4.8 Article

Multimode Optomechanical Weighting of a Single Nanoparticle

期刊

NANO LETTERS
卷 22, 期 2, 页码 710-715

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c03890

关键词

Optomechanical sensor; mass spectrometry; multimode analysis; individual nanoparticle; biosensing

资金

  1. European Commission through the VIRUSCAN FET-open project [731868]
  2. European Commission through the NOMLI ERC project [770933]
  3. Agence Nationale de la Recherche through the QuaSeRT Quantera project
  4. European Research Council (ERC) [770933] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

This study demonstrates a multimode optomechanical sensor for detecting individual nanoparticles and obtaining multiple physical information in real time. The device is optimized for investigating high megadalton biological particles.
We demonstrate multimode optomechanical sensing of individual nanoparticles with a radius between 75 and 150 nm. A semiconductor optomechanical disk resonator is optically driven and detected under ambient conditions, as nebulized nanoparticles land on it. Multiple mechanical and optical resonant signals of the disk are tracked simultaneously, providing access to several pieces of physical information about the landing analyte in real time. Thanks to a fast camera registering the time and position of landing, these signals can be employed to weight each nanoparticle with precision. Sources of error and deviation are discussed and modeled, indicating a path to evaluate the elasticity of the nanoparticles on top of their mere mass. The device is optimized for the future investigation of biological particles in the high megadalton range, such as large viruses.

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