标题
Regulation of NAD+ metabolism in aging and disease
作者
关键词
NAD, Niacin, Nicotinamide riboside, Nicotinamide adenine mononucleotide, Niacin receptor
出版物
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume 126, Issue -, Pages 154923
出版商
Elsevier BV
发表日期
2021-10-29
DOI
10.1016/j.metabol.2021.154923
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells
- (2021) Andrey Kropotov et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease
- (2021) Afzal Misrani et al. Frontiers in Aging Neuroscience
- Evolving concepts in NAD+ metabolism
- (2021) Claudia C.S. Chini et al. Cell Metabolism
- Cardiac Energy Metabolism in Heart Failure
- (2021) Gary D. Lopaschuk et al. CIRCULATION RESEARCH
- NAD + Repletion Reverses Heart Failure with Preserved Ejection Fraction
- (2021) Dan Tong et al. CIRCULATION RESEARCH
- Sex‐specific alterations in NAD+ metabolism in 3xTg Alzheimer’s disease mouse brain assessed by quantitative targeted LC‐MS
- (2021) Vera Velpen et al. JOURNAL OF NEUROCHEMISTRY
- Beyond mitochondria: Alternative energy-producing pathways from all strata of life
- (2021) Christopher Auger et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Dysregulation of cellular energetics in Gulf War Illness
- (2021) Raghavan Pillai Raju et al. TOXICOLOGY
- The Extracellular NADome Modulates Immune Responses
- (2021) Valentina Audrito et al. Frontiers in Immunology
- Structural and Functional Characterization of NadR from Lactococcus lactis
- (2020) Artem Stetsenko et al. MOLECULES
- Rapid senescence‐like response after acute injury
- (2020) Xiaogang Chu et al. AGING CELL
- Age-related NAD+ decline
- (2020) Melanie R. McReynolds et al. EXPERIMENTAL GERONTOLOGY
- Imaging niacin trafficking with positron emission tomography reveals in vivo monocarboxylate transporter distribution
- (2020) Salvatore Bongarzone et al. NUCLEAR MEDICINE AND BIOLOGY
- Clinical Evidence for Targeting NAD Therapeutically
- (2020) Dina Radenkovic et al. Pharmaceuticals
- NAD+ metabolism and its roles in cellular processes during ageing
- (2020) Anthony J. Covarrubias et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
- (2019) Lingyan Ye et al. FASEB JOURNAL
- NAD+ metabolism governs the proinflammatory senescence-associated secretome
- (2019) Timothy Nacarelli et al. NATURE CELL BIOLOGY
- Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications
- (2019) Valeria Gasperi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock
- (2019) Kumar Subramani et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- HDL and Reverse Cholesterol Transport
- (2019) Mireille Ouimet et al. CIRCULATION RESEARCH
- Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study
- (2019) Sathish Periyasamy et al. JAMA Psychiatry
- The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases
- (2019) Kelly A. Hogan et al. Frontiers in Immunology
- Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
- (2019) Yasir S. Elhassan et al. Cell Reports
- Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men
- (2019) Ole L. Dollerup et al. JOURNAL OF PHYSIOLOGY-LONDON
- Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
- (2019) Audrey Sambeat et al. Nature Communications
- Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
- (2018) Luis Rajman et al. Cell Metabolism
- DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates
- (2018) David G. McLaren et al. Cell Metabolism
- Raising NAD in Heart Failure
- (2018) Matthew A. Walker et al. CIRCULATION
- Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH
- (2018) Sergiy M. Nadtochiy et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
- (2018) Christopher R. Martens et al. Nature Communications
- Nicotinamide adenine dinucleotide is transported into mammalian mitochondria
- (2018) Antonio Davila et al. eLife
- Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic connexin 43
- (2018) Eun Roh et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Niacin and heart disease prevention: Engraving its tombstone is a mistake
- (2017) Harold Robert Superko et al. Journal of Clinical Lipidology
- The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
- (2017) Arnab Ray Chaudhuri et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondria in the nervous system: From health to disease, Part I
- (2017) Brian M. Polster et al. NEUROCHEMISTRY INTERNATIONAL
- Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
- (2017) Zhiwen Yao et al. NEUROSCIENCE LETTERS
- Mitochondrial function in hypoxic ischemic injury and influence of aging
- (2017) P. Benson Ham et al. PROGRESS IN NEUROBIOLOGY
- Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy
- (2017) Nicolas Diguet et al. CIRCULATION
- Visualization of lipid directed dynamics of perilipin 1 in human primary adipocytes
- (2017) Jesper S. Hansen et al. Scientific Reports
- Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice
- (2016) Natalie E. de Picciotto et al. AGING CELL
- NAD + metabolism: Bioenergetics, signaling and manipulation for therapy
- (2016) Yue Yang et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
- (2016) Kathryn F. Mills et al. Cell Metabolism
- Niacin and Selenium Attenuate Sepsis-Induced Lung Injury by Up-Regulating Nuclear Factor Erythroid 2–Related Factor 2 Signaling*
- (2016) Woon Yong Kwon et al. CRITICAL CARE MEDICINE
- The potential regulatory roles of NAD+ and its metabolism in autophagy
- (2016) Dong-Xia Zhang et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2
- (2016) Emily C. Graff et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
- (2016) Joanna Ratajczak et al. Nature Communications
- Sirtuin regulation in aging and injury
- (2015) Ninu Poulose et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model
- (2015) Aaron N Long et al. BMC Neurology
- NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
- (2015) Carles Cantó et al. Cell Metabolism
- Effect of extended-release niacin on cardiovascular events and kidney function in chronic kidney disease: a post hoc analysis of the AIM-HIGH trial
- (2015) Roberto S. Kalil et al. KIDNEY INTERNATIONAL
- Unknown
- (2015) Ahmar Ayub et al. MOLECULAR MEDICINE
- Physiological and pathophysiological roles of NAMPT and NAD metabolism
- (2015) Antje Garten et al. Nature Reviews Endocrinology
- NAD+ in aging, metabolism, and neurodegeneration
- (2015) E. Verdin SCIENCE
- Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer’s disease-relevant murine model
- (2014) Rosemary A Schuh et al. BMC NEUROSCIENCE
- Senescence and apoptosis: dueling or complementary cell fates?
- (2014) B. G. Childs et al. EMBO REPORTS
- Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog
- (2014) Michael Jaehme et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion
- (2014) Takanobu Yamamoto et al. PLoS One
- NAD+ and sirtuins in aging and disease
- (2014) Shin-ichiro Imai et al. TRENDS IN CELL BIOLOGY
- Recent advances in transport of water-soluble vitamins in organs of the digestive system: a focus on the colon and the pancreas
- (2013) Hamid M. Said AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
- (2013) Laurent Mouchiroud et al. CELL
- GPR109A and Vascular Inflammation
- (2013) Joshua T. Chai et al. Current Atherosclerosis Reports
- Niacin, an old drug with a new twist
- (2013) Wen-Liang Song et al. JOURNAL OF LIPID RESEARCH
- Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
- (2013) Bing Gong et al. NEUROBIOLOGY OF AGING
- A senescent cell bystander effect: senescence-induced senescence
- (2012) Glyn Nelson et al. AGING CELL
- Effect of Extended-Release Niacin on New-Onset Diabetes Among Hyperlipidemic Patients Treated With Ezetimibe/Simvastatin in a Randomized Controlled Trial
- (2012) J. R. Guyton et al. DIABETES CARE
- Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells
- (2012) Lin-Hua Zhang et al. JOURNAL OF LIPID RESEARCH
- Ten metal complexes of vitamin B3/niacin: Spectroscopic, thermal, antibacterial, antifungal, cytotoxicity and antitumor studies of Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Pd(II), Cd(II), Pt(IV) and Au(III) complexes
- (2012) Foziah A. Al-Saif et al. JOURNAL OF MOLECULAR STRUCTURE
- G protein-coupled receptors for energy metabolites as new therapeutic targets
- (2012) Clara C. Blad et al. NATURE REVIEWS DRUG DISCOVERY
- Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession
- (2012) Dong Liu et al. NEUROBIOLOGY OF AGING
- Niacin Lipid Efficacy Is Independent of Both the Niacin Receptor GPR109A and Free Fatty Acid Suppression
- (2012) B. Lauring et al. Science Translational Medicine
- The dynamic regulation of NAD metabolism in mitochondria
- (2012) Liana Roberts Stein et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Niacin in Cardiovascular Disease: Recent Preclinical and Clinical Developments
- (2011) Janet E. Digby et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Intestinal absorption of water-soluble vitamins in health and disease
- (2011) Hamid M. Said BIOCHEMICAL JOURNAL
- Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
- (2011) Jun Yoshino et al. Cell Metabolism
- Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
- (2011) P. W. Caton et al. DIABETOLOGIA
- Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis
- (2011) Shin-ichiro Imai FEBS LETTERS
- Compartmentation of NAD+ -dependent signalling
- (2011) Friedrich Koch-Nolte et al. FEBS LETTERS
- Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells
- (2011) Andrey Nikiforov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unknown
- (2011) Bixi Jian et al. MOLECULAR MEDICINE
- Preventing NAD+ Depletion Protects Neurons against Excitotoxicity
- (2010) Dong Liu et al. Annals of the New York Academy of Sciences
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
- (2010) Riekelt H. Houtkooper et al. ENDOCRINE REVIEWS
- Inhibition of Nicotinamide Phosphoribosyltransferase
- (2010) Maria Pittelli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of Niacin Therapy on Cardiovascular Outcomes in Patients With Coronary Artery Disease
- (2010) Jasleen K. Duggal et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- Nicotinic acid– and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice
- (2010) Julien Hanson et al. JOURNAL OF CLINICAL INVESTIGATION
- Sugar transporters for intercellular exchange and nutrition of pathogens
- (2010) Li-Qing Chen et al. NATURE
- HYPOXIA-INDUCED ALTERATION OF MITOCHONDRIAL GENES IN CARDIOMYOCYTES
- (2010) Bixi Jian et al. SHOCK
- GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon
- (2009) M. Thangaraju et al. CANCER RESEARCH
- Nicotinamide Phosphoribosyltransferase Regulates Cell Survival Through NAD + Synthesis in Cardiac Myocytes
- (2009) Chiao-Po Hsu et al. CIRCULATION RESEARCH
- Nicotinic acid and the prevention of coronary artery disease
- (2009) Janet E Digby et al. CURRENT OPINION IN LIPIDOLOGY
- Niacin and cholesterol: The history of a discovery
- (2009) A. Hoffer Journal of Clinical Lipidology
- GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors
- (2009) Kashan Ahmed et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition
- (2008) Katrina L Bogan et al. Annual Review of Nutrition
- Niacin inhibits surface expression of ATP synthase β chain in HepG2 cells: implications for raising HDL
- (2008) Lin-Hua Zhang et al. JOURNAL OF LIPID RESEARCH
- NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
- (2007) Weihai Ying ANTIOXIDANTS & REDOX SIGNALING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started