期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 377, 期 1844, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2020.0524
关键词
hierarchy; orbitofrontal cortex; premotor cortex; motor cortex; dynamical systems
类别
资金
- National Institute on Drug Abuse [R01 DA038615, MH124687]
This article proposes that the entirety of the prefrontal cortex can be seen as fundamentally premotor in nature, with a hierarchy that revolves around goal-selection. The orbitofrontal cortex is positioned as a key role in optimizing goal-selection policies. This perspective reframes outstanding questions and aligns theories of prefrontal function with evolutionary principles.
We propose that the entirety of the prefrontal cortex (PFC) can be seen as fundamentally premotor in nature. By this, we mean that the PFC consists of an action abstraction hierarchy whose core function is the potentiation and depotentiation of possible action plans at different levels of granularity. We argue that the apex of the hierarchy should revolve around the process of goal-selection, which we posit is inherently a form of optimization over action abstraction. Anatomical and functional evidence supports the idea that this hierarchy originates on the orbital surface of the brain and extends dorsally to motor cortex. Accordingly, our viewpoint positions the orbitofrontal cortex in a key role in the optimization of goal-selection policies, and suggests that its other proposed roles are aspects of this more general function. Our proposed perspective will reframe outstanding questions, open up new areas of inquiry and align theories of prefrontal function with evolutionary principles. This article is part of the theme issue 'Systems neuroscience through the lens of evolutionary theory'.
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