Article
Gastroenterology & Hepatology
Neeraj Narula, Emily C. L. Wong, John K. Marshall, Jean-Frederic Colombel, Parambir S. Dulai, Walter Reinisch
Summary: For patients with moderate to severe biologic naive UC, infliximab and vedolizumab have similar efficacy in improving clinical symptoms, but infliximab has higher rates of corticosteroid-free clinical remission (CR) and endoscopic remission (ER) after 1 year of treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose M. Huguet, Victor Garcia-Lorenzo, Lidia Marti, Jose Maria Paredes, Jose Joaquin Ramirez, Miguel Pastor, Lucia Ruiz, Ana Sanahuja, Pilar Timoneda, Laura Sanchis, Gloria Alemany Perez, Marta Maia Bosca-Watts
Summary: This study evaluated the efficacy and safety of subcutaneous infliximab in patients with inflammatory bowel disease. The results showed that subcutaneous administration of infliximab has the potential to maintain treatment stability and increase drug levels. This is of great significance for the management of patients with inflammatory bowel disease.
Review
Gastroenterology & Hepatology
Cindy C. Y. Law, Bryce Tkachuk, Stephen Lieto, Neeraj Narula, Samantha Walsh, Jean-Frederic Colombel, Ryan C. Ungaro
Summary: Early biologic treatment is associated with lower rates of surgery in patients with Crohn's disease, while it appears to be associated with higher rates of colectomy in patients with ulcerative colitis, which may be confounded by disease severity.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Pharmacology & Pharmacy
Alix Demaris, Ella S. K. Widigson, Johan F. K. F. Ilvemark, Casper Steenholdt, Jakob B. Seidelin, Wilhelm Huisinga, Robin Michelet, Linda B. S. Aulin, Charlotte Kloft
Summary: This review aims to analyze the population PK models of infliximab (IFX) in patients with ulcerative colitis (UC) and acute severe UC (ASUC), and assess the impact of disease activity on IFX PK. The results showed that there are still many gaps in the current research, such as a limited number of models specifically developed for UC patients, a lack of studies on severe UC patients, and a lack of evaluation of predictive performance for the models. Therefore, more comprehensive research and adequate reporting and evaluation of the models are needed for clinical application.
Article
Medicine, General & Internal
Theresa Hunter, Wendy J. Komocsar, Richard B. Colletti, Chunyan Liu, Keith J. Benkov, Jennifer L. Dotson, Steven J. Steiner, Nanhua Zhang, Wallace Crandall, ImproveCareNow Network
Summary: This study aimed to assess treatment patterns and dosing of biologics over 3 years in pediatric patients with UC or CD. The use of corticosteroids was common at the initial visit. Anti-TNFs were the most commonly used class of biologics, but the reported doses were higher than the standard guidelines.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Gastroenterology & Hepatology
Emily C. L. Wong, Shahin Merat, Cristina Monaco, Parambir S. Dulai, Vipul Jairath, John K. Marshall, Walter Reinisch, Neeraj Narula
Summary: In this post-hoc analysis, infliximab showed superior efficacy over tofacitinib for the treatment of moderate to severe biologic-naive UC. However, baseline characteristic mismatches persisted despite propensity score matching, and further studies are needed to confirm these findings.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Miikka Hoyhtya, Katri Korpela, Schahzad Saqib, Sofia Junkkari, Eija Nissila, Anne Nikkonen, Evgenia Dikareva, Anne Salonen, Willem M. de Vos, Kaija-Leena Kolho
Summary: This study aimed to investigate the absolute abundances of gut microbiota in relation to the response to induction therapy with infliximab in pediatric inflammatory bowel disease. The results showed that the treatment responsive group had a higher absolute abundance of Bifidobacteriales and a lower absolute abundance of Actinomycetales compared to the nonresponders. However, the level of inflammation according to fecal calprotectin showed no statistically significant association with the absolute abundances of fecal microbiota. The results on relative abundances differed from the absolute abundances.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Emily C. L. Wong, Parambir S. Dulai, John K. Marshall, Vipul Jairath, Walter Reinisch, Neeraj Narula
Summary: In this post hoc analysis, treatment with infliximab and ustekinumab achieved 1-year clinical remission with similar efficacy among biologic-naive Crohn's disease patients who responded to induction therapy. However, infliximab may confer greater benefit for endoscopic outcomes.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Multidisciplinary Sciences
Renato Sablich, Maria Teresa Urbano, Marco Scarpa, Federico Scognamiglio, Alberto Paviotti, Edoardo Savarino
Summary: In this retrospective study, VDZ was found to be superior to IFX in terms of clinical remission, drug persistency, clinical response, and steroid-free remission for the treatment of moderate-to-severe ulcerative colitis. However, VDZ group required more drug optimization compared to the IFX group.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Camilla de Almeida Martins, Matheus Freitas Cardoso de Azevedo, Alexandre Sousa Carlos, Aderson Omar Mourao Cintra Damiao, Carlos Walter Sobrado Jr, Sergio Carlos Nahas, Natalia Sousa Freitas Queiroz
Summary: This study has enhanced our understanding of the predictive factors of treatment response to IFX in a well-characterized Brazilian IBD population. The study found that the duration of IFX therapy and higher albumin levels increased the likelihood of clinical remission, while previous surgery decreased its chance. Prior use of adalimumab and higher C-reactive protein levels reduced the likelihood of endoscopic remission.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Stefan Schreiber, Shomron Ben-Horin, Jaroslaw Leszczyszyn, Robert Dudkowiak, Adi Lahat, Beata Gawdis-Wojnarska, Aldis Pukitis, Marek Horynski, Katalin Farkas, Jaroslaw Kierkus, Maciej Kowalski, Sang Joon Lee, Sung Hyun Kim, Jee Hye Suh, Mi Rim Kim, Seul Gi Lee, Byong Duk Ye, Walter Reinisch
Summary: This study demonstrated the pharmacokinetic noninferiority of CT-P13 SC to CT-P13 IV, with comparable clinical remission rates between the two formulations.
Article
Gastroenterology & Hepatology
Neeraj Narula, Emily C. L. Wong, Parambir S. Dulai, Neil K. Sengupta, John K. Marshall, Jean-Frederic Colombel, Walter Reinisch
Summary: This post hoc analysis suggests that infliximab and ustekinumab have similar efficacy and speed of onset in biologic-naive patients with CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Benjamin L. Gordon, Robert Battat
Summary: Therapeutic drug monitoring (TDM) is a useful strategy in ulcerative colitis (UC), particularly in acute severe UC (ASUC). While there is limited data available for the use of TDM of infliximab in ASUC, observational data suggest that higher serum infliximab concentrations and lower clearance are associated with better clinical outcomes and decreased rates of colectomy. However, more studies are needed to evaluate optimal dosing and TDM targets in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Michael T. Dolinger, Elizabeth A. Spencer, Joanne Lai, David Dunkin, Marla C. Dubinsky
Summary: In this study, 16 pediatric IBD patients received dual therapy after failing two or more biologic therapies, with 75% achieving steroid-free remission at 6 months. There were improvements in erythrocyte sedimentation rate, C-reactive protein, and albumin levels. More research is needed to confirm the safety of dual therapy in this patient population.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Biology
Layla Parast, Tianxi Cai, Lu Tian
Summary: In studies requiring long-term and/or costly follow-up, surrogate markers are often used to evaluate the treatment effect. However, existing statistical methods often fail to account for the potential variation in the utility or strength of surrogate markers based on patient characteristics. This paper proposes an approach to measure surrogate strength as a function of baseline covariate and examines potential heterogeneity in surrogate marker utility.
Article
Biology
Jue Hou, Stephanie F. Chan, Xuan Wang, Tianxi Cai
Summary: This paper aims to develop an efficient risk prediction model for disease onset time by leveraging a small number of labels on the current status and a large number of unlabeled observations on imperfect proxies. By combining information from proxies and limited labels, the proposed semisupervised risk prediction method improves the accuracy of estimations. Simulation studies and a real case analysis demonstrate the good performance of the method in a finite sample.
Article
Mathematical & Computational Biology
Yuri Ahuja, Liang Liang, Doudou Zhou, Sicong Huang, Tianxi Cai
Summary: Leveraging large-scale electronic health record (EHR) data to estimate survival curves for clinical events is crucial for risk estimation and comparative effectiveness research. However, the lack of direct event time observations hinders the use of EHR data. In this article, the authors propose SCORNET, a method that utilizes current status labels and informative features to achieve consistent and efficient survival function estimation.
Article
Rheumatology
Sicong Huang, Tianrun Cai, Brittany N. Weber, Zeling He, Kumar P. Dahal, Chuan Hong, Jue Hou, Thany Seyok, Andrew Cagan, Marcelo F. DiCarli, Jacob Joseph, Seoyoung C. Kim, Daniel H. Solomon, Tianxi Cai, Katherine P. Liao
Summary: This study found that elevated inflammation early in the diagnosis of rheumatoid arthritis (RA) was associated with heart failure, specifically heart failure with preserved ejection fraction (HFpEF). The association was not observed with heart failure with reduced ejection fraction (HFrEF). This finding suggests a window of opportunity for prevention of HFpEF in RA patients.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Clinical Neurology
Liang Liang, Nicole Kim, Jue Hou, Tianrun Cai, Kumar Dahal, Chen Lin, Sean Finan, Guergana Savovoa, Mattia Rosso, Mariann Polgar-Tucsanyi, Howard Weiner, Tanuja Chitnis, Tianxi Cai, Zongqi Xia
Summary: This study examines the electronic health records (EHR) indicators of disease activity in multiple sclerosis (MS) patients. The results show that the frequency of diagnostic codes, procedure codes, emergency room visits, and electronic prescriptions for steroids declined over time, consistent with the trend of yearly incident relapse rate. These findings highlight the potential of using EHR data for large-scale examination of long-term disease activities or individual patient monitoring in clinical settings.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Biology
Xuan Wang, Layla Parast, Larry Han, Lu Tian, Tianxi Cai
Summary: Identifying effective surrogate markers is crucial for improving clinical trial efficiency. Replacing long-term outcomes with shorter-term and/or cheaper surrogate markers can shorten study duration and reduce costs. However, methods for combining multiple markers to construct a composite marker with improved surrogacy are limited.
Article
Gastroenterology & Hepatology
William Yuan, Jayson S. Marwaha, Shana T. Rakowsky, Nathan P. Palmer, Isaac S. Kohane, David T. Rubin, Gabriel A. Brat, Joseph D. Feuerstein
Summary: Population-scale analysis reveals patterns in prescribing trends for ulcerative colitis management, including earlier use of biologics, associations of step-up therapy with higher corticosteroid exposure, and association of combination therapy with positive patient outcomes.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, General & Internal
Chuan Hong, Harrison G. Zhang, Sehi L'Yi, Griffin Weber, Paul Avillach, Bryce W. Q. Tan, Alba Gutierrez-Sacristan, Clara-Lea Bonzel, Nathan P. Palmer, Alberto Malovini, Valentina Tibollo, Yuan Luo, Meghan R. Hutch, Molei Liu, Florence Bourgeois, Riccardo Bellazzi, Luca Chiovato, Fernando J. Sanz Vidorreta, Trang T. Le, Xuan Wang, William Yuan, Antoine Neuraz, Vincent Benoit, Bertrand Moal, Michele Morris, David A. Hanauer, Sarah Maidlow, Kavishwar Wagholikar, Shawn Murphy, Hossein Estiri, Adeline Makoudjou, Patric Tippmann, Jeffery Klann, Robert W. Follett, Nils Gehlenborg, Gilbert S. Omenn, Zongqi Xia, Arianna Dagliati, Shyam Visweswaran, Lav P. Patel, Danielle L. Mowery, Emily R. Schriver, Malarkodi Jebathilagam Samayamuthu, Ramakanth Kavuluru, Sara Lozano-Zahonero, Daniela Zoeller, Amelia L. M. Tan, Byorn W. L. Tan, Kee Yuan Ngiam, John H. Holmes, Petra Schubert, Kelly Cho, Yuk-Lam Ho, Brett K. Beaulieu-Jones, Miguel Pedrera-Jimenez, Noelia Garcia-Barrio, Pablo Serrano-Balazote, Isaac Kohane, Andrew South, Gabriel A. Brat, T. Cai
Summary: This study examined changes in international mortality rates and laboratory recovery rates during hospitalization for patients with SARS-CoV-2 infection between the first and second waves of the COVID-19 pandemic. The study found that while admission profiles did not differ greatly, the laboratory improvement rates were faster in the second wave and mortality risks decreased among patients with similar risk profiles.
Article
Urology & Nephrology
James A. Diao, Gloria J. Wu, Jason K. Wang, Isaac S. Kohane, Herman A. Taylor, Hocine Tighiouart, Andrew S. Levey, Lesley A. Inker, Neil R. Powe, Arjun K. Manrai
Summary: The newly recommended 2021 CKD-EPI creatinine-based eGFR equation may result in substantial changes to recommended care for US patients of all racial and ethnic groups.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Statistics & Probability
Xinzhou Guo, Waverly Wei, Molei Liu, Tianxi Cai, Chong Wu, Jingshen Wang
Summary: In this study, a new data analysis pipeline and statistical methodology were introduced to address the limitations of previous research on the association between statin usage and the risk of developing type II diabetes. The study found that females with high genetic risk for diabetes are the most vulnerable subgroup for developing diabetes after taking statins.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Mathematical & Computational Biology
Layla Parast, Tianxi Cai, Lu Tian
Summary: The primary benefit of identifying a valid surrogate marker is the ability to use it in a future trial to test for a treatment effect with shorter follow-up time or less cost. However, previous work has shown potential heterogeneity in the utility of surrogate markers. Therefore, ignoring this heterogeneity may lead to inaccurate conclusions about the treatment effect. This article introduces a novel test that accounts for the heterogeneity in surrogate marker utility.
STATISTICS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Byorn W. L. Tan, Bryce W. Q. Tan, Amelia L. M. Tan, Emily R. Schriver, Alba Gutierrez-Sacristan, Priyam Das, William Yuan, Meghan R. Hutch, Noelia Garcia Barrio, Miguel Pedrera Jimenez, Noor Abu-el-rub, Michele Morris, Bertrand Moal, Guillaume Verdy, Kelly Cho, Yuk-Lam Ho, Lav P. Patel, Arianna Dagliati, Antoine Neuraz, Jeffrey G. Klann, Andrew M. South, Shyam Visweswaran, David A. Hanauer, Sarah E. Maidlow, Mei Liu, Danielle L. Mowery, Ashley Batugo, Adeline Makoudjou, Patric Tippmann, Daniela Zoeller, Gabriel A. Brat, Yuan Luo, Paul Avillach, Riccardo Bellazzi, Luca Chiovato, Alberto Malovini, Valentina Tibollo, Malarkodi Jebathilagam Samayamuthu, Pablo Serrano Balazote, Zongqi Xia, Ne Hooi Will Loh, Lorenzo Chiudinelli, Clara-Lea Bonzel, Chuan Hong, Harrison G. Zhang, Griffin M. Weber, Isaac S. Kohane, Tianxi Cai, Gilbert S. Omenn, John H. Holmes, Kee Yuan Ngiam
Summary: This retrospective observational study analyzed data from 12,891 COVID-19 patients and found that age, severe COVID-19, severe acute kidney injury (AKI), and ischemic heart disease were associated with worse mortality outcomes. The severity of AKI was associated with poorer kidney function recovery, while the use of remdesivir was associated with better recovery. In patients without chronic kidney disease, age, male sex, severe AKI, and hypertension were associated with post-AKI kidney function impairment. COVID-19-associated AKI was also linked to higher mortality and worse long-term kidney function recovery.
Article
Computer Science, Information Systems
Jacqueline Honerlaw, Yuk-Lam Ho, Francesca Fontin, Jeffrey Gosian, Monika Maripuri, Michael Murray, Rahul Sangar, Ashley Galloway, Andrew J. Zimolzak, Stacey B. Whitbourne, Juan P. Casas, Rachel B. Ramoni, David R. Gagnon, Tianxi Cai, Katherine P. Liao, J. Michael Gaziano, Sumitra Muralidhar, Kelly Cho
Summary: The development of phenotypes using electronic health records is a resource-intensive process. The Department of Veterans Affairs (VA) has developed a standard for phenotype metadata collection, called CIPHER, which improves upon existing methods by capturing algorithm context and validation approach. This standard is applicable across healthcare systems and is currently used in the largest healthcare system in the United States.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Psychiatry
Yi-han Sheu, Jiehuan Sun, Hyunjoon Lee, Victor M. Castro, Yuval Barak-Corren, Eugene Song, Emily M. Madsen, William J. Gordon, Isaac S. Kohane, Susanne E. Churchill, Ben Y. Reis, Tianxi Cai, Jordan W. Smoller
Summary: This study finds that applying machine learning models to clinical data can outperform clinicians in suicide risk stratification. The researchers use a landmark model framework, aligned with clinical practice, and a large electronic health record database to predict suicide-related behaviors. The models developed using this approach achieve high predictive performance across different prediction windows and settings.
PSYCHIATRY RESEARCH
(2023)
Article
Biochemical Research Methods
Jun Wen, Xiang Zhang, Everett Rush, Vidul A. Panickan, Xingyu Li, Tianrun Cai, Doudou Zhou, Yuk-Lam Ho, Lauren Costa, Edmon Begoli, Chuan Hong, J. Michael Gaziano, Kelly Cho, Junwei Lu, Katherine P. Liao, Marinka Zitnik, Tianxi Cai
Summary: Predicting molecule-disease indications and side effects can be enhanced by comprehensively mining semantic dependencies between molecules, diseases, and diseases. This study introduces a Multi-Modal REpresentation Mapping Approach to Predicting molecular-disease relations (M2REMAP), which incorporates clinical semantics from electronic health records (EHR) of 12.6 million patients. M2REMAP achieves significant improvements in prediction performance on indications and side effects by combining multimodal molecule representation and disease semantic embedding.