Synergic efficacy of bioenergy expression for compound herbal medicine of Parkinson's disease: The methods of replacement series and concentration addition

Background: Herbal medication has been used for thousands of years. Although synergic efficiency of compound herbal medicine to humans have been explored for years, detailed mechanisms behind this cocktail medication still required open for discussion. Method: With electrochemical inspections, this feasibility study tended to decipher combined interactions of synergy and antagonism of Levodopa (L-DOPA) and tea extracts of Camellia sinensis (L.) Kuntze (green tea) and Camelliaboreali-yunnanica (black tea) extracted from different temperatures via total phenolics concentrations, DPPH free radical scavenging ability, bioelectricity-generating capability of microbial fuel cells for bioenergy expression. Significance of findings: According to replacement series and concentration addition (CA) methods, the most significant synergistic effect was quantitatively disclosed at the ratio of L-DOPA: tea extract at 80:20. This work provided the novel means revealing synergic efficacy of herbal medicine via the perspective of bioenergy extraction for medication. The rankings of power-stimulating efficiency in DC-MFC modules were HG2 > CG2 > HR2 > CR2. The replacement-series method indicated that both L-DOPA and tea extracts did not own tendency to out-compete each other. The CA method revealed that both L-DOPA and tea extracts were dis-similar and synergistic in action of bioenergy extraction. The most promising ratio of interactive synergy is L-DOPA: tea extract at 80:20. (c) 2022 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Automated summary

This study used electrochemical inspections to investigate the synergistic and antagonistic effects between levodopa and green tea and black tea extracts. The results revealed that the most significant synergistic effect was observed at the ratio of L-DOPA: tea extract of 80:20. This study provides a novel approach to understand the synergistic efficacy of herbal medicine through the perspective of bioenergy extraction.