Review
Oncology
Charles Dai, Leif W. Ellisen
Summary: Aberrant estrogen receptor (ER) signaling plays a key role in the development of many breast cancers. The androgen receptor (AR), similar to ER, is frequently expressed in breast cancer and has been considered as a potential therapeutic target. However, the understanding of androgen signaling in breast cancer is incomplete and there are conflicting findings regarding the role of AR. This article summarizes the current understanding of AR biology and recent investigations into AR-directed therapies in breast cancer.
Article
Cell Biology
Shabnam Massah, Jane Foo, Na Li, Sarah Truong, Mannan Nouri, Lishi Xie, Gail S. Prins, Ralph Buttyan
Summary: ER alpha interacts with Gli3 in breast cancer cells, leading to Gli3 stabilization and increased expression of Gli-target genes with estradiol treatment. Additionally, Gli3 is found to be essential for breast cancer cell growth, suggesting that ER alpha-Gli interaction and Gli3 could be novel targets for controlling breast cancer growth effectively.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Deborah A. Finn
Summary: This review focuses on the contributions of the endocrine system to alcohol drinking and withdrawal in females, using animal models. It discusses the interactions between different steroid axes, the effects of chronic alcohol use on steroid levels, and the effects of steroids in alcohol drinking and withdrawal models. The divergent effects of sex and stress steroids on alcohol-related behaviors highlight the importance of considering sex in the development of novel pharmacotherapies for alcohol use disorder.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Tamarra James-Todd, Lisa Connolly, Emma V. Preston, Marlee R. Quinn, Monika Plotan, Yuling Xie, Bharathi Gandi, Shruthi Mahalingaiah
Summary: Hair products commonly used by Black women were found to exhibit hormonal activity, which could potentially impact health outcomes.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Oncology
Emanuele Perrone, Riccardo Tudisco, Pia Clara Pafundi, Davide Guido, Alessandra Ciucci, Enrica Martinelli, Gian Franco Zannoni, Alessia Piermattei, Saveria Spadola, Giulia Ferrante, Claudia Marchetti, Giovanni Scambia, Anna Fagotti, Daniela Gallo
Summary: This study explored the relationship between hormone receptor status and BRCA1/2 mutation in high-grade serous ovarian carcinoma (HGSOC) patients. The results showed interesting differences in receptor expression patterns and their association with outcomes between BRCA-mutated and BRCA wild-type women. The findings suggest a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential for targeting this interaction.
Review
Oncology
Darcie D. Seachrist, Lindsey J. Anstine, Ruth A. Keri
Summary: The review discusses the role of FOXA1 in regulating gene activity, cell biology, and the response of breast cancers to hormone therapies. It also highlights the potential for future studies to explore the roles of FOXA1 independent of its regulation of nuclear receptors.
Review
Endocrinology & Metabolism
Franck Mauvais-Jarvis, Carol A. Lange, Ellis R. Levin
Summary: Steroid hormones regulate physiological and disease processes through binding to receptors on the cell membrane and collaboration with receptors in the nucleus.
Article
Food Science & Technology
Baocai Xie, Dengke Pan, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu
Summary: Diosmetin treatment can reduce body weight and fat mass, improve glucose tolerance and insulin resistance by increasing energy expenditure through enhancing thermogenesis and browning of adipose tissue. Mechanistically, diosmetin acts as an agonist for estrogen receptors (ERs) to elevate their expression in adipose tissue, and the presence of ERs is essential for the metabolic benefits of diosmetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Plant Sciences
Yuhong Li, Shuying Hu, Yueqi Chen, Xing Zhang, Hanchi Gao, Jing Tian, Jian Chen
Summary: A novel estrogen receptor-alpha splice variant ER-α30 was found to be primarily localized in the nucleus of triple-negative breast cancer (TNBC) cells. ER-α30 was significantly overexpressed in breast cancer tissues of ER- and progesterone receptor (PR)-negative subtype as well as in TNBC cell lines compared to normal breast cell line MCF10A. ER-α30 overexpression promoted TNBC cell viability, migration, invasion, and epithelial-mesenchymal transition, while knockdown of ER-α30 had the opposite effects. Calycosin could suppress ER-α30 expression and inhibit TNBC growth and metastasis.
Review
Nanoscience & Nanotechnology
Namita Mahadik, Dwaipayan Bhattacharya, Akshaya Padmanabhan, Kalyani Sakhare, Kumar Pranav Narayan, Rajkumar Banerjee
Summary: Steroid hormone receptors, particularly the glucocorticoid receptor (GR), show potential as druggable targets for cancer treatment due to their aberrant expression patterns and context-specific regulation in cancer cells. Despite not fitting into the category of conventional cell surface receptors, efforts to develop SHR-targeted anticancer therapeutics, including nanodelivery systems and small molecules, are active in research.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Valeria C. Torres Irizarry, Yuwei Jiang, Yanlin He, Pingwen Xu
Summary: Obesity is a global epidemic and is associated with other metabolic disorders. Sex-specific metabolic protection and disease susceptibility play an important role, with estrogen hormone regulating fat distribution and metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengping Long, Chong You, Qianqian Song, Lina X. J. Hu, Zhaorong Guo, Qian Yao, Wei Hou, Wei Sun, Baosheng Liang, Xiaohua Zhou, Yiqiang Liu, Taobo Hu
Summary: This study analyzed the expression of androgen receptor (AR) in both estrogen receptor (ER)-positive and ER-negative breast cancer, and its association with clinicopathological and molecular features. The results showed that AR negativity was associated with different characteristics in ER-positive and ER-negative breast cancer. AR-positive breast cancer had better clinicopathological features, especially in the ER-negative subtype. These findings suggest a distinctive role of AR in ER-negative breast cancer compared to ER-positive breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ville Paakinaho, Jorma J. Palvimo
Summary: Recent studies indicate that interactions between steroid receptors in breast and prostate cancers can lead to the rewiring of gene programs, altering biological processes and impacting disease progression.
ENDOCRINE-RELATED CANCER
(2021)
Review
Oncology
Wojciech Kowalczyk, Grzegorz Waliszczak, Robert Jach, Joanna Dulinska-Litewka
Summary: Our knowledge of steroid receptor function in breast cancer is vast and constantly evolving. The family of steroid receptors plays a crucial role in the pathogenesis of the disease, regulating gene expression and interacting with other proteins. Understanding their complex nature is essential for the development of effective hormone therapies targeting breast cancer.
Review
Endocrinology & Metabolism
Shinjini Ganguly, Divya Naik, Andrew Muskara, Omar Y. Mian
Summary: The relationship between sex steroid hormone receptors and genomic stability has been studied, revealing various mechanisms including both direct and indirect pathways. Androgen and estrogen receptors modulate the cellular repair machinery by trans-activating DNA damage response genes. These findings have important implications for cancer prevention and treatment.
Article
Oncology
Olivier Tredan, Magali Provansal, Cyril Abdeddaim, Audrey Lardy-Cleaud, Anne-Claire Hardy-Bessard, Elsa Kalbacher, Anne Floquet, Laurence Venat-Bouvet, Alain Lortholary, Oana Pop, Jean-Sebastien Frenel, Mathilde Cancel, Remy Largillier, Christophe Louvet, Benoit You, Alain Zannetti, Amelie Anota, Isabelle Treilleux, Daniel Pissaloux, Aurelie Houlier, Aude-Marie Savoye, Marie-Ange Mouret-Reynier, Jerome Meunier, Charles-Briac Levache, Fabien Brocard, Isabelle Ray-Coquard
Summary: This study evaluated the efficacy and safety of regorafenib versus tamoxifen in platinum-sensitive ovarian cancer biological recurrence. The results showed regorafenib had a less favorable safety profile compared to tamoxifen, but no superior efficacy in this population of patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Alice Bonneville-Levard, Didier Frappaz, Olivier Tredan, Emilie Lavergne, Veronique Corset, Vincent Agrapart, Sylvie Chabaud, Daniel Pissaloux, Qing Wang, Valery Attignon, Stephanie Cartalat, Francois Ducray, Laure Thomas-Maisonneuve, Jerome Honnorat, David Meyronet, Luc Taillandier, Marie Blonski, Alain Viari, Christian Baudet, Emilie Sohier, Sylvie Lantuejoul, Sandrine Paindavoine, Isabelle Treilleux, Christine Rodriguez, David Perol, Jean-Yves Blay
Summary: Immunohistochemistry and recent molecular technologies have led to personalized anti-tumoral therapies for patients with advanced brain tumors. This study explored molecular profiling in these patients and identified actionable molecular alterations in some cases. However, only a small percentage of patients ultimately received molecular-based recommended therapy, with reasons including early death, lack of suitable clinical trials, or inappropriate results.
Article
Oncology
Philippe A. A. Cassier, Clementine Peyramaure, Valery Attignon, Lauriane Eberst, Camille Pacaud, Sandrine Boyault, Francoise Desseigne, Mathieu Sarabi, Pierre Guibert, Pauline Rochefort, Nathalie Marques, Michel Rivoire, Aurelien Dupre, Patrice Peyrat, Catherine Terret, Isabelle Ray-Coquard, Clelia Coutzac, David Perol, Jean-Yves Blay, Olivier Tredan, Christelle de la Fouchardiere
Summary: This study describes the mutational landscape and outcome of patients with gastroesophageal cancers enrolled in the ProfiLER program. It finds that genomic profiling can identify actionable alterations in a large proportion of patients, and that patients with stage IV disease at diagnosis who have an actionable alteration tend to have longer overall survival.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Benoite Mery, Elise Rowinski, Charlene Rivier, Wafa Bouleftour, Sandrine Sotton, Fabien Tinquaut, Laurent Bertoletti, Olivier Tredan, Nicolas Magne
Summary: Identification of risk factors and assessment of risk prediction model in a large population of breast cancer patients. Factors associated with cardiovascular events include high blood pressure, acute coronary syndrome, and Scarff-Blool-Richardson grade. Abdel-Qadir score was not fully validated in this population.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)
Meeting Abstract
Oncology
Felix Balazard, Aurelie Bertaut, Elise Bordet, Stephane Mulard, Julie Blanc, Nathalie Briot, Gautier Paux, Asma Dhaini Merimeche, Olivier Rigal, Charles Coutant, Marion Fournier, Christelle Jouannaud, Patrick Soulie, Florence Lerebours, Paul-Henri Cottu, Olivier Tredan, Laurence Vanlemmens, Christelle Levy, Marie-Ange Mouret-Reynier, Mario Campone, Keri J. S. Brady, Medha Sasane, Megan Rice, Catherine Coulouvrat, Anne-Laure Martin, Alexandra Jacquet, Ines Vaz-Luis, Christina Herold, Barbara Pistilli
Meeting Abstract
Oncology
Matteo Lambertini, Claudia Massarotti, Julie Havas, Barbara Pistilli, Anne-Laure Martin, Alexandra Jacquet, Charles Coutant, Florence Coussy, Asma Dhaini Merimeche, Florence Lerebours, Olivier Tredan, Christelle Jouannaud, Olivier Rigal, Marion Fournier, Patrick Soulie, Maria Alice Franzoi, Lucia Del Mastro, Ann H. Partridge, Fabrice Andre, Ines Vaz-Luis, Antonio Di Meglio
Article
Oncology
Elsa Caumette, Antonio Di Meglio, Ines Vaz-Luis, Cecile Charles, Julie Havas, Garazi Ruiz de Azua, Elise Martin, Laurence Vanlemmens, Suzette Delaloge, Sibille Everhard, Anne-Laure Martin, Asma Dhaini Merimeche, Olivier Rigal, Charles Coutant, Marion Fournier, Christelle Jouannaud, Patrick Soulie, Paul-Henri Cottu, Olivier Tredan, Gwenn Menvielle, Agnes Dumas
Summary: The return to work after breast cancer recovery is influenced by psychosocial factors, including a shift in life values towards more emphasis on private life. Clinical determinants, work-related factors, and psychosocial factors all play a role in this change. Depressive symptoms are negatively associated with this shift.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Florence Oberkampf, Maya Gutierrez, Olfa Trabelsi Grati, Emilie Le Rhun, Olivier Tredan, Isabelle Turbiez, Amir Kadi, Coraline Dubot, Sophie Taillibert, Sophie Vacher, Claire Bonneau
Summary: This study aimed to evaluate the efficacy of intrathecal trastuzumab in HER2 + BC patients with leptomeningeal metastasis. The results showed that weekly administration of 150 mg of intrathecal trastuzumab was effective in controlling neurological progression.
Article
Oncology
Olivier Tredan, Caroline Robert, Antoine Italiano, Fabrice Barlesi
Summary: Genome-wide testing plays a crucial role in advancing precision medicine in oncology; however, current recommendations lack specificity regarding its indications and utility for different types of cancer. To address this, a national consensus approach using a modified Delphi methodology was employed in France to provide expert opinions on the use of genome-wide testing in clinical practice. Consensus was reached through multiple rounds of rating, resulting in 24 statements agreed upon by the expert panel. While genome-wide testing was recommended for non-small cell lung cancer (NSCLC) and cancer of unknown primary (CUP), its routine use was not recommended for breast cancer and melanoma. The standardization of broad molecular screening in oncology may be facilitated by improved access to innovation in France.
BULLETIN DU CANCER
(2023)
Article
Oncology
Idlir Licaj, Elodie Coquan, Tienhan Sandrine Dabakuyo-Yonli, Sarah Dauchy, Ines Vaz Luis, Cecile Charles, Cedric Lemogne, Olivier Tredan, Laurence Vanlemmens, Christelle Jouannaud, Christelle Levy, Olivier Rigal, Marion Fournier, Thierry Petit, Florence Dalenc, Philippe Rouanet, Jerome Lemonnier, Sibille Everhard, Paul Cottu, Florence Joly
Summary: This study used the CANTO cohort to study the associations between baseline quality of life and chemotherapy dose-reductions (CDRs) or post-chemotherapy toxicities (PCTs). The results showed that baseline physical functioning and fatigue were associated with CDRs and PCTs.
Article
Oncology
Pauline Corbaux, Catherine Terret, Claire Cropet, Sylvie Chabaud, Chiara Russo, Christelle Faure, Olivier Tredan, Thomas Bachelot, Pierre-Etienne Heudel
Summary: This study aimed to examine the effect of additional chemotherapy on overall survival in patients aged 70 years or older with early breast cancer, as well as the impact of comorbidities on chemotherapy benefit. The results showed that additional chemotherapy was associated with improved overall survival, while chronic obstructive pulmonary disease and polypharmacy were associated with worse overall survival. These findings support the importance of chemotherapy considerations in elderly patients with early breast cancer.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Gisele Chvetzoff, Carole Bouleuc, Audrey Lardy-Cleaud, Pierre Saltel, Veronique Dieras, Magali Morelle, Jean-Paul Guastalla, Olivier Tredan, Paul Rebattu, Simona Pop, Isabelle Ray-Coquard, Jean-Yves Pierga, Laurent Mignot, Valerie Laurence, Valerie Bourne-Branchu, David Perol, Thomas Bachelot
Summary: This study compared the impact of early palliative care and usual oncology care on the decision for additional chemotherapy. The results showed no significant difference in the prescription rate of chemotherapy between the two groups, but the early palliative care group had less deterioration in physical functioning and improved information exchange and communication.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Houssein El Hajj, Domenico Ferraioli, Pierre Meus, Frederic Beurrier, Olivier Tredan, Isabelle Ray-Coquard, Nicolas Chopin
Summary: ObjectiveSplenectomy is performed in a significant percentage of cytoreductive surgeries for ovarian cancer. This study aimed to evaluate the impact of splenectomy on overall and disease-free survival in patients with epithelial ovarian cancer. MethodsA retrospective study was conducted on patients who underwent cytoreduction for ovarian cancer between January 2000 and December 2016. Patients were stratified into splenectomy and non-splenectomy groups, and postoperative complications and survival outcomes were analyzed. ResultsA total of 464 patients were included in the study. The splenectomy group had higher disease stages, peritoneal carcinomatosis scores, and radical surgery rates. However, there was no significant difference in complete cytoreduction rates between the two groups. Splenectomy was associated with extensive surgical procedures and increased risk of abdominopelvic lymphocele and blood transfusion. The average length of hospital stay and delay in adjuvant chemotherapy were longer in the splenectomy group. Overall and disease-free survival rates were not significantly different between the groups. ConclusionSplenectomy may be a safe procedure with no impact on overall or disease-free survival in patients with ovarian cancer. However, it is associated with longer hospital stay and delay in chemotherapy.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Multidisciplinary Sciences
Andrea Alegre-Marti, Alba Jimenez-Panizo, Adrian Martinez-Tebar, Coralie Poulard, M. Nuria Peralta-Moreno, Montserrat Abella, Rosa Anton, Marcos Chinas, Ulrich Eckhard, Josep M. Piulats, Ana M. Rojas, Juan Fernandez-Recio, Jaime Rubio-Martinez, Muriel Le Romancer, Alvaro Aytes, Pablo Fuentes-Prior, Eva Estebanez-Perpina
Summary: This study reveals that mutations of the androgen receptor (AR) associated with prostate cancer and androgen insensitivity syndrome can influence its structure and function, leading to altered transcription signatures and drug responses. These mutations induce an allosteric switch in the AR ligand-binding domain (AR-LBD), increasing exposure of a key methylation target and impacting AR-dependent transcription and response to anti-androgens. These findings have implications for precision medicine and understanding disease mechanisms.
Article
Oncology
Khalil Hodroj, David Pellegrin, Cindy Menard, Thomas Bachelot, Thierry Durand, Philippe Toussaint, Armelle Dufresne, Benoite Mery, Olivier Tredan, Thibaut Goulvent, Pierre Heudel
Summary: This study describes the implementation of an MDT application prototype based on structured data for ABC MDT meetings, which improved the quality and confidence of clinical decisions, and could support sustained improvements to patient care.
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
