NIR-light triggered dual-cascade targeting core-shell nanoparticles enhanced photodynamic therapy and immunotherapy

A Near-Infrared-II Polymer with Tandem Fluorophores Demonstrates Superior Biodegradability for Simultaneous Drug Tracking and Treatment Efficacy Feedback

(2021) Dengshuai Wei et al.   ACS Nano

Photoacoustic molecular imaging-escorted adipose photodynamic–browning synergy for fighting obesity with virus-like complexes

(2021) Ronghe Chen et al.   Nature Nanotechnology

A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

(2021) Yanmei He et al.   Science Advances

Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy

(2020) Hongzhang Deng et al.   NANO LETTERS

Aptamer/Peptide‐Functionalized Genome‐Editing System for Effective Immune Restoration through Reversal of PD‐L1‐Mediated Cancer Immunosuppression

(2020) Xiao‐Yan He et al.   ADVANCED MATERIALS

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

(2020) Johannes Karges et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

(2020) Jackie E. Bader et al.   MOLECULAR CELL

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

(2020) Hongzhang Deng et al.   Nature Communications

Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models

(2020) Dengshuai Wei et al.   ACS Nano

Responsive and activable nanomedicines for remodeling the tumor microenvironment

(2020) Yinlong Zhang et al.   Nature Protocols

Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment

(2019) Ningqiang Gong et al.   Nature Nanotechnology

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

(2019) Wenjia Zhang et al.   Nature Communications

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

(2019) Wei Li et al.   Nature Communications

Gold-DNA nanosunflowers for efficient gene silencing with controllable transformation

(2019) Shuaidong Huo et al.   Science Advances

Optochemical Control of Biological Processes in Cells and Animals

(2018) Nicholas Ankenbruck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potential applications and human biosafety of nanomaterials used in nanomedicine

(2017) Hong Su et al.   JOURNAL OF APPLIED TOXICOLOGY

Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules

(2017) Aneesh T. Veetil et al.   Nature Nanotechnology

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Three-Dimensional Cell Culture: A Breakthrough in Vivo

(2015) Delphine Antoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A small-molecule dye for NIR-II imaging

(2015) Alexander L. Antaris et al.   NATURE MATERIALS

Nanoscale optomechanical actuators for controlling mechanotransduction in living cells

(2015) Zheng Liu et al.   NATURE METHODS

Aptamer photoregulation in vivo

(2014) Lele Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments

(2013) H Inoue et al.   CELL DEATH AND DIFFERENTIATION

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

The promise of optogenetics in cell biology: interrogating molecular circuits in space and time

(2010) Jared E Toettcher et al.   NATURE METHODS