Article
Gastroenterology & Hepatology
Joana Torres, Ryan C. Ungaro, Jean-Frederic Colombel
Summary: Inflammatory bowel disease has a preclinical phase with altered immune and inflammatory pathways, which offers opportunities for disease prediction and prevention.
Article
Gastroenterology & Hepatology
Abigail Raffner Basson, Jeffry Katz, Sargun Singh, Fabiano Celio, Fabio Cominelli, Alexander Rodriguez-Palacios
Summary: Although artificial sweeteners are considered safe, they can contribute to gastrointestinal inflammation. In this study, IBD patients were found to consume artificial sweeteners and low calorie foods/drinks more frequently compared to control participants. Consumption of artificial sweeteners correlated with healthy habits among IBD patients.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pediatrics
Brad D. Constant, Edwin F. de Zoeten, Marisa G. Stahl, Ravy K. Vajravelu, James D. Lewis, Blair Fennimore, Mark E. Gerich, Frank Scott
Summary: Prior authorizations are associated with prolonged biologic initiation time and increased IBD-related healthcare utilization.
Review
Pharmacology & Pharmacy
Thomas K. Wiersma, Marijn C. Visschedijk, Nanne K. de Boer, Marjolijn N. Lub-de Hooge, Jelmer R. Prins, Daan J. Touw, Paola Mian
Summary: This systematic review examined the impact of pregnancy and inflammatory bowel disease (IBD) on the pharmacokinetics (PK) of drugs used for IBD. Limited studies have been conducted on the PK parameters during pregnancy for these drugs, highlighting the need for more extensive research to determine PK values and develop evidence-based dosing regimens.
Article
Cell Biology
Lili Ye, Yongwei Lin, Xing-di Fan, Yaoming Chen, Zengli Deng, Qian Yang, Xiaotian Lei, Jizong Mao, Chunhui Cui
Summary: The number of patients with Inflammatory bowel disease (IBD) is increasing globally. Researchers identified IBD-related genes using a SVM-based method based on disease similarities and gene interactions, achieving good results. The study highlights the importance of genetic factors in the occurrence of IBD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Peter von Philipsborn, Oliver Huizinga, Anna Leibinger, Diana Rubin, Jacob Burns, Karl Emmert-Fees, Sara Pedron, Michael Laxy, Eva Rehfuess
Summary: Germany's national strategy for sugar reduction in soft drinks based on voluntary commitments by industry since 2015 has not achieved the desired results. The mean sales-weighted sugar content of soft drinks in Germany only decreased by 2% between 2015-2021, falling short of the stated targets and the reduction observed in the United Kingdom. While sugar sales from soft drinks in Germany decreased slightly, they still remain high from a public health perspective. Additional policy measures may be necessary to support further sugar reduction in soft drinks in Germany.
ANNALS OF NUTRITION AND METABOLISM
(2023)
Article
Infectious Diseases
Thirumalaisamy P. Velavan, Srinivas Reddy Pallerla, Peter G. Kremsner
Summary: COVID-19 antigen testing is widely used in the EU, but self-testing may be influenced by other factors. Research found that certain beverages can cause false-positive test results. Therefore, attention should be paid to the accuracy of testing methods to avoid incorrect results.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Biology
Federica Furfaro, Arianna Dal Buono, Mariangela Allocca, Ferdinando D'Amico, Alessandra Zilli, Roberto Gabbiadini, Silvio Danese
Summary: Bowel ultrasound (BUS) is a non-invasive and accurate technique for assessing activity, extension of disease, and complications in inflammatory bowel diseases. It provides a safe and cost-effective alternative to colonoscopy and magnetic resonance, with high sensitivity and specificity compared to endoscopy. BUS allows for quick diagnosis and treatment decisions by distinguishing between inflammation and fibrosis.
Review
Medicine, General & Internal
Carla J. Gargallo-Puyuelo, Viviana Laredo, Fernando Gomollon
Summary: Thiopurines play a crucial role in the treatment of IBD, but there are still unresolved issues regarding their efficacy and safety. Personalized therapy based on pharmacogenomics and genetic polymorphisms of metabolizing enzymes may help prevent side effects. Factors such as age, ethnicity, and viral infections also influence the outcomes of thiopurine therapy.
FRONTIERS IN MEDICINE
(2021)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Medicine, General & Internal
Viviana Laredo, Carla J. Gargallo-Puyuelo, Fernando Gomollon
Summary: The availability of biologics for inflammatory bowel disease (IBD) treatment has increased significantly, providing more options for patients. However, choosing the right biologic therapy can be challenging, especially for bio-naive patients. Evidence from clinical trials comparing biologics with placebo is limited, and network meta-analysis and real-world studies have been developed to address this issue. In addition to these studies, other important factors to consider when choosing a biologic therapy include patient preferences, comorbidities, genetics, and inflammatory markers. The cost of biologic therapy is also an important consideration, with biosimilars offering a cost-effective alternative. This review summarizes the evidence comparing biologic therapies for both Crohn's disease (CD) and ulcerative colitis (UC) in different clinical situations, while also discussing predictors of biologic response, the use of biologics in extraintestinal manifestations, and the significance of drug-related costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Xin Jiao, Wen-yu Wu, Shao-feng Zhan, Jian-bo Liu, Xian-jin Zhang
Summary: This study found a bidirectional causal relationship between inflammatory bowel disease, Crohn's disease, and sarcopenia. However, no such relationship was found in ulcerative colitis. Additionally, genetically predicted usual walking pace may reduce the risk of Crohn's disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ryan W. Stidham, Kento Takenaka
Summary: Artificial intelligence (AI) has the potential to greatly impact the assessment, monitoring, and management of inflammatory bowel disease (IBD). The use of machine learning methods in AI has shown remarkable results in replicating expert judgment and predicting clinical outcomes. AI applications in IBD include endoscopic image interpretation and scoring, cross-sectional image analysis, natural language processing for clinical text understanding, and AI-powered clinical decision support tools. AI has the potential to advance concepts of disease activity assessment, care pathways, and pathophysiologic mechanisms in IBD.
Review
Gastroenterology & Hepatology
Maaser Christian, Maconi Giovanni, Kucharzik Torsten, Allocca Mariangela
Summary: Intestinal ultrasound is a non-invasive and accurate tool for assessing inflammatory bowel disease. It has the potential to change the way treatment response is evaluated and speed up the clinical decision-making process. Development of validated sonographic scores and spreading knowledge of intestinal ultrasound remain important issues for the future.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Leonardo Da Rio, Marco Spadaccini, Tommaso Lorenzo Parigi, Roberto Gabbiadini, Arianna Dal Buono, Anita Busacca, Roberta Maselli, Alessandro Fugazza, Matteo Colombo, Silvia Carrara, Gianluca Franchellucci, Ludovico Alfarone, Antonio Facciorusso, Cesare Hassan, Alessandro Repici, Alessandro Armuzzi
Summary: Inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, pose a growing burden on healthcare systems worldwide. Artificial intelligence has emerged as an essential tool in the diagnosis, treatment, and surveillance of these diseases, as well as in data collection and analysis. This review discusses the recent evidence and potential future developments in the use of artificial intelligence in inflammatory bowel diseases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
