Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Zimo Zhao, Xinyi He, Yan Sun
Summary: A meta-analysis found that the use of sulfonylureas and insulin in diabetic patients may increase the incidence of pancreatic cancer, while metformin and TZDs were not significantly associated with pancreatic cancer incidence. Due to significant heterogeneity across studies, further well-adjusted data and better-organized clinical trials are needed to interpret the relationship between hypoglycemic agents and pancreatic cancer incidence in diabetic patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Kim, Hye Soon Kim, Il Seong Nam-Goong, Eun Sook Kim, Jin Ook Chung, Dong-Hyeok Cho, Chang Won Lee, Young Il Kim, Dong Jin Chung, Kyu Chang Won, In Joo Kim, Tae Sun Park, Duk Kyu Kim, Hosang Shon
Summary: The quadruple oral hypoglycemic agent regimen has shown therapeutic efficacy in type 2 diabetes mellitus patients who cannot use insulin or reject injectable therapy. This treatment significantly reduces HbA1c levels, improves lipid profiles and liver enzyme levels, without causing significant safety issues.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Food Science & Technology
Chong Ning, Yuhan Jiao, Jiaqi Wang, Weiwei Li, Jingqiu Zhou, Yi-Chieh Lee, Dik-Lung Ma, Chung-Hang Leung, Rugang Zhu, Hui-Min David Wang
Summary: Diabetes is a global concern, with type 2 diabetes accounting for the majority of cases. Diet plays a crucial role in the development and control of diabetes. Natural substances may hold the key to diabetic health products and preventive treatments.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Medicine, Research & Experimental
Butian Wei, Xin Zhang, Jiwei Qian, Zhe Tang, Bo Zhang
Summary: Nrf2 is an important intracellular regulator of antioxidant stress, regulating not only antioxidant function but also insulin secretion, proliferation, and differentiation of beta cells, ER stress, and mitochondrial function. Pharmacological activation of Nrf2 has been shown to protect islet cells during different stages of transplantation in experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Murugan Prasathkumar, Robert Becky, Salim Anisha, Chenthamara Dhrisya, Subramaniam Sadhasivam
Summary: This review summarizes the current management principles of type 2 diabetes, including oral hypoglycemic agents, types of insulin administration, diet maintenance, and various molecular approaches. These treatments play significant roles in glycemic control and management of T2DM.
BIOTECHNOLOGY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Tatsuya Maruhashi, Yukihito Higashi
Summary: Endothelial dysfunction is crucial in the progression of atherosclerosis and is significantly associated with diabetes mellitus and oxidative stress. Selecting appropriate therapeutic interventions that improve endothelial function is important for preventing diabetic vascular complications. Various hypoglycemic drugs and agents like GLP-1 receptor agonists and SGLT2 inhibitors may improve endothelial function through multiple mechanisms independent of glucose control or insulin signaling.
Review
Biochemistry & Molecular Biology
Anju Singh, Ritushree Kukreti, Luciano Saso, Shrikant Kukreti
Summary: Oxidative stress is a metabolic dysfunction caused by the imbalance between reactive oxygen species production and the body's antioxidant defense system. It is closely related to the development of various noncommunicable diseases. Diabetes mellitus, especially type 2 diabetes, is significantly influenced by oxidative stress, which plays a crucial role in insulin signaling pathways.
Article
Plant Sciences
Feng Zhang, Dan Chen, Liming Zhang, Qingyujing Zhao, Yage Ma, Xi Zhang, Shenglan Zhao, Chaoyin Chen
Summary: The study found that diaphragma juglandis extract could improve metabolic abnormalities in type 2 diabetic rats, including insulin resistance, abnormal lipid metabolism, liver damage, oxidative stress, and reduce inflammation. It also prevented the pathological damage of pancreas and liver, and intercepted the disorders of gut microbes.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kendal Erdem Duman, Abdulahad Dogan, Burak Kaptaner
Summary: In this study, the ameliorative role of Cyanus depressus plant ethanolic extract in streptozotocin-induced liver, kidney, and pancreas damage in rats was assessed. The results showed that CD administration reduced hyperglycemia, oxidative stress, and histopathology, while improving antioxidant defenses.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
Lu Zhang, Xin Qi, Xin-tong Lu, Cheng-bi Cui, Xue-feng Gao
Summary: This study explored the effects of different radiation doses on the hypoglycemic effects of the Co-60-gamma irradiated ginseng adventitious root extract. The irradiation increased the saponin content and radical scavenging ability of the extract. The irradiated extract showed superior protection on glomerular mesangial cells and significantly reduced glucose levels in mice with type 1 diabetes, possibly through the activation of the Keap1/Nrf2/HO-1 pathway and attenuation of oxidative stress.
Review
Biochemistry & Molecular Biology
Meiming Su, Wenqi Zhao, Suowen Xu, Jianping Weng
Summary: Diabetes mellitus (DM) is a common chronic disease with significant complications. Resveratrol, a plant-derived compound, has shown protective effects against diabetes and its cardiovascular complications. These effects are mediated through various signaling pathways.
Review
Endocrinology & Metabolism
Chrysoula Boutari, Panagiotis D. Pappas, Theodoros D. Theodoridis, Dimitrios Vavilis
Summary: This article reviews the role of Humanin (HN) in insulin resistance and diabetes treatment, as well as its potential application in age-related diseases such as Alzheimer's disease.
WORLD JOURNAL OF DIABETES
(2022)
Article
Biochemistry & Molecular Biology
Dan Shen, Yingjian Lu, Shuhua Tian, Shaotong Ma, Jing Sun, Qiaobin Hu, Xinyi Pang, Xiangfei Li
Summary: The study showed that L-arabinose can improve symptoms of diabetes mellitus in a mouse model of T2DM, including lowering blood glucose, alleviating steatosis, and repairing pancreatic islet cells. Furthermore, it was found to have a regulatory effect on gut microbiota.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Hematology
Jie Lin, Qian Ren, Fanjie Zhang, Jing Gui, Xin Xiang, Qin Wan
Summary: This study investigated the role and mechanism of beta-hydroxybutyrate dehydrogenase 1 (Bdh1) in regulating macrophage oxidative stress in diabetes-induced atherosclerosis (AS). The results showed that Bdh1 expression was decreased in patients with diabetes-induced AS, HG-treated macrophages, and diabetic Apoe(-/-) mice. AAV-mediated Bdh1 overexpression attenuated aortic plaque formation in diabetic Apoe(-/-) mice, while silencing of Bdh1 increased reactive oxygen species (ROS) production and an inflammatory response in macrophages.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Emergency Medicine
Emine Kadioglu, Yasemin Teksen, Cengiz Kocak, Fatma Emel Kocak
Summary: The study showed that bardoxolone methyl (BM) prevented the progression of crush-related acute kidney injury in rats possibly through its cytoprotective effects, which include antioxidant, anti-inflammatory and anti-apoptotic properties.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2021)
Article
Medicine, General & Internal
Hertzel C. Gerstein, Naveed Sattar, Julio Rosenstock, Chinthanie Ramasundarahettige, Richard Pratley, Renato D. Lopes, Carolyn S. P. Lam, Nardev S. Khurmi, Laura Heenan, Stefano Del Prato, Leanne Dyal, Kelley Branch
Summary: The trial compared the cardiovascular and renal outcomes of weekly injections of efpeglenatide versus a placebo in participants with type 2 diabetes and a history of cardiovascular disease or current kidney disease. The study found that the risk of cardiovascular events was lower with efpeglenatide treatment, and a composite renal outcome event was also reduced.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Bunyamin Aydin, Serhat Ozcelik, Turkan Pasali Kilit, Sertac Eraslan, Mehmet Celik, Kevser Onbasi
Summary: This study investigated the effect of iron deficiency anemia (IDA) on glycosylated hemoglobin (HbA1c) levels. The results demonstrated a correlation between IDA and increased HbA1c concentrations, which significantly decreased after iron treatment. Therefore, IDA should be considered when making decisions based on HbA1c for diagnosis or treatment.
PRIMARY CARE DIABETES
(2022)
Article
Medicine, General & Internal
Mustafa Yontem, Serap Arslan, Behic Selman Erdogdu, Fatma Emel Kocak
Summary: This study compared serum levels of oxidative stress markers in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) with healthy controls in Kutahya city, Turkey. The results showed higher TOS and OSI levels in SH and OH groups compared to healthy controls, while lower levels of TAS, PON-1, and ARYL were observed in SH and OH groups.
GOMAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Ertac Berker, Turkan Pasali Kilit, Filiz Ozyigit
Summary: This study analyzed the drug use of geriatric patients in Turkey using the American 2019 Beers criteria and the Turkish Inappropriate Medication Use in the Elderly (TIME) criteria. The findings showed that the TIME criteria were more successful in evaluating potentially inappropriate medications (PIMs) among the elderly in Turkey, and PIMs were significantly higher in polypharmacy patients.
TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI
(2022)
Article
Endocrinology & Metabolism
Turkan Pasali Kilit, Kevser Onbasi, Filiz Ozyigit
Summary: This study evaluated osteoporosis awareness and risk in individuals, finding that the majority of participants had a low risk of osteoporosis. The Osteoporosis Self-Assessment Tool for Asians was more effective in determining the risk level compared to the One-Minute Osteoporosis Risk Test. Men should be given equal importance as women in terms of osteoporosis education and media tools should be used more effectively for this purpose.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Article
Biochemistry & Molecular Biology
Gulsum Abusoglu, Cengiz Kocak, Fatma Emel Kocak, Bahadir Ozturk, Husamettin Vatansev
Summary: This study compared the cytotoxic effects of tamoxifen and docetaxel with the antiproliferative effects of ukrain on breast cancer cells. The results showed no significant difference between ukrain and docetaxel in terms of proapoptotic and antiapoptotic protein expression in both cell lines. While tamoxifen was more effective than ukrain in MCF-7 cells, ukrain was more effective than tamoxifen in MDA MB-231 cells for inducing apoptosis. These findings suggest that ukrain may be a useful therapeutic agent for treating receptor-negative breast cancer cells.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Article
Biochemistry & Molecular Biology
Fatma Emel Kocak, Raziye Akcilar, Fatih Kar, Ozben Ozden Isiklar, Sahinde Atlanoglu, Ozlem Genc, Fatima Yaman
Summary: This study found that genetic polymorphism in the ACE gene may be associated with lung injury in COVID-19 patients. The DD genotype and D allele increase the risk of lung injury, while the I allele has a protective effect.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Article
Medicine, General & Internal
Turkan Pasali Kilit, Filiz Ozyigit, Sertas Erarslan, Kevser Onbasi
Summary: Clinically important potential drug-drug interactions (pDDIs) are common in COVID-19 patients and require close monitoring. Patients should be observed for possible clinical manifestations such as QT prolongation, hypoglycemia, and hemorrhage during treatment. Polypharmacy in COVID-19 patients should also be carefully managed.
AFRICAN HEALTH SCIENCES
(2022)
Article
Medicine, General & Internal
Turkan Pasali Kilit, Filiz Ozyigit, Kevser Onbasi
Summary: Despite low treatment adherence among most patients with hypothyroidism, the proportion of patients with TSH levels in the normal range is high. Low education level, low socioeconomic status, comorbidities, and multiple drug use are associated with low treatment adherence.
Article
Rehabilitation
Ismail Okur, Betul Taspinar, Turkan P. Kilit, Eda O. Okur, Ferruh Taspinar
Summary: The study found that patients with T2DM are more likely to have musculoskeletal system disorders and higher levels of kinesiophobia compared to non-diabetic individuals.
AUSTRALIAN JOURNAL OF REHABILITATION COUNSELLING
(2021)
Article
Medicine, General & Internal
Behic Selman Erdogdu, Mustafa Yontem, Fatma Emel Kocak, Hayrullah Yazar
Summary: The study revealed that postmenopausal women have higher levels of oxidative stress parameters and lower levels of antioxidant defense, which may lead to the occurrence of diseases such as cardiovascular disorders.
GOMAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Ayse Nur Deger, Filiz Ozyigit, Fatma Emel Kocak, Zulfu Bayhan, Sezgin Zeren, Ozlem Arik, Hakki Deger
Summary: This study demonstrated the corrective effect of verbascoside on histomorphological and biochemical differences induced by colon ischemia-reperfusion (I/R) injury in rats. Verbascoside increased goblet cell number, promoted cell proliferation, and decreased apoptosis. Additionally, it led to an increase in antioxidant enzyme levels and a decrease in oxidative stress markers.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2021)