期刊
KIDNEY INTERNATIONAL
卷 101, 期 4, 页码 804-813出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2021.12.014
关键词
chronic kidney disease; magnetic resonance imaging (MRI); prognostic tool
资金
- Clinical Research Center of the Medicine Faculty of Geneva University
- Geneva University Hospital
- Leenards foundation
- Louis-Jeantet foundation
- Swiss National Foundation [32003B_159714, IZCOZO_177140/1, PP00P3_127454, 326030_150816]
- Centre for Biomedical Imaging of EPFL, University of Geneva
- University Hospital of Geneva
- University Hospital of Lausanne
- Swiss National Science Foundation (SNF) [326030_150816, 32003B_159714] Funding Source: Swiss National Science Foundation (SNF)
Delta ADC measured with diffusion-weighted magnetic resonance imaging can predict kidney function decline and dialysis initiation in patients with native kidney disease or kidney allograft, independent of baseline kidney function and proteinuria.
Kidney cortical interstitial fibrosis is highly predictive of kidney prognosis and is currently assessed by evaluation of a biopsy. Diffusion-weighted magnetic resonance imaging is a promising non-invasive tool to evaluate kidney fibrosis. We recently adapted diffusion-weighted imaging sequence for discrimination between the kidney cortex and medulla and found that the cortico-medullary difference in apparent diffusion coefficient (Delta ADC) correlated with histological interstitial fibrosis. Here, we assessed whether Delta ADC as measured with diffusion-weighted magnetic resonance imaging is predictive of kidney function decline and dialysis initiation in chronic kidney disease (CKD) and patients with a kidney allograft in a prospective study encompassing 197 patients. We measured Delta ADC in 43 patients with CKD (estimated GFR (eGFR) 55ml/min/1.73m(2)) and 154 patients with a kidney allograft (eGFR 53ml/min/1.73m(2)). Patients underwent a kidney biopsy and diffusion-weighted magnetic resonance imaging within one week of biopsy; median follow-up of 2.2 years with measured laboratory parameters. The primary outcome was a rapid decline of kidney function (eGFR decline over 30% or dialysis initiation) during follow up. Significantly, patients with a negative Delta ADC had 5.4 times more risk of rapid decline of kidney function or dialysis (95% confidence interval: 2.29-12.58). After correction for kidney function at baseline and proteinuria, low ADC still predicted significant kidney function loss with a hazard ratio of 4.62 (95% confidence interval 1.56-13.67) independent of baseline age, sex, eGFR and proteinuria. Thus, low Delta ADC can be a predictor of kidney function decline and dialysis initiation in patients with native kidney disease or kidney allograft, independent of baseline kidney function and proteinuria.
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