Ameliorative Effect of Graviola Fruit Juice on the Damaged Tissues of Gamma-Irradiated Male Rats

Exposure to ionizing radiation is characterized by production of reactive oxygen species (ROS) associated with increase in lipid peroxidation. Graviola fruits have been reported to possess antioxidant and antiinflammatory activities. The present study was designed to determine the possible protective effects of graviola fruit juice (GFJ) against radiation induced oxidative stress and biochemical alterations in the liver and kidney of male albino rats. In the present study, gamma-irradiation (2 Gy every 3 days up to 8 Gy total doses) induced biochemical and oxidative damage in rats when compared to control group. In GFJ (10ml/Kg B Wt. /day) treated irradiated group, there were noticeable decreases recorded in lipid contents, concentration of serum urea, creatinine and uric acid, glucose level, activity of some liver enzymes and liver and kidney TBARS levels with remarkable increases in level of HDL-C, insulin and showing elevation in GSH level and SOD and CAT activities of the liver and kidney of gamma irradiated treated rats compared to irradiated group. It was suggested that the biochemical and antioxidant amelioration observed in GFJ treated irradiated rats might be due to the antioxidant potential effects of graviola active constituents.

Automated summary

Graviola fruit juice (GFJ) has protective effects against radiation-induced oxidative stress and biochemical alterations, likely due to its antioxidant potential.