Review
Dermatology
Shereen Teymour, Barbara Kania, Karan Lal, David Goldberg
Summary: This study reviewed the safety and efficacy of energy-based devices (ablative lasers, non-ablative lasers, and radiofrequency microneedling) for treating acne scarring in skin phototypes IV-VI. The results showed that both ablative and non-ablative lasers have proven to be effective, with the latter being safer for skin of color. Limited studies on radiofrequency microneedling have shown promising results. Further research is needed to evaluate the efficacy and safety in darker skin phototypes V-VI.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Mario Galletti, Maria Pia Anania, Sahar Arjmand, Angelo Biagioni, Gemma Costa, Martina Del Giorno, Massimo Ferrario, Valerio Lollo, Riccardo Pompili, Yoav Raz, Vladimir Shpakov, Fabio Villa, Arie Zigler, Alessandro Cianchi
Summary: In this Letter, the authors describe an experimental campaign using a gas-filled discharge-capillary to stabilize plasma generation in compact plasma-based accelerators. They demonstrate efficient stabilization of discharge pulse and plasma density using pre-ionizing methods, enabling the development of longer capillaries and longer acceleration lengths for plasma-based acceleration experiments.
Article
Dermatology
Ye-Jin Lee, Chan-Yang Lee, Min Kyung Shin
Summary: This study found that among 416 patients with acne scars, 98.56% had atrophic scars, 12.74% had keloid scars, and 11.06% had papular acne scars. Histologic analysis showed fibrotic tissue in both keloid and papular acne scars, with fibrosis of the papular scar limited to the upper dermis.
DERMATOLOGIC SURGERY
(2021)
Review
Engineering, Biomedical
Nastaran Sarvipour, Zahra Akbari, Mohammad Shafie'ei, Marzieh Jamali, Mohadese Ahmadzade, Najmeh Ahramiyanpour
Summary: Scarring after inflammatory acne is aesthetically challenging and psychologically burdensome. In this review, we evaluated the efficacy of laser therapy for managing acne scars and found that various types of lasers were highly effective in improving skin color and elasticity, with minimal and transient adverse events.
LASERS IN MEDICAL SCIENCE
(2022)
Editorial Material
Obstetrics & Gynecology
Julia Pakey, Janelle S. Nassim, Rachel Reynolds
Summary: Counseling patients about the risk of acne associated with hormonal intrauterine devices is crucial in shared decision making for contraception methods.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Dermatology
Dong Hyo Kim, Ji Hoon Yang, Soo Ick Cho, Ji Young Yoon, Ji Won Kim, Sungjun Choi, Dae Hun Suh
Summary: The clinical efficacy of epidermal growth factor ointment (EGFO) on acne and acne scars was evaluated in this study. The results indicated that EGFO significantly improved acne lesions and scars. Treatment with EGFO altered the expression of various factors related to acne and scarring.
Article
Dermatology
Jing Li, Fangfang Duan, Jie Kuang
Summary: Fractional radiofrequency (FRF) treatment is more effective than lasers in improving patient-evaluated acne and is as effective as lasers in treating atrophic acne scars. FRF has a lower incidence of post-inflammatory hyperpigmentation (PIH) and shorter duration of erythema compared to lasers. FRF could be a better choice for atrophic acne scar patients with active acne and those prone to pigmentation.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Yasmina ElAttar, Basma Mourad, Hebat-Allah Alngomy, Aliaa Shams El Deen, Mayada Ismail
Summary: This study found a significant increase in the expression of interleukin-1 beta (IL-1 beta) in acne vulgaris and acne scars, which was closely correlated with the clinical and histopathological severity of acne vulgaris. This suggests that IL-1 beta may play a key role in the pathogenesis of acne and the development of acne scars.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Dermatology
Chingshubam Bikash, Rashmi Sarkar
Summary: Scarring is a common and challenging consequence of acne vulgaris. Current treatments for acne scars mainly rely on invasive, non-topical modalities which may not be suitable for all patients. This review discusses the potential use of topical agents and assisted technology for the treatment of acne scars. While these methods have shown some promise in improving acne scars, there is still a lack of evidence to support their widespread use, highlighting the need for further well-designed studies.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Jerry Tan, Stefan Beissert, Fran Cook-Bolden, Rajeev Chavda, Julie Harper, Adelaide Hebert, Edward Lain, Alison Layton, Marco Rocha, Jonathan Weiss, Brigitte Dreno
Summary: Acne scars have a significant impact on patients' health-related quality of life, with even mild scars leading to a noticeable decrease in quality of life that increases with the severity of scarring. Individual-reported outcomes offer insight into the physical, functional, and psychological impact of acne scarring from the patient's perspective.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Article
Dermatology
Lin Liu, Yuzhou Xue, Yangmei Chen, Tingqiao Chen, Judan Zhong, Xinyi Shao, Jin Chen
Summary: This study aimed to assess the global prevalence and risk factors of acne scars in patients with acne. A systematic search of published studies was conducted and 37 studies involving 24,649 acne patients were included. The study found that 47% of acne patients suffered from acne scars and identified three risk factors: male gender, positive family history of acne, and acne severity.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Review
Medicine, General & Internal
Karolina Chilicka, Monika Rusztowicz, Renata Szygula, Danuta Nowicka
Summary: Acne vulgaris is a common chronic skin disease that can lead to the formation of atrophic scars if not treated properly. There are three types of atrophic scars and multiple effective methods to improve them, such as lasers, radiofrequency, and chemical peels.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Dermatology
Yolanka Lobo, Davin S. Lim
Summary: This study reviewed the instrumentation used for subcision of acne scars and provided practical information on selecting instruments for clinicians, focusing on their advantages and disadvantages. The results showed that sharp, blunt, and energy-assisted instruments were all effective in treating atrophic acne scars.
DERMATOLOGIC SURGERY
(2023)
Article
Dermatology
Cong Sun, Davin Lim
Summary: The study demonstrates that the focal application of 90% TCA with a brush applicator is safe and effective in treating boxcar and polymorphic acne scars, yielding good to excellent clinical outcomes with low complication rates.
DERMATOLOGIC SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Zhaohui Wang, Yong-Hyeok Lee, Sang-Woo Kim, Ji-Young Seo, Sang-Young Lee, Leif Nyholm
Summary: Recent research shows that cellulose can be used to create stable electrochemical energy storage devices with high energy and power densities. Attention should be paid to the properties of cellulose, and it is suitable for large-scale production.
ADVANCED MATERIALS
(2021)
Article
Dermatology
Meghan Seago, Peter R. Shumaker, Leah K. Spring, Murad Alam, Firas Al-Niaimi, R. Rox Anderson, Ofir Artzi, Ardeshir Bayat, Daniel Cassuto, Henry H. L. Chan, Christine Dierickx, Matthias Donelan, Gerd G. Gauglitz, Boncheol Leo Goo, Greg J. Goodman, Geoffrey Gurtner, Merete Haedersdal, Andrew C. Krakowski, Woraphong Manuskiatti, William B. Norbury, Rei Ogawa, David M. Ozog, Uwe Paasch, E. Victor Ross, Matteo Tretti Clementoni, Jill Waibel
LASERS IN SURGERY AND MEDICINE
(2020)
Article
Dermatology
Sara Ud-Din, Ardeshir Bayat
Summary: Skin scarring is a complex phenomenon with significant variability in scar type and treatment response among individuals. This study proposes distinct scar endotypes characterized by specific pathology, including Stretched, Contracted, Atrophic, and Raised scarring. A structured approach to evaluating scar parameters is presented to enhance personalized treatment outcomes and further understanding of skin scarring pathophysiology.
ADVANCES IN WOUND CARE
(2022)
Article
Dermatology
Sara Ud-Din, Ardeshir Bayat
Summary: Evaluation and objective scar assessment pre- and post-therapy are crucial for identifying changes in scar characteristics. Emerging noninvasive devices assessing specific scar parameters are being developed, but there is a need for more objective quantitative measures to monitor scar maturation and response to therapy. Validation of these tools and further development of technologies are essential for providing customized strategies for each patient.
ADVANCES IN WOUND CARE
(2022)
Article
Pharmacology & Pharmacy
Sara Ud-Din, Traci A. Wilgus, Douglas D. McGeorge, Ardeshir Bayat
Summary: The study demonstrates that pre-emptive priming of skin before surgery can significantly improve surgically induced skin scarring, including reducing mast cells, blood flow and angiogenesis, and increasing elastin content.
Review
Pharmacology & Pharmacy
Leyla Norouzi-Barough, Ardeshir Bayat
Summary: Validation of potential drug targets is crucial in discovering and developing new therapies for dermal fibrotic conditions like keloid disease. Integration of multi-omics data with traditional and modern technological approaches offers unique opportunities for identifying and validating novel targets in the early stages of drug development.
DRUG DISCOVERY TODAY
(2021)
Article
Dermatology
Dennias Tonderai Nyika, Nonhlanhla P. Khumalo, Ardeshir Bayat
Summary: Advancements in research on the genetic and epigenetic mechanisms involved in keloids have expanded our understanding of the pathobiology of keloids. Studies targeting epigenetic and genetic markers in keloid tissue are being conducted to identify the pathways underlying the initiation and maintenance of keloids.
ADVANCES IN WOUND CARE
(2022)
Article
Medicine, General & Internal
Lisa DiNatale, Jolanta Idkowiak-Baldys, Young Zhuang, Anthony Gonzalez, Thomas J. Stephens, Lily Jiang, Weiping Li, Rubinder Basson, Ardeshir Bayat
Summary: This study systematically demonstrated that rotating the use of known antiaging ingredients can maximize pro-collagen I production, showing better efficacy in improving facial photoaging compared to using each active ingredient alone. Rotation with retinol and phytol/glycolic acid (PGA) proved to be more effective, with confirmed penetration of active ingredients and superior results in clinical trials.
FRONTIERS IN MEDICINE
(2021)
Review
Dermatology
Lia M. G. Neves, Traci A. Wilgus, Ardeshir Bayat
Summary: The process of skin repair results in different types of scarring, which poses a challenge for researchers. The development of experimental models has allowed for the study of variables that influence scar formation. Recent advances in in vitro, ex vivo, and in vivo models have been successful in reproducing scar formation and elucidating its mechanisms.
ADVANCES IN WOUND CARE
(2023)
Article
Immunology
Sara Ud-Din, Ardeshir Bayat
Summary: Inflammation plays a crucial role in wound healing and is directly associated with the extent of injury and subsequent scarring. High levels of inflammation are linked to excessive scarring. Targeting inflammation in scar therapy, especially through early intervention, is important for preventing poor scar outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Rubinder Basson, Ardeshir Bayat
Summary: Although skin scarring is a common consequence of skin injury, it can cause discomfort and psychological distress. Defining and managing scars effectively remains a challenge. Non-invasive treatments are the most accessible, but only a portion of them have shown positive outcomes in studies. Invasive treatments are only used in specific cases, usually as a last resort.
FRONTIERS IN MEDICINE
(2022)
Review
Dermatology
Elvis Banboye Kidzeru, Maribanyana Lebeko, Jyoti Rajan Sharma, Lucia Nkengazong, Henry Ademola Adeola, Hlumani Ndlovu, Nonhlanhla Khumalo, Ardeshir Bayat
Summary: This article discusses the importance of immune factors in the pathogenesis of raised dermal scarring, presents immune cells and associated molecular markers associated with dermal fibrosis, and proposes the potential of immune-modulated therapy in the management of raised dermal scarring.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Engineering, Biomedical
Fatemeh Tavakoli Foroushani, Kevin Dzobo, Nonhlanhla P. Khumalo, Vanessa Zamora Mora, Roberto de Mezerville, Ardeshir Bayat
Summary: This review summarizes recent advances in breast implant surface technologies, including modifications of implant surfaces and their effects on cell-surface interactions. The properties of silicone breast implants impacting cell-material interactions are discussed, as well as recent studies aiming to enhance biocompatibility and prevent complications.
BIOMATERIALS RESEARCH
(2022)
Review
Emergency Medicine
Motaharesadat Hosseini, Jason Brown, Kiarash Khosrotehrani, Ardeshir Bayat, Abbas Shafiee
Summary: This study investigates the mechanical behavior and cellular mechanisms of scar formation, as well as the role of mechanical therapy in scar treatment. Understanding the response of skin cells and the differentiation of myofibroblasts can lead to the development of new scar therapies. Current treatment strategies have limited effectiveness, and optimal scar formation requires a combination of mechanical forces and biochemical signals.