Article
Biochemistry & Molecular Biology
Yuria Jang, Hong Moon Sohn, Young Jong Ko, Hoon Hyun, Wonbong Lim
Summary: The mutant RANKL demonstrated the ability to inhibit osteoclastogenesis by competitively inhibiting RANKL, serving as a potential therapeutic agent for osteoporosis with fewer toxic side effects compared to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Anuj Anuj, Nina Reuven, Stefan G. E. Roberts, Ari Elson
Summary: The cytokine RANKL is involved in the differentiation of monocytes/macrophages into bone-resorbing osteoclasts, and it down-regulates the expression of BASP1 which is a negative regulator of osteoclastogenesis. Knocking down or eliminating BASP1 enhances RANKL-induced osteoclastogenesis, promoting cell-cell fusion and increasing mineral degrading abilities of osteoclasts.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jiarui Li, Xiang Li, Shengji Zhou, Yuxin Wang, Yang Lu, Quan Wang, Fengchao Zhao
Summary: Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting TRAIL degradation and promotes osteoblast differentiation, suggesting its potential in anti-osteopenia pharmacotherapy.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Honglei Kang, Qian Guo, Yimin Dong, Renpeng Peng, Kehan Song, Jia Wang, Haiyang Liu, Meipeng Zhu, Hongjian Zhao, Hanfeng Guan, Feng Li
Summary: MAT2A is crucial for osteoclastogenesis and may be a potential therapeutic target for the treatment of osteoporosis.
Article
Immunology
Jiachao Guo, Ranyue Ren, Zhou Guo, Kai Sun, Jinpeng He, Jingfan Shao, Xiaolin Wang
Summary: Osteoporosis is a systemic and endocrine bone disorder characterized by decreased bone mineral density, compromised bone strength, and destruction of trabecular structure. The excessive osteoclastogenesis and bone erosion contribute to the progression of the disease. However, existing medications have poor adherence and adverse reactions, highlighting the urgent need for novel therapies for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Seon-A Jang, Youn-Hwan Hwang, Hyun Yang, Jin Ah Ryuk, Dong Ryun Gu, Hyunil Ha
Summary: The study found that the extract of Pyrrosia lingua has anti-osteoporotic effects by suppressing the differentiation of osteoclasts and preventing trabecular bone loss in mice. The researchers also identified phytochemicals in the extract that have known anti-osteoclastogenic or anti-osteoporotic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mingchao Jin, Jiangbo Nie, Juli Zhu, Jing Li, Tianshun Fang, Juntao Xu, Xuesheng Jiang, Zhuo Chen, Jianyou Li, Fengfeng Wu
Summary: This study demonstrated for the first time that acacetin inhibited osteoclastogenesis, bone resorption activity, and related gene expression by modulating multiple signaling pathways, suggesting its potential therapeutic effects for preventing osteoporosis and other osteolytic disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Hao Qu, Yuankang Zhang, Rongxin He, Nong Lin, Cong Wang
Summary: Postmenopausal osteoporosis is a chronic systemic metabolic disease caused by excessive bone resorption and reduced bone formation. Anethole, a natural compound, shows potential in inhibiting osteoclast differentiation, reducing bone resorption, and suppressing osteoclast-specific gene expression through blocking ERK and AKT signaling pathways. Our study suggests that anethole may have osteoprotective effects and be a potential treatment for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Gang Wang, Kai Chen, Chao Ma, Chao Wang, Delong Chen, Jianbo He, Yuhao Liu, Tao Jiang, Jinbo Yuan, Leilei Chen, Wei He, Jiake Xu
Summary: RA is a natural compound that shows potential therapeutic effects by inhibiting osteoclast differentiation and reducing bone loss. It suppresses osteoclastogenesis without causing cell toxicity, making it a promising treatment option for skeletal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Materials Science, Biomaterials
Sihan Hu, Yuan Xue, Jiachen He, Chichi Chen, Jie Sun, Yesheng Jin, Yuanshu Zhang, Qin Shi, Yongjun Rui
Summary: This study found that irisin protected against wear-particle-induced osteolysis in mice by inhibiting osteoclast activation and promoting bone homeostasis, offering a potential therapeutic strategy for the management of osteolysis and prosthetic loosening.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Iolanda Augusta Fernandes de Matos, Natalie Aparecida Rodrigues Fernandes, Giovani Cirelli, Mariely Araujo de Godoi, Leticia Ribeiro de Assis, Luis Octavio Regasini, Carlos Rossa Junior, Morgana Rodrigues Guimaraes-Stabili
Summary: In this in vitro study, a newly synthesized chalcone T4 was found to inhibit osteoclast differentiation and activity and stimulate osteogenesis, indicating a promising therapeutic potential in osteolytic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Min Ma, Ao-yuan Fan, Zheng Liu, Li-qing Yang, Jun-ming Huang, Zhi-ying Pang, Feng Yin
Summary: Our study compared the effects of icariin and its metabolites on osteoclastogenesis and identified baohuoside I as the most effective compound. Baohuoside I inhibited osteoclast differentiation and bone resorptive activity in a dose-dependent manner. Mechanistically, it achieved this by attenuating the activation of the MAPK and NF-kB pathways and reducing the expression of uPAR. Overall, our study demonstrated that baohuoside I can inhibit osteoclast differentiation and protect against bone loss in postmenopausal osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Chia-Hsiao Kuo, Jiann-Yeu Chen, Chuan-Mu Chen, Cian Wei Huang, Ying-Ming Liou
Summary: This study evaluated the effects of varying concentrations of gelatin coating on the differentiation of osteoclasts, showing that increased gelatin coating concentrations attenuated cell differentiation and reduced actin ring formation during bone resorption. Additionally, higher gelatin concentrations suppressed TGF-beta signaling, impacting OC differentiation and bone matrix resorption in RANKL-induced osteoclastogenesis.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Wu Jianwei, Tian Ye, Wang Hongwei, Li Dachuan, Zou Fei, Jiang Jianyuan, Wang Hongli
Summary: Bone remodelling is a dynamic process involving bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclastogenesis can lead to osteolytic diseases, and the receptor activator of NF-kappa B ligand (RANKL) is considered to be an important regulator of osteoclastogenesis. Transforming growth factor beta-activated kinase 1 (TAK1) plays a significant role in RANKL-induced osteoclastogenesis by regulating multiple signaling pathways. Understanding the mechanisms of TAK1 in this process has potential implications for the treatment of osteolytic diseases.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Chao Liu, Yining Li, Ren Sheng, Xiaowan Han, Li Bao, Chenyin Wang, Weizhi Wang, Xinhai Jiang, Jiangxue Han, Lijuan Lei, Ni Li, Jing Zhang, Minghua Chen, Yan Li, Yexiang Wu, Shunwang Li, Yu Ren, Yanni Xu, Shuyi Si
Summary: The study demonstrated that the N-methylpyridine-chlorofuranformamide analog 3i1 shows promise in upregulating OPG activity, inhibiting RANKL-induced osteoclastogenesis, and promoting osteoblast differentiation, potentially serving as a new therapeutic agent for osteoporosis.
BIOORGANIC CHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Toshie Nagayasu-Tanaka, Takenori Nozaki, Koji Miki, Keigo Sawada, Masahiro Kitamura, Shinya Murakami
CLINICAL ORAL IMPLANTS RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
S. Miyauchi, J. Kitagaki, R. Masumoto, A. Imai, K. Kobayashi, A. Nakaya, S. Kawai, C. Fujihara, Y. Asano, M. Yamashita, M. Yanagita, S. Yamada, M. Kitamura, S. Murakami
JOURNAL OF DENTAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
M. Takedachi, M. Iyama, K. Sawada, K. Mori, S. Yamamoto, C. Morimoto, M. Yanagita, S. Murakami
JOURNAL OF PERIODONTAL RESEARCH
(2017)
Article
Endocrinology & Metabolism
Shinji Kawai, Ikumi Michikami, Jirouta Kitagaki, Kenji Hata, Hiroshi Kiyonari, Takaya Abe, Atsuo Amano, Satoshi Wakisaka
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
R. Masumoto, J. Kitagaki, M. Matsumoto, S. Miyauchi, C. Fujihara, M. Yamashita, S. Yamada, M. Kitamura, S. Murakami
JOURNAL OF PERIODONTAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
Keisuke Handa, Syouta Abe, V. Venkata Suresh, Yoshiyasu Fujieda, Masaki Ishikawa, Ai Orimoto, Yoko Kobayashi, Satoru Yamada, Satoko Yamaba, Shinya Murakami, Masahiro Saito
ARCHIVES OF ORAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Mariane Maffei Azuma, Pooja Balani, Heike Boisvert, Mindy Gil, Kenji Egashira, Tsuguno Yamaguchi, Hatice Hasturk, Margaret Duncan, Toshihisa Kawai, Alexandru Movila
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Dentistry, Oral Surgery & Medicine
Shinya Murakami, Brian L. Mealey, Angelo Mariotti, Iain L. C. Chapple
JOURNAL OF CLINICAL PERIODONTOLOGY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Iain L. C. Chapple, Brian L. Mealey, Thomas E. Van Dyke, P. Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L. Geisinger, Robert J. Genco, Michael Glogauer, Moshe Goldstein, Terrence J. Griffin, Palle Holmstrup, Georgia K. Johnson, Yvonne Kapila, Niklaus P. Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A. Romito, Lior Shapira, Dimitris N. Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
JOURNAL OF CLINICAL PERIODONTOLOGY
(2018)
Article
Multidisciplinary Sciences
Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Yukie Masui, Taturo Ishizaki, Yasumichi Arai, Hiroki Inagaki, Takeshi Nakagawa, Mai Kabayama, Hirochika Ryuno, Hitomi Okubo, Hajime Takeshita, Chisato Inomata, Yuko Kurushima, Yusuke Mihara, Kohdai Hatta, Motoyoshi Fukutake, Kaori Enoki, Taiji Ogawa, Ken-ichi Matsuda, Ken Sugimoto, Ryosuke Oguro, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi, Shinya Murakami, Masahiro Kitamura, Yoshinobu Maeda
Article
Geriatrics & Gerontology
Kodai Hatta, Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Yukie Masui, Hiroki Inagaki, Takeshi Nakagawa, Ken-ichi Matsuda, Taiji Ogawa, Chisato Inomata, Hajime Takeshita, Yusuke Mihara, Motoyoshi Fukutake, Masahiro Kitamura, Shinya Murakami, Mai Kabayama, Tatsuro Ishizaki, Yasumichi Arai, Ken Sugimoto, Hiromi Rakugi, Yoshinobu Maeda
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2018)
Article
Cell Biology
Chiharu Fujihara, Yu Kanai, Risa Masumoto, Jirouta Kitagaki, Masahiro Matsumoto, Satoru Yamada, Tetsuhiro Kajikawa, Shinya Murakami
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Dentistry, Oral Surgery & Medicine
Risa Masumoto, Jirouta Kitagaki, Chiharu Fujihara, Masahiro Matsumoto, Shizuka Miyauchi, Yoshihiro Asano, Atsuko Imai, Kaori Kobayashi, Akihiro Nakaya, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami
JOURNAL OF PERIODONTAL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Venkata Suresh Venkataiah, Keisuke Handa, Mary M. Njuguna, Tatsuya Hasegawa, Kentaro Maruyama, Eiji Nemoto, Satoru Yamada, Shunji Sugawara, Lu Lu, Masahide Takedachi, Shinya Murakami, Hanayuki Okura, Akifumi Matsuyama, Masahiro Saito
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Tomoaki Iwayama, Tomoko Okada, Tsugumi Ueda, Kiwako Tomita, Shuji Matsumoto, Masahide Takedachi, Satoshi Wakisaka, Takeshi Noda, Taku Ogura, Tomomichi Okano, Peter Fratzl, Toshihiko Ogura, Shinya Murakami