Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of >45 residues

(2021) Sujan Devkota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ (Amyloid Beta) and Tau Tangle Pathology Modifies the Association Between Small Vessel Disease and Cortical Microinfarcts

(2021) A. Kapasi et al.   STROKE

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis

(2021) Panchanan Maiti et al.   Alzheimers Research & Therapy

Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-brain Barrier in Alzheimer’s Disease

(2021) Rui Zhou et al.   Current Alzheimer Research

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

(2021) Yuxing Xia et al.   Molecular Neurodegeneration

Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

(2021) Anton Malkov et al.   Communications Biology

SIRT5 Represses Neurotrophic Pathways and Aβ Production in Alzheimer’s Disease by Targeting Autophagy

(2021) Shanshan Wu et al.   ACS Chemical Neuroscience

Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review

(2021) Yong-shou Liu et al.   Frontiers in Psychiatry

Aβ monomer induces phosphorylation of Tau at Ser‐214 through β2AR‐PKA‐JNK signaling pathway

(2020) Hao Wu et al.   FASEB JOURNAL

Resistance Exercise Decreases Amyloid Load and Modulates Inflammatory Responses in the APP/PS1 Mouse Model for Alzheimer’s Disease

(2020) Debora Hashiguchi et al.   JOURNAL OF ALZHEIMERS DISEASE

Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

(2020) Krystal Sotolongo et al.   Alzheimers Research & Therapy

Berberine attenuates Aβ-induced neuronal damage through regulating miR-188/NOS1 in Alzheimer’s disease

(2020) Manman Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Quantitative Study of the Changes in Cerebral Blood Flow and Iron Deposition During Progression of Alzheimer’s Disease

(2020) Dongxue Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Shenzao jiannao oral liquid, an herbal formula, ameliorates cognitive impairments by rescuing neuronal death and triggering endogenous neurogenesis in AD-like mice induced by a combination of Aβ42 and scopolamine

(2020) Honghe Xiao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Environmental toxins and Alzheimer's disease progression

(2020) Maryam Vasefi et al.   NEUROCHEMISTRY INTERNATIONAL

RP1, a RAGE antagonist peptide, can improve memory impairment and reduce Aβ plaque load in the APP/PS1 mouse model of Alzheimer's disease

(2020) Yi-yun Huang et al.   NEUROPHARMACOLOGY

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

Increased cerebral blood flow with increased amyloid burden in the preclinical phase of alzheimer's disease

(2019) Amir Fazlollahi et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Early Aβ reduction prevents progression of cerebral amyloid angiopathy

(2019) Juliane Schelle et al.   ANNALS OF NEUROLOGY

Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden

(2019) Gisela Esquerda-Canals et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Diagnosis and Management of Dementia: Review

(2019) Zoe Arvanitakis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease

(2019) Heinz Hillen   Frontiers in Neuroscience

Changes in brain activation related to visuo-spatial memory after real-time fMRI neurofeedback training in healthy elderly and Alzheimer’s disease

(2019) Christian Hohenfeld et al.   BEHAVIOURAL BRAIN RESEARCH

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

RAGE mediates Aβ accumulation in a mouse model of Alzheimer’s disease via modulation of β- and γ-secretase activity

(2018) Fang Fang et al.   HUMAN MOLECULAR GENETICS

Activation of Neuronal Defense Mechanisms in Response to Pathogenic Factors Triggering Induction of Amyloidosis in Alzheimer's Disease

(2018) Alexander V. Maltsev et al.   JOURNAL OF ALZHEIMERS DISEASE

Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation

(2017) Elena Simoni et al.   Future Medicinal Chemistry

State of Play in Alzheimer’s Disease Genetics

(2017) Jin-Bao Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic treatments with a 5-HT 4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease

(2017) Kevin Baranger et al.   NEUROPHARMACOLOGY

Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice

(2017) Chunhui Zhao et al.   NEUROPHARMACOLOGY

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases

(2016) Gianluigi Forloni et al.   MOVEMENT DISORDERS

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice

(2016) Jonathan Gilley et al.   NEUROBIOLOGY OF AGING

Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms

(2016) Ying Du et al.   NEUROPHARMACOLOGY

Twenty-five years of the amyloid hypothesis of alzheimer disease: advances, failures and new perspectives

(2016) O. S. Levin et al.   Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy

(2016) José Marco-Contelles et al.   Frontiers in Neuroscience

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis

(2015) Jinkuk Choi et al.   Science Translational Medicine

Dangerous Liaisons between Beta-Amyloid and Cholinergic Neurotransmission

(2015) Stefano Govoni et al.   CURRENT PHARMACEUTICAL DESIGN

The 2013 SFRBM discovery award: Selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment

(2014) D. Allan Butterfield   FREE RADICAL BIOLOGY AND MEDICINE

Amyloidosis in Alzheimer’s Disease: The Toxicity of Amyloid Beta (Aβ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy

(2013) Anchalee Prasansuklab et al.   Evidence-based Complementary and Alternative Medicine

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide

(2013) Christian Peters et al.   NEUROBIOLOGY OF AGING

Amyloid-β Peptides and Tau Protein as Biomarkers in Cerebrospinal and Interstitial Fluid Following Traumatic Brain Injury: A Review of Experimental and Clinical Studies

(2013) Parmenion P. Tsitsopoulos et al.   Frontiers in Neurology

Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year

(2012) J. Winchester et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Reprint of “Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein”

(2012) George G. Glenner   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

(2012) Karlie A. Intlekofer et al.   NEUROBIOLOGY OF DISEASE

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Synaptic Mitochondrial Pathology in Alzheimer's Disease

(2011) Heng Du et al.   ANTIOXIDANTS & REDOX SIGNALING

APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells

(2011) Fangfang Zhou et al.   Protein & Cell

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

(2010) Rodrigo A. Fuentealba et al.   PLoS One

Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

(2010) Fernando J. Sepulveda et al.   PLoS One

Autophagy protects neuron from Aβ-induced cytotoxicity

(2009) Shih-Ya Hung et al.   Autophagy

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

β-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure

(2009) Jorge Parodi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

(2008) Ludovico Minati et al.   American Journal of Alzheimers Disease and Other Dementias

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE