Article
Dermatology
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, G. Avila Valle, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara Pinton, S. Christen-Zach, M. Deleuran, M. Dittmann, C. Dressler, A. H. Fink-Wagner, N. Fosse, K. Gaspar, L. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, C. G. Mortz, A. Nast, U. Nygaard, M. Redding, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra-Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, C. Flohr
Summary: The evidence- and consensus-based guideline on atopic eczema, developed according to the EuroGuiDerm Guideline and Consensus Statement Development Manual, involves the participation of 29 experts from 12 European countries. The first part of the guideline provides general information, guidance, and detailed information on systemic treatment options, including conventional immunosuppressive drugs, biologics, and janus kinase inhibitors. The second part will cover other aspects of treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jamie Afghani, Claudia Traidl-Hoffmann, Philippe Schmitt-Kopplin, Matthias Reiger, Constanze Mueller
Summary: Atopic eczema is an inflammatory skin disorder that affects approximately 20% of children worldwide, and early onset can lead to other allergic diseases. Metabolomics can be used to observe the mechanisms of this disease and potentially discover new drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Developmental
Karima M. Osman, Pauline Gerard, Elijah W. Hale
Summary: ADHD and ASD have associations with common dermatologic conditions. Males with ADHD or ADHD/ASD have an increased prevalence of acne, and all neurodivergent males have an increased prevalence of eczema. Females with ADHD have an increase in both conditions. Females with ADHD/ASD show no significant differences, and females with ASD have a decreased risk of eczema.
JOURNAL OF ATTENTION DISORDERS
(2023)
Letter
Dermatology
Nicole S. Stefanko, Victor L. Quan, Raj Chovatiya
Summary: This study investigates the diagnostic delay in an autoimmune skin disease. The use of C3d and C4d immunohistochemistry is found to be a valuable tool in the diagnosis of inflammatory skin diseases.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Allergy
Raj Chovatiya, Amy S. Paller
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options. Recent studies have shown that both topical and systemic Janus kinase (JAK) inhibitors hold promise in treating AD, with further research needed to fully understand their efficacy and safety.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Anne Birgitte Simonsen, Jojo Biel-Nielsen Dietz, Jeanne Duus Johansen
Summary: This study aimed to explore the epidemiology, aetiology and severity of hand eczema (HE) among Danish adolescents. The study found a high prevalence of HE among Danish adolescents, raising concerns about this significant clinical problem.
CONTACT DERMATITIS
(2023)
Review
Immunology
Paola Facheris, Jane Jeffery, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis (AD) is a complex and heterogeneous inflammatory skin disease. Different phenotypes of AD based on patient characteristics have been defined, emphasizing the need for personalized treatment. Advances in understanding AD pathogenesis have led to an expansion in therapeutic options. Biomarkers in clinical studies are helping to clarify the role of cytokines and immune pathways in AD and enable personalized medicine. This review discusses changes in the understanding and treatment of AD, highlighting the scientific rationale behind targeted treatments and presenting recent clinical efficacy data.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Justin Choi, Nishadh Sutaria, Youkyung Sophie Roh, Zachary Bordeaux, Martin P. Alphonse, Shawn G. Kwatra, Madan M. Kwatra
Summary: The complexity of atopic dermatitis poses a challenge in selecting an appropriate mouse model, as no single model can fully replicate all aspects of the human condition. Recent evidence has identified distinct endotypes of AD, characterized by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. While all AD mouse models consistently show Th2 inflammation, only some also exhibit Th17 and/or Th22 induction, highlighting the need for a closer evaluation of their immunological signature to enhance their relevance to human AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Alice Plant, Michael R. Ardern-Jones
Summary: Atopic dermatitis is a common inflammatory skin disease characterized by itch, which can significantly impact quality of life and persist into adulthood. General physicians must recognize the disease to differentiate acute flares from other conditions, such as eczema herpeticum and allergic reactions. While current treatments focus on broad spectrum immunomodulation, advancements in understanding the disease's pathophysiology have expanded treatment options, with promising new drugs offering potential for more effective and safe therapies in the future.
Review
Medicine, Research & Experimental
Marlenne Marisol Garcia-Reyes, Luis Carlos Zumaya-Perez, Rodolfo Pastelin-Palacios, Mario Adan Moreno-Eutimio
Summary: This meta-analysis examines the levels of TSLP in AD patients and controls. The findings suggest that TSLP levels are significantly higher in the AD group, indicating its critical role in the development of AD.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Julius Garcia Gatmaitan, Ji Hyun Lee
Summary: Atopic dermatitis is a complex condition with various factors affecting its treatment and management. In addition to conventional therapies, new drugs targeting specific molecular pathways in atopic dermatitis are being developed to address its complex pathophysiology. The efficacy of these drugs depends on factors such as genotype, environmental triggers, microbiome-derived signals, and immune responses. This review highlights the challenges and recent pharmacological developments in atopic dermatitis, aiming for a more personalized therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias, Sandrine Dubrac
Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yuliya Lytvyn, Asfandyar Mufti, Abrahim Abduelmula, Muskaan Sachdeva, Khalad Maliyar, Jorge R. Georgakopoulos, Jensen Yeung
Summary: Atopic dermatitis is a common skin condition with limited treatment options. Janus kinase inhibitors have been shown to be effective and safe for treating moderate-to-severe atopic dermatitis. Awareness of the clinical evidence is important for dermatologists to improve patient outcomes.
Editorial Material
Medicine, General & Internal
Hui Ling Foo, Hong Liang Tey
Summary: Recent research on atopic dermatitis has identified it as a heterogeneous inflammatory skin disorder with different immune polarisation and genetic mutations, leading to the development of endotype-driven management. A practical approach has been proposed to classify patients into intrinsic and extrinsic phenotypes for targeted management based on underlying endotypes.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2021)
Article
Allergy
Simon de Lusignan, Helen Alexander, Conor Broderick, John Dennis, Andrew McGovern, Claire Feeney, Carsten Flohr
Summary: There is an increased risk of developing autoimmune conditions among individuals newly diagnosed with AD, especially those with more severe AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Dermatology
Charlene Lam, Kassidy Shumaker, Melissa Butt, Paul Leiphart, Jeffery J. Miller, Bryan E. Anderson
Summary: In an academic dermatology and Mohs surgery setting, medical scribes increased clinician satisfaction without compromising patient satisfaction.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Letter
Dermatology
Bryan Moore, Abigail Washington, Melissa Butt, Colleen Silva, Brian Green, Matthew Helm
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
M. Butt, V. M. Chinchilli, D. L. Leslie, E. Khesroh, M. F. Helm, A. Flamm, J. S. Kirby, A. Rigby
Summary: This study validates the validity and reliability of the Internalized Skin Bias Questionnaire (ISBQ) in an HS population and finds that ISB has a prevalent negative impact on the psychopathology of HS patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Megan H. Noe, Marilyn T. Wan, Arash Mostaghimi, Joel M. Gelfand
Summary: This study described the clinical characteristics, treatments, and health care utilization in adults with PPP in the US, highlighting the persistent symptoms, high health care utilization, and lack of consensus on effective treatments in this population. Additional research is needed to understand treatment responses in these patients.
Article
Dermatology
Meaghan C. Dougher, Melissa Butt, Klaus F. Helm, Matthew F. Helm
Summary: This study aimed to evaluate whether the length of clinician training or type of residency training had an impact on the average biopsy size and sample adequacy. The study found that biopsy size decreased with increased experience in dermatology training, but there was no evidence to suggest that this trend currently threatens sample adequacy.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Catherine Smiley, Andrew Strunk, Melissa Butt, Joslyn Kirby, Amit Garg
Summary: This study evaluated the validity of using diagnosis codes to establish HS and CA cohorts, and concluded that patients with at least one HS diagnosis code and no CA diagnosis codes can be accurately determined as HS patients, while patients with at least one CA diagnosis code and no HS diagnosis codes can be mostly determined as CA patients. The positive predictive values of these algorithms for HS and CA were 88% and 75.0% respectively.
Article
Education & Educational Research
Lindsay B. B. Yeh, Melissa Butt, Elaine T. T. McDonnell
Summary: The study found that alternative service methods, particularly breakfast in the classroom, are associated with increased participation in school breakfast programs, leading to improved access to adequate nutrition and food security for school children.
JOURNAL OF SCHOOL HEALTH
(2023)
Article
Surgery
Melissa Butt, Riley A. A. Eisler, Antoinette Hu, Ann M. M. Rogers, Andrea Rigby
Summary: This study investigated the incidence rates of new-onset substance use disorders (SUD) among adults who underwent bariatric surgery and compared them with the general population and individuals diagnosed with overweight or obesity. The results showed that patients who underwent bariatric surgery had a lower risk of developing SUD compared to the general population and individuals with overweight or obesity. However, efforts should still be made to address new-onset SUD in order to optimize post-surgical care.
Letter
Dermatology
Galen T. Foulke, Abigail Washington, Steven Maczuga, Melissa Butt, Arun Kannappan, Matthew F. Helm
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Surgery
Antoinette Hu, Alexandra Harvey, Ann M. Rogers, Andrea Rigby, Melissa Butt
Summary: This study examined the impact of the COVID-19 pandemic on eating behaviors, dietary quality, and weight changes among postoperative bariatric surgery patients. The results showed that most patients did not exhibit symptoms of binge eating, but some experienced loss of control eating. Loss of control eating was associated with grazing behavior, emotional over-eating, and food responsiveness, and negatively related to dietary quality and satiety responsiveness. Slow eating was negatively associated with grazing behavior, emotional overeating, and food responsiveness. Emotional overeating was a significant predictor of weight recurrence.
Review
Pediatrics
Melissa Butt, Alexandra Harvey, Eiman Khesroh, Andrea Rigby, Ian M. M. Paul
Summary: This study aimed to review the topic of internalized weight bias (IWB) among children and adolescents, identify the instruments used to measure IWB, and explore the associated comorbid variables. The findings suggest that IWB is significantly associated with maladaptive eating behaviors and adverse psychopathology in children.
Letter
Dermatology
Lauren C. Hollins, Ryan P. Murphy, Galen Foulke, Melissa Butt, Steven Maczuga, Matthew Helm
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Nutrition & Dietetics
Melissa Butt, Paddy Ssentongo, Ann M. Rogers, Andrea Rigby
Summary: This study examines the associations between food addiction, binge eating disorder, and other appetitive traits, as well as dietary quality in adults with obesity seeking bariatric surgery. The findings suggest that food addiction and binge eating disorder may represent different cognitions and behaviors.
Article
Nutrition & Dietetics
Daisuke Hayashi, Travis D. Masterson, Ann M. Rogers, Andrea Rigby, Melissa Butt
Summary: This study aimed to evaluate the psychometric properties of the REAP-S in a pre-surgical bariatric population. A total of 587 adult patients were included in this analysis, and the results showed that the REAP-S had good internal consistency, but overall the dietary quality was moderate.
