期刊
NEUROPEPTIDES
卷 91, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.npep.2021.102213
关键词
Neuroendocrine system; Neuroactive factors; Immune system; Maternal fetal immunity; Reproductive immunity
资金
- Shanghai Science and Technology Committee [19411960300]
- Shanghai Hospital Development Center [SHDC12019113]
This review focuses on the role of neuroactive factors in pregnancy, particularly their modulation of the immune system and lymphocytes.
Pregnancy, from insemination to parturition, is a highly complex but well-orchestrated process that requires various organs and systems to participate. Immune system and neuroendocrine system are important regulators in healthy pregnancy. Dozens of neuroactive factors have been detected in human placenta, whether they are locally secreted or circulated. Among them, some are vividly studied such as corticotropin-releasing hormone (CRH), human chorionic gonadotropin (hCG), transforming growth factor-13 (TGF-13), progesterone and estrogens, while others are relatively lack of research. Though the neuroendocrine-immune interactions are demonstrated in some diseases for decades, the roles of neuroactive factors in immune system and lymphocytes during pregnancy are not fully elucidated. This review aims to provide an interdisciplinary view on how the neuroendocrine system mediate immune system during pregnancy process.
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