期刊
NANOMEDICINE
卷 16, 期 28, 页码 2503-2519出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2021-0257
关键词
AS1411; breast cancer cells; cancer stem cells; EpDT3; photothermal therapy; silver nanotriangles
资金
- National Natural Science Foundation of China [81771980, 81571805]
- National Key Basic Research Program of China (973 Program) [2013CB933904]
This study demonstrated that AENTs specifically targeted breast cancer cells and cancer stem cells, and the photothermal therapy mediated by AENTs effectively inhibited tumor growth and metastasis.
Aim: This study aimed to construct AS1411 and EpDT3-conjugated PEGylated silver nanotriangles (AENTs) and assess their ability to target breast cancer and cancer stem cells, as well as the anti tumor and anti metastatic effects of AENTs-mediated photothermal therapy. Materials & methods: AENTs were constructed and characterized. The targeting properties, as well as anti tumor and anti metastatic activities, were evaluated in MDA-MB-231 breast cancer cells, cancer stem cells and breast cancer-bearing mice. Results: AENTs displayed excellent targeting property to breast cancer cells and cancer stem cells. AENTs-mediated photothermal therapy greatly inhibited (>45%) the migration and invasion of breast cancer cells, as well as tumor growth and lung metastasis in the mice. Conclusion: AENTs-mediated photothermal therapy might be an effective strategy for the treatment of breast cancer.
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