Article
Biochemistry & Molecular Biology
Mahalakshmi Pandian, V. Anil Kumar, R. Jayakumar
Summary: The newly developed Cs-Ocd bandage with porous structure, enhanced swelling property, and controlled release of Ocd can significantly reduce skin infections. The bandage exhibits good hemostatic potential, antimicrobial, and anti-biofilm activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Reena Nayak, Biswakanth Kar, Goutam Ghosh, Goutam Rath
Summary: The vagina's unique physical and biological properties make it an ideal site for drug delivery related to women's health issues. Chitosan has received attention for its unique characteristics and is widely studied in vaginal drug delivery systems. However, issues such as chitosan's susceptibility to the acidic pH of the vagina, poor drug loading, and rapid mucosal turnover need to be addressed for successful outcomes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Dazhong Yan, Yanzhen Li, Yinling Liu, Na Li, Xue Zhang, Chen Yan
Summary: Chitosan, a natural antimicrobial polymer, has potential as an alternative for antibiotics in therapy and disinfection due to its ability to kill microbes by neutralizing their negative charges on the surface. Chemically modified chitosan derivatives have better water solubility and antimicrobial properties, offering promise for improvement in the treatment of enteric infections.
Review
Chemistry, Applied
Somaye Rashki, Kasra Asgarpour, Hossein Tarrahimofrad, Maryam Hashemipour, Mohammad Saeid Ebrahimi, Hadis Fathizadeh, Ahmad Khorshidi, Haroon Khan, Zeynab Marzhoseyni, Masoud Salavati-Niasari, Hamed Mirzaei
Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.
CARBOHYDRATE POLYMERS
(2021)
Article
Infectious Diseases
Maria Lajarin-Reinares, Eloy Pena-Rodriguez, Mariona Canellas-Santos, Elisabet Rosell-Vives, Pilar Cortes, Montserrat Llagostera Casas, Maria Angels Calvo, Francisco Fernandez-Campos
Summary: Topically applied antimicrobial drugs have several advantages, but the widespread use of antibiotics has led to increasing antimicrobial resistance. Drug repurposing, such as with disulfiram, may provide an attractive alternative for treating multidrug-resistant bacteria in skin infections.
Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Article
Polymer Science
Henry Chijcheapaza-Flores, Nicolas Tabary, Feng Chai, Mickael Maton, Jean-Noel Staelens, Frederic Cazaux, Christel Neut, Bernard Martel, Nicolas Blanchemain, Maria Jose Garcia-Fernandez
Summary: This study aims to combine the properties of hydrogels based on chitosan (CHT) and the polymer of beta cyclodextrin (PCD) for local delivery of cinnamaldehyde (CN) in diabetic foot ulcers. The results demonstrated the successful development of a cytocompatible (ISO 10993-5) injectable hydrogel with antibacterial and antibiofilm activity. Furthermore, a partial active molecule release and an increase in hydrogel elasticity were observed in the presence of CN.
Article
Biochemistry & Molecular Biology
Rimpy Pahwa, Munish Ahuja
Summary: The objective of this study was to develop a vaginal drug delivery system using lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked with trisodium trimetaphosphate. The optimal formulation of the cross-linked rice or wheat nanocellulose-gellan based scaffolds contained specific concentrations of polymers and cross-linking agents. The cross-linked scaffolds exhibited higher thermal stability, porosity, tensile strength, and mucoadhesive strength, and slower enzymatic degradation. They also provided sustained release of fluconazole and increased vaginal permeation compared to non cross-linked scaffolds. Additionally, the phosphorylated nanocellulose-gellan based scaffolds showed improved antifungal activity and non-cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
J. B. M. Rocha Neto, G. G. Lima, A. Fiamingo, L. G. L. Germiniani, T. B. Taketa, R. A. Bataglioli, G. A. T. da Silveira, J. V. L. da Silva, S. P. Campana-Filho, O. N. Oliveira Jr, M. M. Beppu
Summary: By adjusting the degree of deacetylation of chitosans and the pH of the solution, the properties of HA/CHI LbL films can be controlled, providing tailored film materials for various applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Asma Sharkawy, Ana Margarida Silva, Francisca Rodrigues, Filomena Barreiro, Alirio Rodrigues
Summary: The study evaluated chitosan/collagen peptides nanoparticles-stabilized Pickering emulsions as an effective carrier for the topical delivery of cannabidiol. Among them, olive oil-prepared emulsion showed good stability and long-term storage ability, which is beneficial for the topical delivery of CBD.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Biochemistry & Molecular Biology
R. Bharathi, S. Shree Ganesh, G. Harini, Kumari Vatsala, R. Anushikaa, S. Aravind, S. Abinaya, N. Selvamurugan
Summary: The bone tissue engineering approach becomes necessary for treating large bone defects when the tissue damage exceeds the body's inherent regenerative ability. Chitosan is a promising bone scaffold material that supports cell attachment, proliferation, and mineralization of the bone matrix. Smart drug delivery scaffolds based on chitosan have been developed to respond to environmental stimuli and provide localized sustained drug delivery in the area of large bone defects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Medicine, Research & Experimental
Mingyue Cui, Christian Wiraja, Sharon Wan Ting Chew, Chenjie Xu
Summary: Topical drug delivery has advantages over other routes, but the stratum corneum poses a challenge. Nanotechnology offers opportunities to overcome this challenge with nanocarriers like liposomes and nanoparticles. These formulations show potential in treating skin disorders, with further developments needed.
MOLECULAR PHARMACEUTICS
(2021)
Review
Microbiology
Francesca Bugli, Cecilia Martini, Maura Di Vito, Margherita Cacaci, Daniele Catalucci, Alessandro Gori, Michele Iafisco, Maurizio Sanguinetti, Alberto Vitali
Summary: Antibiotic resistance is a major global health and social issue that will have significant repercussions on world health and the economy in the near future. To address this, researchers in medical, microbiological, and biochemical fields are exploring the potential of antimicrobial peptides (AMPs) as an alternative to conventional drugs. This review focuses on the application of AMPs in the specific context of cystic fibrosis (CF), highlighting different types of natural, naturally modified, and synthetic peptides, as well as strategies to overcome barriers and adapt to physiological conditions.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zhishu Bao, Ailing Yu, Hui Shi, Yuhan Hu, Bo Jin, Dan Lin, Mali Dai, Lei Lei, Xingyi Li, Yuqin Wang
Summary: In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Sabrina Valetti, Hanna Thomsen, Jitendra Wankar, Peter Falkman, Ilse Manet, Adam Feiler, Marica B. Ericson, Johan Engblom
Summary: Research has shown that porous particles of appropriate size and porosity can accumulate in hair follicles and furrows on the skin, providing a potential area for drug delivery. The combination of follicle orifices and furrows can cover up to 20% of the skin surface, making them valuable for optimizing bioavailability of topical formulations. This work highlights the potential of skin furrows for topical drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Natasa Skalko-Basnet, Ganesh Acharya, Purusotam Basnet
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2015)
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Purusotam Basnet, Ganesh Acharya, Natasa Salko-Basnet
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2017)
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Zeljka Vanic, Ingunn Tho, Natasa Skalko-Basnet
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2014)
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Purusotam Basnet, Mia Jonine Tostrup, Sabrin Moueffaq, Natasa Skalko-Basnet
Article
Chemistry, Medicinal
May Wenche Joraholmen, Abhilasha Bhargava, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Mona Johannessen, Kirsten Gravningen, Mirja Puolakkainen, Ganesh Acharya, Purusotam Basnet, Natasa Skalko-Basnet
Article
Chemistry, Medicinal
Lisa Myrseth Hemmingsen, Kjersti Julin, Luqman Ahsan, Purusotam Basnet, Mona Johannessen, Natasa Skalko-Basnet
Summary: In an era of antimicrobial resistance, novel treatment options are urgently needed to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing. Tailoring formulations for acute skin injuries is crucial for proper skin retention and release of antimicrobials.
Review
Pharmacology & Pharmacy
Zeljka Vanic, May Wenche Joraholmen, Natas Skalko-Basnet
Summary: There has been a surprising increase in sexually transmitted infections (STIs) in recent years, coupled with the threat of rising antimicrobial resistance (AMR). The use of nano medicine for treating vaginal infections offers advantages such as localized therapy, reducing systemic drug exposure, and minimizing side effects.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Applied
Lisa Myrseth Hemmingsen, Barbara Giordani, Ann Kristin Pettersen, Beatrice Vitali, Purusotam Basnet, Natasa Skalko-Basnet
Summary: The incorporation of chlorhexidine (CHX) liposomes into chitosan hydrogel significantly enhances its antimicrobial activity, leading to effective eradication of bacteria and biofilms, with potential therapeutic applications for skin infections.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Pauliina Damdimopoulou, Ganesh Acharya, Natasa Skalko-Basnet
Summary: A formulation using liposomes loaded with resveratrol (RES) and incorporated into a chitosan hydrogel has been developed for delivering RES to the vaginal site. In vitro experiments showed that this formulation is non-irritant and biocompatible with vaginal tissue at therapeutic concentrations.
Article
Microbiology
Lisa Myrseth Hemmingsen, Pimmat Panchai, Kjersti Julin, Purusotam Basnet, Mona Nystad, Mona Johannessen, Natasa Skalko-Basnet
Summary: Infected chronic skin wounds and other skin infections are becoming a growing concern due to the rise of antimicrobial resistance and biofilm-producing bacteria. In this study, the researchers aimed to investigate the potential of chitosan-containing and chitosan-coated liposomes as a delivery system for the membrane-active antimicrobial chlorhexidine to infected wounds. The results showed that the vesicles comprising chitosan had a slower release rate of chlorhexidine and high cell compatibility. Additionally, the vesicles reduced the inflammatory responses in macrophages and demonstrated strong antibacterial effects against Staphylococcus aureus. These findings suggest that chitosan-containing and chitosan-coated liposomes could serve as excellent platforms for delivering membrane-active antimicrobials to infected wounds.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Materials Science, Biomaterials
Lisa Myrseth Hemmingsen, Barbara Giordani, Marianne H. Paulsen, Zeljka Vanic, Goril Eide Flaten, Beatrice Vitali, Purusotam Basnet, Annette Bayer, Morten B. Strom, Natasa Skalko-Basnet
Summary: The eradication of bacteria in biofilms is a major challenge in treating chronic wounds. Antimicrobial peptides and their mimics are potential options, but their clinical use is limited. A study explored the use of a synthetic mimic of an antimicrobial peptide incorporated into liposomes to improve its anti-biofilm effect and anti-inflammatory activity. The results showed that the liposomes effectively eradicated biofilms and reduced inflammation, making them a promising therapeutic option for bacteria-infected chronic wounds.
BIOMATERIALS ADVANCES
(2023)
