinal mushrooms may determine the nature of the immunomodulatory effects produced on immune cells, presumably owing to the differential solubility of stimulatory and inhibitory mediators. These findings have important implications for the preparation of medicinal mushrooms to prevent and treat human diseases.
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