Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery

Total Synthesis of Ritterazine B

(2021) Yasuaki Nakayama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents

(2021) Hongfen Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Favipiravir for the treatment of patients with COVID-19: a systematic review and meta-analysis

(2021) Toshie Manabe et al.   BMC INFECTIOUS DISEASES

Molecular Interactions of Pyrazine-Based Compounds to Proteins

(2020) Martin Juhás et al.   JOURNAL OF MEDICINAL CHEMISTRY

Essential Medicinal Chemistry of Essential Medicines

(2020) Marta Serafini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Cytotoxic Evaluation of N-Alkyl-2-halophenazin-1-ones

(2020) Haruki Kohatsu et al.   ACS Omega

Phenazine Antibiotic Inspired Discovery of Bacterial Biofilm-Eradicating Agents

(2019) Robert William Huigens III et al.   CHEMBIOCHEM

Have marine natural product drug discovery efforts been productive and how can we improve their efficiency?

(2019) Florbela Pereira   Expert Opinion on Drug Discovery

An Efficient Buchwald–Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration

(2018) Aaron T. Garrison et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transcript Profiling of MRSA Biofilms Treated with a Halogenated Phenazine Eradicating Agent: A Platform for Defining Cellular Targets and Pathways Critical to Biofilm Survival

(2018) Yasmeen Abouelhassan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Synthesis of Kinase Inhibitor AKN028

(2018) Ulf Bremberg et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Natural products from anaerobes

(2018) Jeffrey S. Li et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis

(2017) Hongfen Yang et al.   Scientific Reports

Structure–Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis

(2016) Aaron T. Garrison et al.   JOURNAL OF MEDICINAL CHEMISTRY

Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, andMycobacterium tuberculosis

(2015) Aaron T. Garrison et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Alocasin A

(2015) Se Hun Kim et al.   JOURNAL OF NATURAL PRODUCTS

Bortezomib in multiple myeloma: systematic review and clinical considerations

(2014) T.C. Kouroukis et al.   Current Oncology

Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

(2014) Concetta Imperatore et al.   MOLECULES

Systematic review of clofazimine for the treatment of drug-resistant tuberculosis [Review article]

(2013) M. Gopal et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Iron-catalyzed Cross-Coupling of Electron-Deficient Heterocycles and Quinone with Organoboron Species via Innate C–H Functionalization: Application in Total Synthesis of Pyrazine Alkaloid Botryllazine A

(2013) Parvinder Pal Singh et al.   JOURNAL OF ORGANIC CHEMISTRY

Transition metal-catalyzed functionalization of pyrazines

(2013) Nicolai I. Nikishkin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis

(2013) Nicholas V. Borrero et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Synthesis and Absolute Configuration of Streptophenazine G

(2012) Zhicai Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Pyrazine alkaloids via dimerization of amino acid-derived α-amino aldehydes: biomimetic synthesis of 2,5-diisopropylpyrazine, 2,5-bis(3-indolylmethyl)pyrazine and actinopolymorphol C

(2012) Sandhya Badrinarayanan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Discovery of 2-Hydroxymethyl-3-(3-methylbutyl)-5-methylpyrazine: A Semiochemical in Orchid Pollination

(2012) Björn Bohman et al.   ORGANIC LETTERS

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

(2012) A Eriksson et al.   Blood Cancer Journal

Synthesis of Dragmacidin D via Direct C–H Couplings

(2011) Debashis Mandal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural products reveal cancer cell dependence on oxysterol-binding proteins

(2011) Anthony W G Burgett et al.   Nature Chemical Biology

The Revised Structure, Total Synthesis, and Absolute Configuration of Streptophenazine A

(2011) Zhicai Yang et al.   ORGANIC LETTERS

Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines†† This review is dedicated to the community of isolation/identification natural product detectives, with special thanks to the groups of Bob Pettit and Nobuhiro Fusatani.

(2009) Seongmin Lee et al.   CHEMICAL REVIEWS

Bortezomib

(2009) Monique P. Curran et al.   DRUGS

Enantioselective Synthesis of (+)-Cephalostatin 1

(2009) Kevin C. Fortner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regio- and Chemoselective Multiple Functionalization of Chloropyrazine Derivatives. Application to the Synthesis of Coelenterazine

(2009) Marc Mosrin et al.   ORGANIC LETTERS

Synthesis and in vitro evaluation of botryllazine B analogues as a new class of inhibitor against human aldose reductase

(2009) Ryota Saito et al.   TETRAHEDRON