Article
Biochemistry & Molecular Biology
Xiao Svec, Hana Storkanova, Maja Spiritovia, Krystof Slaby, Sabina Oreska, Aneta Pekacova, Barbora Hermankova, Kristyna Bubova, Petr Cesak, Haya Khouri, Gulalai Amjad, Herman Mann, Martin Komarc, Karel Pavelka, Ladislav Senolt, Josef Zamecnik, Jiri Vencovsky, Michal Tomcik
Summary: This study evaluated the impact of exercise on plasma Hsp90 levels in patients with idiopathic inflammatory myopathies (IIM) and its association with muscle damage and inflammation. The findings suggest that exercise interventions can stabilize Hsp90 levels and are correlated with changes in various inflammatory cytokines/chemokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Janusz P. Sikora, Jakub Karawani, Jaroslaw Sobczak
Summary: This study aims to determine the role of neutrophils in individual phenomena occurring during an inflammatory and anti-inflammatory reaction, considering their cidal, immunoregulatory, and reparative abilities. The study also highlights the pro- and anticoagulatory properties of endothelium in systemic inflammatory response syndrome (SIRS) and their clinical implications. Additionally, it presents clinically useful biomarkers related to neutrophils and emphasizes their role in the diagnosis and forecasting of sepsis, burn disease, and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mari Carmen Gomez-Cabrera, Aitor Carretero, Fernando Millan-Domingo, Esther Garcia-Dominguez, Angela G. Correas, Gloria Olaso-Gonzalez, Jose Vina
Summary: This review highlights the major research findings and advancements in the field of exercise redox biology, as well as discusses the biomarkers for assessing health, performance, and recovery in the sport population during exercise training. The focus is on four categories of redox biomarkers and their methodological considerations.
Review
Biochemistry & Molecular Biology
Tjasa Hertis Petek, Tadej Petek, Mirjam Mocnik, Natasa Marcun Varda
Summary: Recent studies suggest that cerebrovascular diseases and atherosclerosis originate in childhood and are influenced by chronic inflammation. Oxidative stress has been linked to cardiovascular health in adults but has not been systematically reviewed in pediatric population. The results indicate that inflammation and oxidative stress affect cardiovascular health in chronic pediatric conditions, and exercise and diet can improve oxidative status and endothelial function, although the effectiveness of antioxidant supplementation remains unclear.
Article
Biochemistry & Molecular Biology
Oscar J. Lara-Guzman, Diego A. Rivera, Vanessa Corrales-Agudelo, Laura Salazar-Jaramillo, Angel Gil-Izquierdo, Sonia Medina, Camille Oger, Thierry Durand, Jean-Marie Galano, Juan S. Escobar, Katalina Munoz-Durango, Jelver A. Sierra
Summary: Cardiometabolic disease risk factors are associated with elevated oxidative stress biomarkers. Gut microbiota dysbiosis may be linked to the intensity of oxidative metabolism. Urinary oxylipins could be specific biomarkers associated with BMI and are sensitive to be regulated by dietary antioxidants.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Xiaowan Han, Tong Li, Yang Li, Jingjing Yang, Shiqi Chen, Xiangyu Zhu, Baofu Wang, Wenkun Cheng, Lei Wang, Ziwen Lu, Xiaoxiao Wu, Yangyang Jiang, Guozhong Pan, Mingjing Zhao
Summary: This study explored the relationship between exercise and circulating microparticles (CMPs) by reviewing 26 studies. It found that untrained subjects had increased levels of CMPs after a single bout of exercise, while trained subjects had lower levels, possibly due to their better ability to adapt to changes in hemodynamics and cellular function during exercise.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Lei Gao, Qingmei Li, Hong Zhang, Min Wu, Min Fang, Lizhi Yang, Xiaojiao Li, Jingrui Liu, Cuiyun Li, Hong Chen, Xiaoxue Zhu, Yanhua Ding, Mingwei Zhou
Summary: The study confirmed pharmacokinetic biosimilarity between QX001S and ustekinumab, with high variability between subjects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Justin D. Roberts, Joseph Lillis, Jorge Marques Pinto, Ashley G. B. Willmott, Lata Gautam, Christopher Davies, Alvaro Lopez-Samanes, Juan Del Coso, Havovi Chichger
Summary: The role of natural polyphenols, particularly hydroxytyrosol, in reducing oxidative stress and supporting antioxidant mechanisms during exercise was investigated in this study using OliPhenolia (R). The results showed that OliPhenolia (R) significantly increased the bioavailability of hydroxytyrosol and demonstrated modest antioxidant effects, which may contribute to post-exercise recovery.
Article
Multidisciplinary Sciences
Tobias Neukirchen, Moritz Stork, Matthias W. Hoppe, Christian Vorstius
Summary: The study found that respiratory gases are sensitive and specific to distinguish between emotional stress and cognitive load, and can also predict cognitive performance and emotional state.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Sara Rovai, Alessandra Magini, Marco Cittar, Marco Mase, Cosimo Carriere, Mauro Contini, Carlo Vignati, Gianfranco Sinagra, Piergiuseppe Agostoni
Summary: The presence of a double threshold was identified in healthy subjects, which does not affect peak exercise performance but is associated with delayed hyperventilation induced by acidosis.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Hyun Jin Min, Kyung Soo Kim, Geun Joo Choi, Hyun Kang, Fletcher A. White
Summary: The study aimed to evaluate the concentrations of high-mobility group box 1 and heat-shock protein 70 in the upper and lower airways of healthy individuals through meta-analysis. Results showed significant heterogeneity in the concentrations of these proteins in different airway locations and age groups. Heat-shock protein 70 had significantly higher concentrations in the upper airway compared to the lower airway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Yen Chin Koay, Kelly Stanton, Vivian Kienzle, Mengbo Li, Jean Yang, David S. Celermajer, John F. O'Sullivan
Summary: This study examined the metabolic adaptation to an 80-day exercise intervention in healthy young male adults with controlled lifestyle factors. The results showed a significant shift in global metabolism, with decreases in fatty acids and ketone bodies in response to increased aerobic fitness. A variety of metabolic substrates experienced significant changes, indicating the extensive impact of exercise on metabolism.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chantalle Moulton, Elisa Grazioli, Cristina Antinozzi, Cristina Fantini, Claudia Cerulli, Arianna Murri, Guglielmo Duranti, Roberta Ceci, Maria Chiara Vulpiani, Patrizia Pellegrini, Sveva Maria Nusca, Francesco Cavaliere, Simona Fabbri, Paolo Sgro, Luigi Di Luigi, Daniela Caporossi, Attilio Parisi, Ivan Dimauro
Summary: Exercise has positive effects on post-surgery breast cancer patients undergoing adjuvant therapy, maintaining redox homeostasis, improving physical fitness and mental well-being.
Article
Sport Sciences
Francesca Anselmi, Luna Cavigli, Antonio Pagliaro, Serafina Valente, Francesca Valentini, Matteo Cameli, Marta Focardi, Nicola Mochi, Paul Dendale, Dominique Hansen, Marco Bonifazi, Martin Halle, Flavio D'Ascenzi
Summary: The study found that the recommended exercise intensity definition based on percentages of peak HR and peak VO2 may misclassify the effective exercise intensity. Using a ventilatory threshold-based approach may be more suitable for defining an appropriate level of exercise intensity, especially in cardiac patients.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Rheumatology
Sarah L. Patterson, Shenghuan Sun, Dmitry Rychkov, Patricia Katz, Alexandra Tsitsiklis, Mary C. Nakamura, Paula Hayakawa Serpa, Charles R. Langelier, Marina Sirota
Summary: This study found that physical activity is closely associated with the expression of inflammatory genes and signaling pathways in patients with rheumatoid arthritis (RA). After adjusting for sex, age, race, and ethnicity, the most physically active patients showed downregulation of several immune signaling pathways implicated in RA pathogenesis. These results suggest that physical activity may have a protective effect in RA.
JOURNAL OF RHEUMATOLOGY
(2022)