Pharmacological targeting of Tripartite Motif Containing 24 for the treatment of glioblastoma

Glioblastoma (GBM) is the most aggressive brain tumor of the central nervous system. Recent studies have reported the crucial functions of Tripartite Motif Containing 24 (TRIM24) in promoting cancer progression of GBM. However, it remains unclear if TRIM24 is an attractive druggable target for therapeutic intervention in GBM. We therefore performed a series of experiments, aiming to verify whether specific TRIM24 inhibition suppresses GBM malignant functions using dTRIM24 and IACS-9571, two novel selective TRIM24 antagonists. Our data showed that TRIM24 inhibitors serve as effective agents for inhibiting cell propagation and invasion of several patient-derived GBM stem cells (GSCs), and these effects are mediated partially through suppression of the TRIM24-SOX2 axis. This study provides novel insight into the TRIM24-based druggable dependencies, important for developing effective therapeutic strategies for brain tumors.

Automated summary

This study demonstrates the importance of TRIM24 in suppressing malignant functions of GBM, particularly through the inhibition of the TRIM24-SOX2 axis. The findings suggest that TRIM24 inhibitors could be effective agents for targeting GBM and developing therapeutic strategies for brain tumors.