The role of enteric dysbacteriosis and modulation of gut microbiota in the treatment of inflammatory bowel disease

The incidence of inflammatory bowel disease (IBD) is globally increasing. This disorder seriously affects the quality of life in patients. Interestingly, studies have detected that the intestinal flora imbalance is a critical factor in the progression of IBD. One potential treatment strategy for IBD involves regulating the composition and function of the intestinal flora. To date, a multitude of experiments have confirmed the relationship between intestinal flora, immune regulation, and anti-inflammation. The intestinal flora can reduce intestinal inflammation by regulating immunity and increasing the secretion of metabolic short-chain fatty acids. In this review, we discuss the composition and function of the intestinal flora, the relationship between the intestinal flora and the host, the role of intestinal flora disorders in IBD, and the progress in IBD treatment. Combining the regulation of the intestinal flora with probiotics treatment is considered a promising strategy for substantially improving the treatment of IBD.

Automated summary

The incidence of inflammatory bowel disease (IBD) is increasing globally and significantly impacts patients' quality of life. Imbalance in intestinal flora has been identified as a critical factor in the progression of IBD. Regulating the composition and function of the intestinal flora has emerged as a potential treatment strategy, with numerous experiments confirming the relationship between intestinal flora, immune regulation, and anti-inflammation.