期刊
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
卷 30, 期 1, 页码 143-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2015.10.011
关键词
Amphotericin; Antifungal; Diabetes; Hematopoietic stem cell transplantation; Immunocompromised; Ketoacidosis; Isavuconazole; Leukemia
资金
- Astellas US
- Pfizer
- Gilead
- Merck Co., Inc.
Life-threatening infections from virulent, angioinvasive molds of the order Mucorales are being recognized with increasing frequency in immunosuppressed hosts. Advances in the understanding of pathogenesis, early diagnosis, and the recent availability of active, nontoxic drugs have improved the prospects for effective control and even cure of this devastating infection. However, rates of delayed diagnosis and mortality are still high, partially because of the low yield and complexity of culture-based and molecular diagnostic methods. Therefore, there is an urgent need for novel diagnostic modalities and effective therapeutic approaches.
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