Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

(2021) Andrew K. Dilger et al.   JOURNAL OF MEDICINAL CHEMISTRY

First‐in‐human study of milvexian, an oral, direct, small molecule factor XIa inhibitor

(2021) Vidya Perera et al.   CTS-Clinical and Translational Science

Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty

(2020) Jeffrey I. Weitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Factor XIa Inhibitors as New Anticoagulants

(2018) Mimi L. Quan et al.   JOURNAL OF MEDICINAL CHEMISTRY

2017 Scientific Sessions Sol Sherry Distinguished Lecture in Thrombosis

(2017) Jeffrey I. Weitz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Factor XI as a Therapeutic TargetHighlights

(2016) David Gailani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The safety of chronic antithrombotic therapy in patients with factor XI deficiency

(2016) John Chapin et al.   BRITISH JOURNAL OF HAEMATOLOGY

In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa

(2015) Pancras C. Wong et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

(2015) Harry R. Büller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit

(2015) Zhu Chen et al.   Molecular Therapy-Nucleic Acids

Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: Murine Ortholog of the Fletcher Trait

(2013) Patricia Smith et al.   THROMBOSIS AND HAEMOSTASIS

Activation of factor XI by products of prothrombin activation

(2011) A. Matafonov et al.   BLOOD

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

(2011) A. S. Revenko et al.   BLOOD

A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits

(2011) Pancras C. Wong et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Inhibition of Factor XIa as a New Approach to Anticoagulation

(2010) William A. Schumacher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structure and function of factor XI

(2010) J. Emsley et al.   BLOOD

BMS-593214, an active site-directed factor VIIa inhibitor: Enzyme kinetics, antithrombotic and antihaemostatic studies

(2010) Joseph Luettgen et al.   THROMBOSIS AND HAEMOSTASIS

Factor XI deficiency in humans

(2009) U. SELIGSOHN   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits

(2009) Donglu Zhang et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Apixaban, an oral, direct and highly selective factor Xa inhibitor:in vitro, antithrombotic and antihemostatic studies

(2008) P. C. WONG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clopidogrel versus prasugrel in rabbits

(2008) Carol Watson et al.   THROMBOSIS AND HAEMOSTASIS