期刊
NANO LETTERS
卷 22, 期 2, 页码 710-715出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c03890
关键词
Optomechanical sensor; mass spectrometry; multimode analysis; individual nanoparticle; biosensing
类别
资金
- European Commission through the VIRUSCAN FET-open project [731868]
- European Commission through the NOMLI ERC project [770933]
- Agence Nationale de la Recherche through the QuaSeRT Quantera project
- European Research Council (ERC) [770933] Funding Source: European Research Council (ERC)
This study demonstrates a multimode optomechanical sensor for detecting individual nanoparticles and obtaining multiple physical information in real time. The device is optimized for investigating high megadalton biological particles.
We demonstrate multimode optomechanical sensing of individual nanoparticles with a radius between 75 and 150 nm. A semiconductor optomechanical disk resonator is optically driven and detected under ambient conditions, as nebulized nanoparticles land on it. Multiple mechanical and optical resonant signals of the disk are tracked simultaneously, providing access to several pieces of physical information about the landing analyte in real time. Thanks to a fast camera registering the time and position of landing, these signals can be employed to weight each nanoparticle with precision. Sources of error and deviation are discussed and modeled, indicating a path to evaluate the elasticity of the nanoparticles on top of their mere mass. The device is optimized for the future investigation of biological particles in the high megadalton range, such as large viruses.
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