Review
Infectious Diseases
Maiken C. Arendrup, Gunnar Kahlmeter, Jesus Guinea, Joseph Meletiadis
Summary: This article describes the new method released by the European Committee on Antimicrobial Susceptibility Testing Subcommittee on Antifungal Susceptibility Testing (EUCAST-AFST) for antifungal susceptibility testing against microconidia-forming dermatophytes. The method is based on the EUCAST microdilution method for moulds with significant alterations to accommodate dermatophytes, and has been validated for several antifungal drugs against Trichophyton rubrum and T. interdigitale.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Michael Joshua Hendrix, Lindsey Larson, Adriana M. Rauseo, Sasinuch Rutjanawech, Alexander D. Franklin, William G. Powderly, Andrej Spec
Summary: In a single-center retrospective cohort study, voriconazole was associated with increased short-term mortality in histoplasmosis compared to itraconazole.
CLINICAL INFECTIOUS DISEASES
(2021)
Letter
Mycology
Ananta Khurana, Aastha Agarwal, Diksha Agrawal, Kabir Sardana, Ashutosh Singh, Anuradha Chowdhary
Summary: Due to increasing drug resistance and erratic clinical responses, treatment options for refractory dermatophytosis are limited. However, refractory dermatophytosis has become a significant public health issue in India in recent years. This article presents a patient who failed four systemic antifungals sequentially but was cured with a 2-week course of voriconazole, an antifungal not commonly used for dermatophytosis.
JOURNAL DE MYCOLOGIE MEDICALE
(2022)
Article
Microbiology
Anne-Laure Bidaud, Patrick Schwarz, Anuradha Chowdhary, Eric Dannaoui
Summary: A combination of terbinafine with itraconazole was found to have synergistic effects against both terbinafine-susceptible and terbinafine-resistant isolates of Trichophyton spp. from India.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Aya Roshdy, Heba Elmansi, Shereen Shalan, Amina El-Brashy
Summary: A new high performance liquid chromatography method was developed using a 2(3) full factorial design model to estimate three antifungal drugs simultaneously. The method demonstrated successful separation and estimation of fluconazole, itraconazole, and terbinafine with high sensitivity, providing an important reference for the treatment of severe fungal infections.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Kazuhiro Ito
Summary: This review discusses the limitations of current antifungal therapy, the benefits of inhaled antifungal agents, the clinical development of inhaled antifungal triazoles, and the challenges of developing inhaled antifungal agents. Inhaled antifungal treatment provides an attractive option by changing the risk benefit ratio of treatment. Clinical studies have shown that new inhaled antifungal triazoles are well tolerated. However, there are still challenges and unresolved issues that need to be addressed.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Veterinary Sciences
Jared A. Jaffey, Eric T. Hostnik, Aline Rodrigues Hoffman, Maureen Jay, Sylvia H. Ferguson, Nathan P. Wiederhold
Summary: This is a case of Conidiobolus lamprauges rhinitis in a Goldendoodle, successfully treated with systemic antifungal therapy. The report describes important clinical features of the disease for recognition, prognostication, and treatment in clinical practice.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Keyvan Pakshir, Mandana Kamali, Hasti Nouraei, Kamiar Zomorodian, Marjan Motamedi, Mozhgan Mahmoodi
Summary: This study aimed to identify non-dermatophyte molds causing onychomycosis and evaluate antifungal activities against the isolates. Most of the samples were sensitive to terbinafine, itraconazole, and econazole, while 94% of the isolates were resistant to fluconazole. Aspergillus species were the most common cause of non-dermatophyte mold onychomycosis, with fluconazole being the most resistant antifungal.
SCIENTIFIC REPORTS
(2021)
Article
Mycology
Zhimin Duan, Jianbo Tong, Nana Zheng, Rong Zeng, Yuzhen Liu, Min Li
Summary: This study evaluated the efficacy of combining the antiarrhythmic drug AMD with triazole drugs for Aspergillus spp. infection. The results showed that the combination of AMD with itraconazole or posaconazole had synergistic fungicidal effects on Aspergillus biofilms.
Article
Infectious Diseases
Rosanne Sprute, Eva Van Braeckel, Holger Flick, Martin Hoenigl, Chris Kosmidis, Ritesh Agarwal, Jesper R. Davidsen, Christian B. Laursen, Oliver A. Cornely, Danila Seidel
Summary: This study aims to develop a scoring tool to quantify guideline adherence in the clinical management of CPA. A total of 27 recommendations were collected and weighed based on their strength and level of evidence. The EQUAL CPA Score is designed to be a comprehensive tool for measuring guideline adherence.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Veterinary Sciences
Michael S. McEntire, Jennifer M. Reinhart, Sherry K. Cox, Krista A. Keller
Summary: This study investigated the antifungal susceptibility of Nanniziopsis guarroi isolates and the pharmacokinetics of orally administered terbinafine in bearded dragons. Results showed that plasma terbinafine concentrations remained at effective levels in bearded dragons for an extended period post-administration.
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2022)
Review
Clinical Neurology
Hengameh B. Pajer, Anthony M. Asher, Aaron Gelinne, Weston Northam, David van Duin, Carolyn S. Quinsey
Summary: Cerebral aspergillosis has a high mortality rate, but surgical resection and the use of voriconazole or itraconazole have been shown to significantly improve patient survival.
WORLD NEUROSURGERY
(2021)
Article
Microbiology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: This article describes a case of tinea incognito in a man who developed a dermatophyte infection after the improper use of glucocorticoids. Tinea incognito can be challenging to diagnose due to its nonspecific clinical presentation and the lack of universally available diagnostic tests, such as culture or histopathological examination.
Article
Multidisciplinary Sciences
Yutao Lou, Feifeng Song, Mengting Cheng, Ying Hu, Yitao Chai, Qing Hu, Qiyue Wang, Hongying Zhou, Meihua Bao, Jinping Gu, Yiwen Zhang
Summary: This study investigated the influence of three triazole antifungals (voriconazole, itraconazole, and fluconazole) on the pharmacokinetics of osimertinib in rats. The results showed that voriconazole and fluconazole significantly changed the pharmacokinetics of osimertinib, while itraconazole had a slight effect.
Article
Chemistry, Medicinal
Hui-jun Wang, Chun-yan Zhou, Yan-ding Su, Kai-feng Gou, Xiao-nan Geng, Xiang-jun Qiu
Summary: A new UPLC-MS/MS technique was developed to determine ripretinib in beagle dog plasma, and it was found that itraconazole and voriconazole could inhibit ripretinib metabolism in beagle dogs, leading to increased plasma exposure of ripretinib.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)