5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration

The Multifaceted Regulation of Mitochondria in Ferroptosis

(2021) Hao Wu et al.   Life-Basel

Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells

(2021) Binghua Liu et al.   Cell Death & Disease

Combination of Lutein and Zeaxanthin, and DHA Regulated Polyunsaturated Fatty Acid Oxidation in H2O2-Stressed Retinal Cells

(2020) Ho Hang Leung et al.   NEUROCHEMICAL RESEARCH

Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death

(2020) Anna Martina Battaglia et al.   Cells

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection

(2019) Alejandra Daruich et al.   Science Advances

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells

(2019) Jong-Jer Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Iron promotes oxidative cell death caused by bisretinoids of retina

(2018) Keiko Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

(2018) Kapil Chaudhary et al.   Scientific Reports

Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells

(2018) Kiyohito Totsuka et al.   EXPERIMENTAL EYE RESEARCH

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)

(2017) Tomomi Masuda et al.   Oxidative Medicine and Cellular Longevity

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

(2017) Meng-Shian Chen et al.   Oncotarget

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes

(2015) José Manuel Fernández-Real et al.   DIABETES CARE

Inhibition ofN-Methyl-d-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential

(2015) John Marshall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage

(2015) Wenjun Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

(2015) Howard Prentice et al.   Oxidative Medicine and Cellular Longevity

Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury

(2015) T Noro et al.   Cell Death & Disease

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Evaluation of the antioxidative properties of lipoxygenase inhibitors

(2014) Grzegorz A. Czapski et al.   Pharmacological Reports

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration

(2013) Y Murakami et al.   CELL DEATH AND DIFFERENTIATION

Cell signalling by reactive lipid species: new concepts and molecular mechanisms

(2012) Ashlee Higdon et al.   BIOCHEMICAL JOURNAL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Zinc–desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa

(2011) Alexey Obolensky et al.   FREE RADICAL BIOLOGY AND MEDICINE

5-Lipoxygenase: Underappreciated Role of a Pro-Inflammatory Enzyme in Tumorigenesis

(2011) Dieter Steinhilber et al.   Frontiers in Pharmacology

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

Iron Overload in Diabetic Retinopathy: A Cause or a Consequence of Impaired Mechanisms?

(2010) Andreea Ciudin et al.   Experimental Diabetes Research

Increased Expression of Glutathione Peroxidase 4 Strongly Protects Retina from Oxidative Damage

(2008) Lili Lu et al.   ANTIOXIDANTS & REDOX SIGNALING