Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

(2019) Feng Zhou et al.   Acta Pharmaceutica Sinica B

Osteoarthritis

(2019) David J Hunter et al.   LANCET

N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis

(2019) Pan Zhou et al.   PHARMACOLOGICAL RESEARCH

Retraction Note: Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model

(2019) H. Qiao et al.   Cell Death & Disease

A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

(2019) Yuanyuan Shi et al.   Nature Communications

Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis

(2019) Kai Sun et al.   Aging-US

Quickly verifying the antioxidant contribution of the individual composition in natural antioxidants by HPLC-free radical scavenging detection

(2018) Lu Wang et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis

(2018) Yuanxu Guo et al.   Cell Death & Disease

Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission

(2018) Xudong Yao et al.   PHARMACOLOGICAL RESEARCH

Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis

(2018) Brett C. Geiger et al.   Science Translational Medicine

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes

(2017) Nazir M. Khan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway

(2017) Zuqiang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Eucalrobusone C suppresses cell proliferation and induces ROS-dependent mitochondrial apoptosis via the p38 MAPK pathway in hepatocellular carcinoma cells

(2017) Kai-Li Jian et al.   PHYTOMEDICINE

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system

(2015) Matthew C. Walsh et al.   IMMUNOLOGICAL REVIEWS

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes

(2015) Heba M. Ismail et al.   Arthritis & Rheumatology

Avicularin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Suppressing ERK Phosphorylation in RAW 264.7 Macrophages

(2013) Van Anh Vo et al.   Biomolecules & Therapeutics

Molecular basis of MAP kinase regulation

(2013) Wolfgang Peti et al.   PROTEIN SCIENCE

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Pro-oxidants ameliorate radiation-induced apoptosis through activation of the calcium–ERK1/2–Nrf2 pathway

(2011) Nazir M. Khan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatoprotective Effect of Flavonoid Glycosides from Lespedeza cuneata against Oxidative Stress Induced by tert-Butyl Hyperoxide

(2011) Sang Min Kim et al.   PHYTOTHERAPY RESEARCH

Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes

(2011) Nahid Akhtar et al.   ARTHRITIS RESEARCH & THERAPY

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

(2009) B.-C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE