Paeonol Suppresses Neuroinflammatory Responses in LPS-Activated Microglia Cells

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

(2016) Niek G.J. Leus et al.   BIOCHEMICAL PHARMACOLOGY

Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases

(2016) B. García Bueno et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-κB Activation in Microglial Cells

(2015) Dunjing Wang et al.   INFLAMMATION

Anti-Inflammatory Activity of Tanshinone IIA in LPS-Stimulated RAW264.7 Macrophages via miRNAs and TLR4–NF-κB Pathway

(2015) Guanwei Fan et al.   INFLAMMATION

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

(2015) Dennis Y. Chuang et al.   Journal of Neuroinflammation

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease

(2015) N. Panicker et al.   JOURNAL OF NEUROSCIENCE

IVSE, isolated from Inula japonica,suppresses LPS-induced NO production via NF-κB and MAPK inactivation in RAW264.7 cells

(2015) Xi Chen et al.   LIFE SCIENCES

Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity

(2014) James A. Giles et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transcriptome meta-analysis reveals a central role for sex steroids in the degeneration of hippocampal neurons in Alzheimer’s disease

(2013) Jessica M Winkler et al.   BMC Systems Biology

Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis by regulating the balance between inflammatory and anti-inflammatory cytokines

(2013) Chun Wang et al.   INFLAMMATION RESEARCH

Purpurogallin exerts anti-inflammatory effects in lipopolysaccharide-stimulated BV2 microglial cells through the inactivation of the NF-κB and MAPK signaling pathways

(2013) HYE YOUNG PARK et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location

(2013) Tu Thi Ngoc Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages

(2013) Milena Sokolowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The arginine kinase in Zhikong scallop Chlamys farreri is involved in immunomodulation

(2012) Xiaowei Shi et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Neuroprotective Effects of Pretreatment with Propofol in LPS-Induced BV-2 Microglia Cells: Role of TLR4 and GSK-3β

(2012) Bo Gui et al.   INFLAMMATION

Sociodemographic characteristics, clinical factors, and genetic polymorphisms associated with Alzheimer's disease

(2012) Maria Aparecida Camargos Bicalho et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Growth-Inhibiting, Bactericidal, and Urease Inhibitory Effects of Paeonia lactiflora Root Constituents and Related Compounds on Antibiotic-Susceptible and -Resistant Strains of Helicobacter pylori

(2012) Luong Thi My Ngan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease

(2012) Sang-Ho Choi et al.   JOURNAL OF NEUROCHEMISTRY

Review: Systemic inflammation and Alzheimer's disease

(2012) C. Holmes   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Paeonol from Hippocampus kuda Bleeler suppressed the neuro-inflammatory responses in vitro via NF-κB and MAPK signaling pathways

(2012) S.W.A. Himaya et al.   TOXICOLOGY IN VITRO

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease

(2011) Jun Zhou et al.   BRAIN RESEARCH

Alzheimers Disease: Pathological Mechanisms and Recent Insights

(2011) Dana M. Niedowicz et al.   Current Neuropharmacology

Inflammation in the early stages of neurodegenerative pathology

(2011) Preeti J. Khandelwal et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation

(2011) S. Wang et al.   NEUROSCIENCE

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

(2010) Piet Eikelenboom et al.   Neurodegenerative Diseases

Inhibition of LPS-Induced iNOS, COX-2 and Inflammatory Mediator Expression by Paeonol through the MAPKs Inactivation in RAW 264.7 Cells

(2009) Hee-Sung Chae et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro

(2009) J.M. Dean et al.   BRAIN BEHAVIOR AND IMMUNITY

Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-α production

(2008) Guo-Ping Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway

(2008) Teresa F Pais et al.   Journal of Neuroinflammation