Nanomaterial- and shape-dependency of TLR2 and TLR4 mediated signaling following pulmonary exposure to carbonaceous nanomaterials in mice

Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis

(2021) Sai-nan Chen et al.   ACTA PHARMACOLOGICA SINICA

Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety

(2020) James G. Cronin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

(2020) Sabina Halappanavar et al.   Particle and Fibre Toxicology

Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease

(2020) Niels Hadrup et al.   Small

A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide

(2020) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses

(2019) Niels Hadrup et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

TLRs in pulmonary diseases

(2019) Shweta Arora et al.   LIFE SCIENCES

Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice

(2019) Niels Hadrup et al.   Nanotoxicology

Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion

(2019) Xuejing Cui et al.   TOXICOLOGICAL SCIENCES

Increased surface area of halloysite nanotubes due to surface modification predicts lung inflammation and acute phase response after pulmonary exposure in mice

(2019) Kenneth Klingenberg Barfod et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Effects of physicochemical properties of TiO2 nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice

(2019) Pernille Høgh Danielsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Gold nanoparticles induce serum amyloid A 1–Toll-like receptor 2 mediated NF- k B signaling in lung cells in vitro

(2018) Cheng Teng Ng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Primary genotoxicity in the liver following pulmonary exposure to carbon black nanoparticles in mice

(2018) Justyna Modrzynska et al.   Particle and Fibre Toxicology

Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors

(2018) Sourav P. Mukherjee et al.   Scientific Reports

Physicochemical predictors of Multi-Walled Carbon Nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different Multi-Walled Carbon Nanotubes in mice

(2018) Kristina Bram Knudsen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Serum amyloid A – a review

(2018) George H. Sack   MOLECULAR MEDICINE

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles

(2017) Niels Hadrup et al.   MUTAGENESIS

Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection

(2017) Christine Sattler et al.   Particle and Fibre Toxicology

Nanoparticles and innate immunity: new perspectives on host defence

(2017) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice

(2017) Sarah S. Poulsen et al.   PLoS One

Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide

(2017) Stefan Bengtson et al.   PLoS One

Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults

(2016) Mieke Buck et al.   CURRENT MEDICINAL CHEMISTRY

No cytotoxicity or genotoxicity of graphene and graphene oxide in murine lung epithelial FE1 cells in vitro

(2016) Stefan Bengtson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Carbon nanotubes from synthesis to in vivo biomedical applications

(2016) Muhammad Imran Sajid et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Surface modification does not influence the genotoxic and inflammatory effects of TiO2nanoparticles after pulmonary exposure by instillation in mice

(2016) Håkan Wallin et al.   MUTAGENESIS

Multi-walled carbon nanotube physicochemical properties predict pulmonary inflammation and genotoxicity

(2016) Sarah S. Poulsen et al.   Nanotoxicology

Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammatory and angiogenic mechanisms

(2015) Mary Connolly et al.   ANNALS OF THE RHEUMATIC DISEASES

The Molecular Influence of Graphene and Graphene Oxide on the Immune System Under In Vitro and In Vivo Conditions

(2015) Ilona Dudek et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

(2015) Consol Farrera et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories

(2015) Nicklas Raun Jacobsen et al.   FOOD AND CHEMICAL TOXICOLOGY

Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems

(2015) Andrea C. Ferrari et al.   Nanoscale

Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice

(2015) Mainul Husain et al.   Nanotoxicology

No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice

(2015) Shanze Chen et al.   Particle and Fibre Toxicology

Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats

(2015) Tatsuya Kasai et al.   Particle and Fibre Toxicology

Biodistribution and toxicity of radio-labeled few layer graphene in mice after intratracheal instillation

(2015) Liang Mao et al.   Particle and Fibre Toxicology

Carbon black nanoparticles induce biphasic gene expression changes associated with inflammatory responses in the lungs of C57BL/6 mice following a single intratracheal instillation

(2015) Mainul Husain et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

(2015) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease

(2015) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

(2015) Marina E Vance et al.   Beilstein Journal of Nanotechnology

Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes

(2014) Jie Dong et al.   ARCHIVES OF TOXICOLOGY

DNA damage following pulmonary exposure by instillation to low doses of carbon black (Printex 90) nanoparticles in mice

(2014) Zdenka O. Kyjovska et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line

(2014) Petra Jackson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

Immunotoxicity of nanoparticles: a computational study suggests that CNTs and C60 fullerenes might be recognized as pathogens by Toll-like receptors

(2014) M. Turabekova et al.   Nanoscale

Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers

(2014) Rong Zhang et al.   Particle and Fibre Toxicology

Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease

(2014) Anne T. Saber et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Particle-Induced Pulmonary Acute Phase Response Correlates with Neutrophil Influx Linking Inhaled Particles and Cardiovascular Risk

(2013) Anne Thoustrup Saber et al.   PLoS One

Transcriptomic Analysis Reveals Novel Mechanistic Insight into Murine Biological Responses to Multi-Walled Carbon Nanotubes in Lungs and Cultured Lung Epithelial Cells

(2013) Sarah Søs Poulsen et al.   PLoS One

Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation

(2013) Mainul Husain et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

(2012) Subhankar Chakraborty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver

(2012) Julie A Bourdon et al.   Particle and Fibre Toxicology

Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint

(2012) Anne Saber et al.   Particle and Fibre Toxicology

Clear and present danger? Engineered nanoparticles and the immune system

(2012) B Fadeel   SWISS MEDICAL WEEKLY

Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: A toxicogenomic study

(2011) Sabina Halappanavar et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Size-Dependent Attenuation of TLR9 Signaling by Gold Nanoparticles in Macrophages

(2011) C.-Y. Tsai et al.   JOURNAL OF IMMUNOLOGY

Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice

(2011) J. L. Ather et al.   JOURNAL OF IMMUNOLOGY

Identification of Systemic Markers from A Pulmonary Carbon Nanotube Exposure

(2011) Aaron Erdely et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Exposure of pregnant mice to carbon black by intratracheal instillation: Toxicogenomic effects in dams and offspring

(2011) Petra Jackson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and lacquers

(2011) Anne Thoustrup Saber et al.   Nanotoxicology

An Experimental Protocol for Maternal Pulmonary Exposure in Developmental Toxicology

(2010) Petra Jackson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The role of toll-like receptors in acute and chronic lung inflammation

(2010) Erin I Lafferty et al.   Journal of Inflammation-London

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms involved in ultrafine carbon black-induced release of IL-6 from primary rat epithelial lung cells

(2009) Annike I. Totlandsdal et al.   TOXICOLOGY IN VITRO

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers

(2008) Aaron Erdely et al.   NANO LETTERS