Article
Biochemistry & Molecular Biology
Seyedeh Sara Ashraf, Kazem Parivar, Nasim Hayati Roodbari, Shohre Mashayekhan, Naser Amini
Summary: This study aimed to fabricate and characterize a nanofiber skin substitute with enhanced mechanical properties and cellular compatibility. The scaffold consisted of collagen, sodium alginate, and exopolysaccharides produced by Rhodotorula mucilaginosa sp. GUMS16. The cross-linked nanofibers were characterized and tested for cell viability and proliferation. The results showed that the incorporation of GUMS16-produced exopolysaccharides increased cell viability and proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Dermatology
Fatma Kubra Tombulturk, Tugba Soydas, Gonul Kanigur-Sultuybek
Summary: The wound healing process is interrupted in diabetes due to high blood sugar levels. The aim of this study is to investigate the effects of metformin on wound healing in diabetic and non-diabetic wounds. The results showed that metformin increased cellular proliferation, decreased apoptosis, and improved collagen synthesis in both diabetic and non-diabetic wounds. Overall, the topical application of metformin on diabetic wounds reversed the adverse effects of diabetes and improved the wound healing process.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Integrative & Complementary Medicine
Davood Nasiry, Ali Reza Khalatbary, Alireza Ghaemi, Mohammad Ali Ebrahimzadeh, Mohammad Hossein Hosseinzadeh
Summary: This study demonstrates that topical administration of Juglans regia L. leaf extract significantly accelerates diabetic wound healing, especially at a concentration of 5%.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Manon Barthe, Lionel Gillot, Laurie Perdigon, Aline Jacobs, Gregory Schoonbroodt, Paul Mauhin, Emna Bouhajja, Hanan Osman-Ponchet
Summary: This study investigated the potential of a non-medicinal topical cocktail of probiotic bacteria in promoting wound healing in dogs. The results showed that the probiotic combination promoted cell migration and wound closure, but further experiments are needed to confirm and validate these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Seulgi Kim, Jina Ko, Jae Hyuk Choi, Jeong Yi Kang, Chanoong Lim, Mikyung Shin, Dong Woog Lee, Jin Woong Kim
Summary: A new skin tissue adhesive system has been developed using antigen-antibody interaction, which effectively adheres to the skin surface and promotes wound healing. This system could pave the way for developing a new type of tissue adhesive for skin tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Mohammed S. Algahtani, Mohammad Zaki Ahmad, Ibrahim Ahmed Shaikh, Basel A. Abdel-Wahab, Ihab Hamed Nourein, Javed Ahmad
Summary: Thymoquinone, a natural bioactive substance with therapeutic activity against multiple ailments, was incorporated into a nanoemulsion-based hydrogel system to enhance its topical efficacy in wound healing. The use of black seed oil improved the drug loading capacity and reduced oil droplet size, resulting in enhanced skin penetrability and deposition characteristics after topical administration. The nanoemulgel system demonstrated quicker and early healing in wounded rats compared to conventional hydrogel systems, showing comparable efficacy with marketed cream containing silver sulfadiazine.
Article
Dermatology
Danielle Cristina Garbuio, Marcel Nani Leite, Sonia Aparecida Figueiredo, Luis Alexandre Pedro De Freitas, Emilia Campos De Carvalho, Marco Andrey Cipriani Frade
Summary: The objective of this study was to evaluate the efficacy of a topical formulation containing chitosan-chamomile microparticles in cutaneous healing in rats. Male Wistar rats were randomly divided into three groups: treatment, vehicle, and control. Evaluations were conducted on days 2, 7, and 14 after the surgical procedure. The results showed that the formulation improved the quality of cicatricial tissue formed with a greater quantity of fibroblasts and collagen.
JOURNAL OF WOUND CARE
(2023)
Article
Chemistry, Multidisciplinary
Lu Liu, Ran Li, Fei Liu, Liqian Huang, Wanshuang Liu, Juan Wang, Zhenkai Wu, Narendra Reddy, Wenguo Cui, Qiuran Jiang
Summary: Due to the lack of elasticity and strain sensing capability, protein-based ultrafine fibrous tissue engineering scaffolds cannot monitor wound during healing. In this study, we designed highly elastic corn protein ultrafine fibrous smart scaffolds with a three-layer structure for motion tracking. The protein fibers had wide-range stretchability and ultrahigh elasticity at a wet state, and the scaffolds were equipped with a silver conductive sensing layer for strain sensing. These smart scaffolds could support cell growth, accelerate wound closure, track motions on skin and in vivo, and trigger alarms for excessive wound deformations. This research demonstrates the potential of smart scaffolds for tissue reconstruction and wound monitoring.
Review
Biochemistry & Molecular Biology
Zhaoming Deng, Jun Liang, Na Fang, Xiangwei Li
Summary: Dental implants are widely accepted due to their mechanical properties and aesthetic outcomes. Successful osseointegration and tight soft tissue integration, particularly collagen fibers in the transmucosal region, contribute to their restorative success. Surface modification methods can enhance soft tissue integration. This review focuses on the differences in the transmucosal zone around dental implants compared to natural teeth and explores the latest strategies for enhancing soft tissue integration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Harshad S. Kapare, Prabhanjan S. Giram, Sadhana S. Raut, Hemant K. Gaikwad, Ana Claudia Paiva-Santos
Summary: Flavonoids and polyphenolic compounds found in propolis, a natural bee product, play a crucial role in wound healing. This study aimed to develop and characterize a propolis-based hydrogel composition with wound healing potential. The formulation was analyzed for its phytochemical content, pH, viscosity, and in vitro release. Results from burn and excision wound healing models demonstrated the efficacy of the propolis hydrogel in promoting wound contraction and re-epithelialization, comparable to the standard povidone iodine ointment. This formulation shows promise for further clinical research on wound healing.
Article
Pharmacology & Pharmacy
Yuan-Shuo Hsueh, Yan-Jye Shyong, Hsiu-Ching Yu, Shu-Jhen Jheng, Shang-Wen Lin, Hua-Lin Wu, Jui-Chen Tsai
Summary: The study developed NLC formulations containing rhTM, which effectively promoted chronic wound healing with high encapsulation efficiency and sustained release. In diabetic mouse models, it showed significant improvement in wound healing and cell migration, with lower plasma concentrations compared to rhTM solution.
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dermatology
Jack Dunn, Yi Liu, Fabiana Banov, Sebastian Denison, Daniel Banov
Summary: This case study demonstrated the effectiveness of a compounded topical formulation containing naltrexone in managing surgical wound, showing accelerated wound healing and prevention of abnormal scarring.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Tanmay S. Markandeywar, Raj Kumar Narang, Dilpreet Singh, Vineet Kumar Rai
Summary: Cancer is a major cause of death globally, particularly brain cancer, colon cancer, and breast cancer which are considered fatal. Doxorubicin is a commonly used drug for various types of cancer, but its effectiveness is hindered by poor solubility, permeability, and in vivo fate. A multifunctional nanocarrier could improve drug delivery and reduce side effects by targeting cancer sites. This review focuses on enhancing the targetability of doxorubicin using nanocarriers and discusses the challenges and prospects for improved drug delivery and therapeutic outcomes.
CURRENT DRUG DELIVERY
(2023)
Article
Chemistry, Physical
Sushri Sangita Nanda, Priyanka Nayak, Sasank Pattnaik, Vineet Kumar Rai, S. Dash
Summary: A series of xMg2+/ySc3+ co-doped beta-NaYF4:0.2Yb3+/0.02Ho3+ upconversion green phosphors were synthesized using EDTA-assisted hydrothermal method. The structure, morphology, and elemental compositions were investigated, and the co-doping effect on the green emission was studied. The temperature sensing performance and color purity of the phosphors were also discussed, showing their potential applications in temperature sensors and LEDs.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Biochemistry & Molecular Biology
Prativa Biswasroy, Deepak Pradhan, Dipak Kumar Sahu, Vineet Rai, Jitu Halder, Tushar Kanti Rajwar, Rajesh Kumar Bhola, Biswakanth Kar, Goutam Ghosh, Goutam Rath
Summary: In this study, the potential therapeutic effect of the natural molecule BE extracted from Betula utilis on psoriasis was evaluated in vitro and in vivo. Computational analysis demonstrated the high affinity of BE towards pro-inflammatory cytokines and overexpressed receptors. Experimental results showed that BE exhibited anti-inflammatory and histological recovery effects in a psoriasis-like inflammation model.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Engineering, Biomedical
Keisham Nelson Mangang, Pragati Thakran, Jitu Halder, Kuldeep Singh Yadav, Goutam Ghosh, Deepak Pradhan, Goutam Rath, Vineet Kumar Rai
Summary: Microneedle arrays are micron-sized needles used for drug delivery, and Polyvinylpyrrolidone (PVP) has been widely utilized as a carrier for delivering biologics transdermally. However, its non-biodegradability raises concerns regarding its presence in the body post-treatment. This review analyzes the advancements and applications of PVP microneedles in drug delivery systems and cosmetology, as well as its biodegradation properties and pharmaceutical uses.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Pharmacology & Pharmacy
Vineet Kumar Rai, Ivy Saha, Mahboob Alam, Kumar Nishchaya, Goutam Ghosh, Goutam Rath
Summary: The passive transport of drug molecules through human skin has limitations, resulting in the development of novel means, such as microneedles, for delivering larger molecules. Microneedles have been extensively studied for their applications in chemotherapy, dermatology, metabolic disorders, and neuro-disorders. This article highlights the trends and recent advancements of microneedles, including their fabrication technologies, preferred types, and materials, as well as their compatibility for drug delivery in various fields, such as chemotherapy, vaccination, and diagnosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tushar Kanti Rajwar, Deepak Pradhan, Jitu Halder, Vineet Kumar Rai, Biswakanth Kar, Goutam Ghosh, Goutam Rath
Summary: Malaria is a life-threatening parasitic disease transmitted by the infected female Anopheles mosquito. Nanotechnology-based drug delivery systems have shown promise in improving the efficacy and reducing toxicity of antimalarial therapeutics. These systems enhance drug properties and target delivery to specific sites, reducing the risk of drug resistance and improving clinical outcomes.
JOURNAL OF DRUG TARGETING
(2023)
Review
Pharmacology & Pharmacy
Sudhanshu Ranjan Rout, Biswakanth Kar, Deepak Pradhan, Prativa Biswasroy, Jitu Haldar, Tushar Kanti Rajwar, Manoj Kumar Sarangi, Vineet Kumar Rai, Goutam Ghosh, Goutam Rath
Summary: Oral mucositis is a serious problem for patients undergoing cancer treatment. Currently available mucosal protectants have poor efficacy due to retention issues, lack of lubrication, biodegradability problems, and inability to manage secondary complications. Chitosan, with its beneficial biomedical properties, including anti-inflammatory and anti-microbial abilities, as well as its capability to scavenge free radicals, is a promising material for treating oral mucositis. This article summarizes the key biological properties of chitosan and its derivatives for the treatment of oral mucositis, showing that chitosan has superior mucosal protective properties when used alone or as a drug delivery system.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Biswakanth Kar, Deepak Pradhan, Jitu Halder, Vineet Kumar Rai, Goutam Ghosh, Goutam Rath
Summary: Viral diseases have a significant impact on economic losses and pose a threat to societies worldwide. Conventional formulations face challenges in effectively targeting specific cells due to high mutation rates. This review explores the role of carbohydrate polymers in preventing and treating viral infections, their sources, molecular characteristics, and the mechanisms by which they improve the properties of antiviral drugs.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Materials Science, Ceramics
Vishab Kesarwani, Vineet Kumar Rai
Summary: Bismuth modified Er3+/Yb3+: TeO2-WO3 (TWBi) glass system containing silver metallic nanoparticles have been synthesized and analyzed for optical bandgap and Judd-Ofelt parameters. The presence of silver metallic nano-particles (AgNPs) in the glass was confirmed by HR-TEM analysis. The inclusion of AgNPs improved the upconversion emission intensity and temperature sensitivity of the glass.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Materials Science, Multidisciplinary
Manisha Prasad, Vineet Kumar Rai
Summary: The tunability of upconversion emission was achieved by varying dopant concentration and optimized in the cyan emitting region. Optical bistability was observed in Tm3+/Yb3+: MgWO4 phosphors. The CIE coordinates shifted towards the green region upon Er3+ doping. Decay curve analysis was performed for the developed phosphors. The optical thermometry using the fluorescence intensity ratio (FIR) approach considered the thermally and non-thermally coupled levels of Er3+ and Tm3+ ions in the coactivated MgWO4 phosphors. The addition of Er3+ and Li+ improved the sensitivity of luminescence thermometry in Tm3+/Yb3+: MgWO4 phosphors, with higher sensitivity observed in the non-thermally coupled levels compared to the thermally coupled levels.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Optics
Priyanka Nayak, Sushri Sangita Nanda, Sasank Pattnaik, Vineet Kumar Rai, R. K. Sharma, S. Dash
Summary: Upconversion emission of CaWO4:Er3+/Yb3+/Mn2+ phosphor synthesized via ethylene glycol route under 980 nm diode laser excitation is analyzed. Structural information, morphology, and the energy transfer mechanism with Yb-Mn dimer are studied. Optical thermometric performance based on the thermally coupled green levels of Er3+ ions and the internal heating characteristics are explored. The prepared phosphors exhibit strong green emission and high color purity under 980 nm excitation.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Vineet Kumar Rai, Ankita Roy, Alok Sharma, Goutam Rath, Biswakanth Kar, Goutam Ghosh, Deepak Pradhan, Jitu Halder
Summary: This study developed and evaluated a lipid nanoemulsion-based gel with azelaic acid and tacrolimus, which showed improved drug availability and efficacy against plaque psoriasis.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Pharmacology & Pharmacy
Jitu Halder, Tushar Kanti Rajwar, Deepak Pradhan, Vineet Kumar Rai, Debasmita Dubey, Biswakanth Kar, Goutam Ghosh, Goutam Rath
Summary: By designing and optimizing a multifunctional Glycyrrhizin-loaded Hyaluronic acid (HA) nanofiber-based artificial saliva, this study aims to effectively manage chemotherapy-induced oral mucositis (OM) while providing benefits against inflammatory and infectious conditions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Analytical
Megha Garg, Neha Jain, Shreya Kaul, Vineet Kumar Rai, Upendra Nagaich
Summary: Microneedle (MN) technology is important in bioengineering for minimally invasive exposure to the skin, increased drug permeability, and improved biological molecule detectability. However, MNs have drawbacks such as difficulty scaling up, variability in drug delivery pattern, tissue blockage, and inflammatory response. Despite these, MNs are a unique tool in diagnostics and therapeutics, crossing the stratum corneum to measure analytes. This review discusses recent advances, diagnostics challenges, clinical state, and commercial accessibility of MN technology-based devices.
Article
Chemistry, Multidisciplinary
Manisha Prasad, Vineet Kumar Rai
Summary: The structural and optical properties of Er3+/Yb3+/Mo6+-codoped aurivillius-structured Bi2WO6 phosphors were studied. Codoping Yb3+ and Mo6+ ions enhanced the green emission in Er3+:Bi2WO6 phosphors. The energy transfer from Yb3+-MoO42- dimers to Er3+ ions was responsible for the enhancement. The rate equations were used to discuss the luminescence saturation processes. The H-2(11/2) and S-4(3/2) energy levels of Er3+ ions were suitable for optical thermometry. The thermal stability was verified with the Arrhenius equation.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
