Article
Parasitology
Pornpawee Sookpongthai, Korawich Utayopas, Thassanai Sitthiyotha, Theerakamol Pengsakul, Morakot Kaewthamasorn, Kittikhun Wangkanont, Pongchai Harnyuttanakorn, Surasak Chunsrivirot, Sittiporn Pattaradilokrat
Summary: This study investigated the global diversity of Pfs25 in P. falciparum populations, identifying 11 unique haplotypes, with H1 and H2 as the major haplotypes. The distribution patterns of these haplotypes varied across different geographical populations, with limited polymorphism likely due to negative selection.
PARASITES & VECTORS
(2021)
Article
Multidisciplinary Sciences
Rebecca L. Clements, Alexander A. Morano, Francesca M. Navarro, James P. McGee, Esrah W. Du, Vincent A. Streva, Scott E. Lindner, Jeffrey D. Dvorin
Summary: This study identifies a basal complex protein, PfBLEB, as a key player in gametocytogenesis. Parasites lacking PfBLEB are unable to form mature gametocytes, highlighting the importance of PfBLEB. The study also provides a potential molecular target for the eradication of malaria transmission.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Giulia Siciliano, Veronica Di Paolo, Dante Rotili, Rossella Migale, Francesca Pedini, Marialuisa Casella, Serena Camerini, Daniele Dalzoppo, Rob Henderson, Tonnie Huijs, Koen J. Dechering, Antonello Mai, Anna Maria Caccuri, Marco Lalle, Luigi Quintieri, Pietro Alano
Summary: This work investigates the activity of NBDHEX and its carboxylic acid metabolite on the human malaria parasite Plasmodium falciparum. NBDHEX shows strong activity against all blood stages of the parasite, with a higher potency against the gametocytes. Covalent modifications of gametocyte proteins are found to be associated with the antiparasitic effect of NBDHEX. Both NBDHEX and its metabolite have limited cytotoxicity in vitro, making them potential starting points for the development of new drugs to block malaria transmission.
Article
Immunology
Rebecca Webster, Hayley Mitchell, Jenny M. Peters, Juanita Heunis, Brighid O'Neill, Jeremy Gower, Sean Lynch, Helen Jennings, Fiona H. Amante, Stacey Llewellyn, Louise Marquart, Adam J. Potter, Geoffrey W. Birrell, Michael D. Edstein, G. Dennis Shanks, James S. McCarthy, Bridget E. Barber
Summary: A single low dose of tafenoquine can effectively reduce the transmission of Plasmodium falciparum parasites to mosquitoes, although there is a delay in its effect.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R. Trenholme, Julie Healer, Alan F. Cowman, Emily M. Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J. Blanch, Matthew W. A. Dixon, Leann Tilley, Michael F. Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, Anthony T. Papenfuss, Louis Schofield, Paul Griffin, Bridget E. Barber, Dean Andrew, Michelle J. Boyle, Fabian de Labastida Rivera, Christian Engwerda, James S. McCarthy
Summary: A genetically attenuated blood-stage malaria vaccine was developed and tested in healthy volunteers, showing immunogenicity but causing significant parasitemia at high doses.
Review
Chemistry, Medicinal
Sara Consalvi, Chiara Tammaro, Federico Appetecchia, Mariangela Biava, Giovanna Poce
Summary: Even though more research and a deeper understanding of parasite sexual stages biology are needed, the development of novel strategies to block transmission has significantly accelerated. Among the innovative patented inventions, the surface-delivery of antimalarial drugs to kill transmission-stages parasites in mosquitoes shows the highest promise for success in malaria control strategies, opening up new possibilities in malaria transmission-blocking drug discovery.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2022)
Article
Immunology
Basil T. Thommen, Armin Passecker, Tamara Buser, Eva Hitz, Till S. Voss, Nicolas M. B. Brancucci
Summary: This study found that certain drugs can increase the sexual commitment rates of malaria parasites in vitro. However, this effect is only observed at concentrations that inhibit parasite survival and does not often result in a net increase in gametocyte production. The study also suggests that the gametocytogenesis-promoting effect of drugs is related to general stress responses rather than specific compound activities.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Theresa Reiker, Monica Golumbeanu, Andrew Shattock, Lydia Burgert, Thomas A. Smith, Sarah Filippi, Ewan Cameron, Melissa A. Penny
Summary: Individual-based models are essential in the global fight against infectious diseases, but the complexity of the models can pose challenges for calibration. The authors propose using a Bayesian optimization framework to calibrate a complex malaria transmission simulator, resulting in improved fitting outcomes compared to previous calibrations.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Eizo Takashima, Bernard N. Kanoi, Hikaru Nagaoka, Masayuki Morita, Ifra Hassan, Nirianne M. Q. Palacpac, Thomas G. Egwang, Toshihiro Horii, Jesse Gitaka, Takafumi Tsuboi
Summary: Concerted efforts to fight malaria have led to significant reductions in global malaria cases and mortality. Sustaining these efforts is crucial to prevent a rebound and outbreaks of seasonal malaria. Identifying predictive attributes that define clinical malaria will be essential in developing second-generation tools to combat malaria.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Harvie P. Portugaliza, H. Magloire Natama, Pieter Guetens, Eduard Rovira-Vallbona, Athanase M. Some, Aida Millogo, D. Florence Ouedraogo, Innocent Valea, Hermann Sorgho, Halidou Tinto, Nguyen Van Hong, Antonio Sitoe, Rosauro Varo, Quique Bassat, Alfred Cortes, Anna Rosanas-Urgell
Summary: The study found that in most infections from African cohorts, increased expression of pfap2-g and other sexual ring biomarkers was observed after treatment. The estimated parasite age at the time of treatment was negatively correlated with the increase in pfap2-g transcript levels, suggesting that younger parasites are less susceptible to stimulation of sexual conversion.
Article
Immunology
Stephen Tottey, Yoko Shoji, R. Mark Jones, Konstantin Musiychuk, Jessica A. Chichester, Kazutoyo Miura, Luwen Zhou, Shwu-Maan Lee, Jordan Plieskatt, Yimin Wu, Carole A. Long, Stephen J. Streatfield, Vidadi Yusibov
Summary: Malaria kills a significant number of people, especially young children. A study demonstrates an improved virus-like particle antigen display molecule for a leading malaria transmission-blocking antigen. This re-engineered molecule shows higher antigen display and enhanced transmission-blocking activity in a mouse model.
Article
Immunology
Roos M. de Jong, Manon Alkema, Tate Oulton, Elin Dumont, Karina Teelen, Rie Nakajima, Rafael Ramiro de Assis, Kathleen W. Dantzler Press, Priscilla Ngotho, Kevin K. A. Tetteh, Phil Felgner, Matthias Marti, Katharine A. Collins, Chris Drakeley, Teun Bousema, Will J. R. Stone
Summary: This study investigates the antibody responses to sexual stage antigens in individuals infected with P. falciparum. The results show that even after exposure to relatively low gametocyte densities, a significant anti-sexual stage humoral response is induced in malaria-naive individuals. The study identifies novel antigens associated with gametocyte exposure, which can be used for surveillance of the malaria infectious reservoir and support vaccine development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Benyl M. Ondeto, Xiaoming Wang, Harrysone Atieli, Daibin Zhong, Guofa Zhou, Ming-Chieh Lee, Pauline Winnie Orondo, Kevin O. Ochwedo, Collince J. Omondi, Simon M. Muriu, David O. Odongo, Horace Ochanda, James Kazura, Andrew K. Githeko, Guiyun Yan
Summary: Despite initial reductions in asymptomatic malaria parasite prevalence among school children from 2005 to 2008 in all sites, a resurgence of parasite prevalence by over 40% has been observed in Kombewa and Marani since 2011. The study also found that Kombewa had a higher risk of infection compared to Iguhu and Marani.
PARASITES & VECTORS
(2022)
Article
Biotechnology & Applied Microbiology
Matthew B. Laurens
Summary: Malaria vaccines, including the RTS,S/AS01 vaccine, are showing moderate efficacy and new approaches are being developed for next-generation vaccines. Techniques such as RNA vaccine delivery and whole organism vaccination are being explored, with the goal of creating highly effective malaria vaccines that provide sustained protection.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Immunology
Mariette E. van der Watt, Janette Reader, Lyn-Marie Birkholtz
Summary: This article discusses the complex life cycle of Plasmodium parasites in humans and Anopheles vectors, emphasizing the unique role of gametocytes in the transmission process and the importance of transmission-blocking antimalarials.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Neha Chaturvedi, Sri Krishna, Praveen K. Bharti, Deepak Gaur, Virander S. Chauhan, Neeru Singh
INDIAN JOURNAL OF MEDICAL RESEARCH
(2017)
Article
Marine & Freshwater Biology
Xiao-li Li, Thomas Kiran Marella, Ling Tao, Rong Li, Archana Tiwari, Gu Li
PHYCOLOGICAL RESEARCH
(2017)
Article
Engineering, Environmental
Xiao-li Li, Thomas Kiran Marella, Ling Tao, Liang Peng, Chao-feng Song, Li-li Dai, Archana Tiwari, Gu Li
WATER SCIENCE AND TECHNOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Nisha Gaur, Aayush Kukreja, Mahavir Yadav, Archana Tiwari
Article
Biotechnology & Applied Microbiology
Nisha Gaur, Aayush Kukreja, Mahavir Yadav, Archana Tiwari
Article
Biology
Thomas Kiran Marella, Narasimha Reddy Parine, Archana Tiwari
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2018)
Article
Oncology
Neha Wadhwa, Blessy Baby Mathew, Sumit Tandon, Vinai George Biju, Archana Tiwari
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2018)
Article
Agricultural Engineering
Thomas Kiran Marella, Aviraj Datta, Mukund D. Patil, Sreenath Dixit, Archana Tiwari
BIORESOURCE TECHNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Himani Kaushik, Sachin Kumar Deshmukh, Amit Kumar Solanki, Bharti Bhatia, Archana Tiwari, Lalit C. Garg
Article
Immunology
Hina Singh, Syed Yusuf Mian, Alok K. Pandey, Sri Krishna, Gaurav Anand, K. Sony Reddy, Neha Chaturvedi, Vanndita Bahl, Nidhi Hans, Man Mohan Shukla, Quique Bassat, Alfredo Mayor, Kazutoyo Miura, Praveen K. Bharti, Carole Long, Neeru Singh, Virander Singh Chauhan, Deepak Gaur
Summary: This study evaluated 25 triple antibody combinations for parasite neutralization activity against clinical isolates and identified the MSP-Fu+CyRPA+RH5 antibody combination as having the maximal neutralization effect against variable P. falciparum parasites. This suggests that these antibody combinations could be promising candidate antigens for a potential blood-stage malaria vaccine.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Syed Yusuf Mian, Anjali Somanathan, Kritika Chaddha, Alok K. Pandey, Hina Singh, Sri Krishna, Neha Chaturvedi, Seemalata Uchoi, Man Mohan Shukla, Praveen K. Bharti, Neeru Singh, Virander Singh Chauhan, Deepak Gaur
Summary: This study investigated the protective antigen CyRPA of Plasmodium falciparum and its neutralizing activity against naturally acquired human antibodies. The results showed that CyRPA is a highly conserved antigen that is susceptible to immune attack, but the acquisition rate of anti-CyRPA antibodies is low in malaria-exposed individuals in India. Additionally, a CyRPA-based vaccine formulation induced potent antibodies in rabbits.
INFECTION AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
P. Arora, G. Singh, A. Tiwari
CELLULAR AND MOLECULAR BIOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Hemlata, Arif Tasleem Jan, Archana Tiwari
CURRENT DRUG METABOLISM
(2017)
Article
Biotechnology & Applied Microbiology
Sonal Jain, Sheetal Chouhan, Kirti J. Chavan, Pushpendra Singh, Archana Tiwari
MINERVA BIOTECNOLOGICA
(2016)
Review
Biotechnology & Applied Microbiology
Priya Pradhan, Nishant Soni, Lalitesh Chaudhary, Pushpendra Singh, Archana Tiwari
MINERVA BIOTECNOLOGICA
(2016)
