Expanded regulation of circular RNA translation

Chen et al. (2021) have identified many internal ribosome entry site-like elements that can potentially drive circRNA translation. Dozens of such element-containing circRNAs-encoded peptides are validated, among which a circFGFR1-encoded protein acts as an antagonist of FGFR1.

Automated summary

Researchers have identified internal ribosome entry site-like elements in circRNA that can potentially drive translation. Dozens of peptides encoded by circRNAs containing these elements have been validated, with one protein acting as an antagonist of FGFR1.