A novel approach to treating opioid use disorders: Dual agonists of glucagon-like peptide-1 receptors and neuropeptide Y2 receptors

The design of a GLP‐1/PYY dual acting agonist

(2021) Soren Ostergaard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis

(2021) Brandon T. Milliken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

(2021) Melanie Davies et al.   LANCET

Once-Weekly Semaglutide in Adults with Overweight or Obesity

(2021) John P.H. Wilding et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel dual agonist of glucagon-like peptide-1 receptors and neuropeptide Y2 receptors attenuates fentanyl taking and seeking in male rats

(2021) Yafang Zhang et al.   NEUROPHARMACOLOGY

A novel mouse model of glucagon‐like peptide‐1 receptor expression: a look at the brain

(2020) Devon L. Graham et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent

(2020) Mathias E. Jensen et al.   NEUROCHEMISTRY INTERNATIONAL

Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease

(2020) Laurie L. Baggio et al.   Molecular Metabolism

Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats

(2020) Joaquin E. Douton et al.   BEHAVIOURAL PHARMACOLOGY

The economic burden of opioid use disorder and fatal opioid overdose in the United States, 2017

(2020) Curtis Florence et al.   DRUG AND ALCOHOL DEPENDENCE

Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Suppress Voluntary Alcohol Intake in Male Wistar Rats

(2020) Vincent N. Marty et al.   Frontiers in Neuroscience

Astrocytes as cellular mediators of cue reactivity in addiction

(2020) Anna Kruyer et al.   CURRENT OPINION IN PHARMACOLOGY

Central GLP-1 receptors: Novel molecular targets for cocaine use disorder

(2019) N.S. Hernandez et al.   PHYSIOLOGY & BEHAVIOR

Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats

(2019) E. Andrew Townsend et al.   NEUROPSYCHOPHARMACOLOGY

Regulation of Memory Function by Feeding-Relevant Biological Systems: Following the Breadcrumbs to the Hippocampus

(2019) Andrea N. Suarez et al.   Frontiers in Molecular Neuroscience

Heroin Cue-Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking

(2019) Anna Kruyer et al.   BIOLOGICAL PSYCHIATRY

Activation of GLP-1 receptors attenuates oxycodone taking and seeking without compromising the antinociceptive effects of oxycodone in rats

(2019) Yafang Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Glucagon-like peptide-1 receptor activation in the ventral tegmental area attenuates cocaine seeking in rats

(2018) Nicole S. Hernandez et al.   NEUROPSYCHOPHARMACOLOGY

Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors

(2018) Oleg G. Chepurny et al.   Scientific Reports

Relapse to opioid seeking in rat models: behavior, pharmacology and circuits

(2018) David J. Reiner et al.   NEUROPSYCHOPHARMACOLOGY

Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment

(2018) Sandra D. Comer et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Gut-brain axis and addictive disorders: A review with focus on alcohol and drugs of abuse

(2018) Elisabet Jerlhag   PHARMACOLOGY & THERAPEUTICS

PYY(3-36) and exendin-4 reduce food intake and activate neuronal circuits in a synergistic manner in mice

(2018) Marina Kjaergaard et al.   NEUROPEPTIDES

GLP-1 acts on habenular avoidance circuits to control nicotine intake

(2017) Luis M Tuesta et al.   NATURE NEUROSCIENCE

Opioid-induced rewards, locomotion, and dopamine activation: A proposed model for control by mesopontine and rostromedial tegmental neurons

(2017) Stephan Steidl et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Central GLP-1 receptor activation modulates cocaine-evoked phasic dopamine signaling in the nucleus accumbens core

(2017) Samantha M. Fortin et al.   PHYSIOLOGY & BEHAVIOR

Hindbrain DPP-IV inhibition improves glycemic control and promotes negative energy balance

(2017) Elizabeth G. Mietlicki-Baase et al.   PHYSIOLOGY & BEHAVIOR

Reasons for discontinuation of GLP1 receptor agonists: data from a real-world cross-sectional survey of physicians and their patients with type 2 diabetes

(2017) Mirko Sikirica et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

In vivo and in vitro degradation of peptide YY3–36 to inactive peptide YY3–34 in humans

(2016) Signe Toräng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The complexity of signalling mediated by the glucagon-like peptide-1 receptor

(2016) Madeleine M. Fletcher et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A systematic analysis of published clinical trials

(2016) Karolin Bettge et al.   DIABETES OBESITY & METABOLISM

Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance

(2016) D. J. Reiner et al.   JOURNAL OF NEUROSCIENCE

Reversal of morphine-induced cell-type–specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement

(2016) Matthew C. Hearing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex and estrogens alter the action of glucagon-like peptide-1 on reward

(2016) Jennifer E. Richard et al.   Biology of Sex Differences

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

(2015) Michael D. Scofield et al.   BIOLOGICAL PSYCHIATRY

Glucagon-Like Peptide-1 Receptor Activation in the Ventral Tegmental Area Decreases the Reinforcing Efficacy of Cocaine

(2015) Heath D Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice

(2015) Gunnar Sørensen et al.   PHYSIOLOGY & BEHAVIOR

Role of projections from ventral subiculum to nucleus accumbens shell in context-induced reinstatement of heroin seeking in rats

(2015) Jennifer M. Bossert et al.   PSYCHOPHARMACOLOGY

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

(2015) Simon C. Cork et al.   Molecular Metabolism

Effects of PYY3–36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men

(2014) Julie Berg Schmidt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia

(2014) Hui Fan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery

(2014) Caitlin M. Vander Weele et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal GLP1R mediates liraglutide’s anorectic but not glucose-lowering effect

(2014) Stephanie Sisley et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity

(2014) N. Gong et al.   JOURNAL OF NEUROSCIENCE

The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors

(2013) Elizabeth G. Mietlicki-Baase et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt

(2013) Laura E. Rupprecht et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons

(2013) Alex S. James et al.   BEHAVIOURAL BRAIN RESEARCH

Ligands of the neuropeptide Y Y2 receptor

(2013) Gopi Kumar Mittapalli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Y2 receptor agonist PYY3–36 increases the behavioural response to novelty and acute dopaminergic drug challenge in mice

(2013) Ulrike Stadlbauer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

An Overview of Animal Models of Pain: Disease Models and Outcome Measures

(2013) Nicholas S. Gregory et al.   JOURNAL OF PAIN

Real-time trafficking and signaling of the glucagon-like peptide-1 receptor

(2013) Sarah Noerklit Roed et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Gut Peptide GLP-1 and Its Analogue, Exendin-4, Decrease Alcohol Intake and Reward

(2013) Rozita H. Shirazi et al.   PLoS One

The Glucagon-Like Peptide 1 Analogue, Exendin-4, Attenuates the Rewarding Properties of Psychostimulant Drugs in Mice

(2013) Emil Egecioglu et al.   PLoS One

Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance

(2013) Keval Chandarana et al.   Molecular Metabolism

Hindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance

(2012) Harvey J. Grill et al.   Cell Metabolism

Possible Mechanisms of Circulating PYY-Induced Satiation in Male Rats

(2012) Ulrike Stadlbauer et al.   ENDOCRINOLOGY

Glucagon-like peptide-1 in the rat brain: Distribution of expression and functional implication

(2012) Guibao Gu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

(2012) Kevin W Williams et al.   NATURE NEUROSCIENCE

Distinct roles for direct and indirect pathway striatal neurons in reinforcement

(2012) Alexxai V Kravitz et al.   NATURE NEUROSCIENCE

Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively

(2012) T. Enoksson et al.   NEUROPHARMACOLOGY

Interspecies Modeling and Prediction of Human Exenatide Pharmacokinetics

(2012) Ting Chen et al.   PHARMACEUTICAL RESEARCH

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

The Gut Hormones PYY3-36 and GLP-17-36 amide Reduce Food Intake and Modulate Brain Activity in Appetite Centers in Humans

(2011) Akila De Silva et al.   Cell Metabolism

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

(2011) Scott E. Kanoski et al.   ENDOCRINOLOGY

GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

(2011) Amber L. Alhadeff et al.   ENDOCRINOLOGY

Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass

(2011) W K Fenske et al.   INTERNATIONAL JOURNAL OF OBESITY

Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function

(2011) J. G. Barrera et al.   JOURNAL OF NEUROSCIENCE

Glucagon-Like Peptide 1 Receptors in Nucleus Accumbens Affect Food Intake

(2011) A. M. Dossat et al.   JOURNAL OF NEUROSCIENCE

The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide

(2011) Scott E. Kanoski et al.   NEUROPHARMACOLOGY

Comparative Effects of the Long-Acting GLP-1 Receptor Ligands, Liraglutide and Exendin-4, on Food Intake and Body Weight Suppression in Rats

(2011) Matthew R. Hayes et al.   Obesity

Neuronal circuits underlying acute morphine action on dopamine neurons

(2011) M. Jalabert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide YY

(2011) Keval Chandarana et al.   Current Opinion in Endocrinology Diabetes and Obesity

The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons

(2011) Mary Kay Lobo et al.   Frontiers in Neuroanatomy

Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure

(2010) Linda Rinaman   BRAIN RESEARCH

Peptide hormones regulating appetite-focus on neuroimaging studies in humans

(2010) Haiko Schloegl et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial

(2010) Richard M Bergenstal et al.   LANCET

Effects of Exendin-4 Alone and With Peptide YY3–36 on Food Intake and Body Weight in Diet-Induced Obese Rats

(2010) Roger D. Reidelberger et al.   Obesity

Role of the glucagon-like-peptide-1 receptor in the control of energy balance

(2010) Matthew R. Hayes et al.   PHYSIOLOGY & BEHAVIOR

Incretin-based therapies for type 2 diabetes mellitus

(2009) Julie A. Lovshin et al.   Nature Reviews Endocrinology

Intrameal Hepatic Portal and Intraperitoneal Infusions of Glucagon-Like Peptide-1 Reduce Spontaneous Meal Size in the Rat via Different Mechanisms

(2008) Elisabeth B. Rüttimann et al.   ENDOCRINOLOGY

Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking

(2008) R. T. LaLumiere et al.   JOURNAL OF NEUROSCIENCE

The role of peptide YY in appetite regulation and obesity

(2008) Efthimia Karra et al.   JOURNAL OF PHYSIOLOGY-LONDON

PYY(3–36) induces Fos in the arcuate nucleus and in both catecholaminergic and non-catecholaminergic neurons in the nucleus tractus solitarius of rats

(2007) J.E. Blevins et al.   PEPTIDES