Article
Reproductive Biology
Atieh Hajarizadeh, Akram Eidi, Ehsan Arefian, Eva Tvrda, Abdollah Mohammadi-Sangcheshmeh
Summary: Aflatoxin B1 (AFB1) negatively affects the development of sheep oocytes and embryonic development, leading to decreased meiotic and cytoplasmic maturation, increased intracellular reactive oxygen species (ROS) production, decreased mitochondrial membrane potential, and altered gene expression related to apoptosis and DNA methylation.
Article
Biochemistry & Molecular Biology
Ahmed Atef Mesalam, Marwa El-Sheikh, Myeong-Don Joo, Atif Ali Khan Khalil, Ayman Mesalam, Mi-Jeong Ahn, Il-Keun Kong
Summary: Exposing bovine oocytes to juglone at concentrations of 12.5-50.0 μM significantly impairs their development by inducing ROS accumulation, apoptosis, and mitochondrial dysfunction. This study provides insights into the adverse effects of juglone treatment on oocyte maturation and embryo development, highlighting the importance of understanding the impact of traditional medicinal components on reproductive processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ting Liu, Li Sun, Yubin Zhang, Yonglin Wang, Jiang Zheng
Summary: This article reviews the impact of imbalance between ROS and GSH on cells, indicating that imbalance may lead to cell death. In addition, different factors leading to the disruption of cellular ROS and GSH balance are introduced.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Oncology
Hailong Shi, Yuanyuan Cheng, Qimei Shi, Wenzhi Liu, Xue Yang, Shuang Wang, Lin Wei, Xiangming Chen, Hao Fang
Summary: Myoferlin is a newly identified oncogene that is associated with tumor metastasis, intracellular ROS production, and energy metabolism. Its function in regulating gastric cancer cell migration and ROS accumulation has not been determined.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Beatriz Castejon-Vega, Mario D. D. Cordero, Alberto Sanz
Summary: In the past, mtROS were seen as byproducts of cellular metabolism and drivers of ageing and age-related diseases. Now, we know that mtROS serve as important cellular messengers, playing a role in maintaining cellular homeostasis and influencing cellular differentiation, proliferation, and survival. However, dysregulated mtROS signaling can contribute to degenerative diseases. This review focuses on the signaling pathways involving mtROS and their role in ageing.
Article
Reproductive Biology
Jose M. Ortiz-Rodriguez, Francisco E. Martin-Cano, Gemma L. Gaitskell-Phillips, Antonio Silva, Cristina Ortega-Ferrusola, Maria C. Gil, Fernando J. Pena
Summary: Energy metabolism in sperm involves complex processes such as ATP production in mitochondria and contribution of glycolytic enzymes in flagella. Low glucose concentrations may support better sperm motility and velocity by providing efficient substrates for tricarboxylic acid cycle, leading to reduced levels of damaging compounds like 2-oxoaldehydes in high glucose extenders.
BIOLOGY OF REPRODUCTION
(2021)
Article
Environmental Sciences
Quan-Kuo He, Chang-Long Xu, Yan-Ping Li, Zhi-Ran Xu, Yu-Shen Luo, Si-Cheng Zhao, Hai-Long Wang, Zhong-Quan Qi, Yu Liu
Summary: The study reported that exposure to Captan affected mouse ovarian homeostasis and disrupted female hormone receptor expression, leading to impaired follicular development. Captan exposure also disrupted oocyte development, changing the expression of multiple genes related to autophagy and apoptosis. Additionally, Captan induced oxidative stress, mitochondrial dysfunction, DNA damage, autophagy, and early apoptosis in the ovaries.
Article
Environmental Sciences
Cai-feng Fei, Shi-meng Guo, Ying Yin, Ximiao He, Li-quan Zhou
Summary: N,N-dimethylformamide (DMF) is a widely-used solvent with diverse applications, but its biological toxicity on mammalian reproduction has not been thoroughly explored. Our study found that DMF exposure inhibited oocyte maturation and fertilization ability. It caused mitochondrial dysfunction, abnormal aggregation of mitochondria, and decreased mitochondrial membrane potential in mouse oocytes. Additionally, DMF exposure led to abnormal distribution of Golgi apparatus and endoplasmic reticulum, oxidative stress, disordered spindle, chromosome abnormality, and reduced histone modification levels in oocytes.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Jingyue Chen, Zhaokang Cui, Yawei Qiu, Xingxing Zhang, Fang Chen, Huili Wang, Bo Xiong, Yilong Miao, Qian Gao
Summary: Excessive copper exposure negatively impacts the maturation and organelle functions of porcine oocytes, disrupting spindle structure, altering actin dynamics and cortical granule distribution. It also affects mitochondrial function, leading to increased oxidative stress, DNA damage, and apoptosis in the oocytes, ultimately reducing oocyte quality.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Vujic, Amy N. M. Koo, Hiran A. Prag, Thomas Krieg
Summary: Mitochondria play a crucial role in cellular processes and heart function, with communication between mitochondria and the nucleus maintaining cardiomyocyte homeostasis. Excessive generation of ROS can lead to irreversible cell damage, contributing to various pathologies. Additionally, myocardial impairments are associated with specific metabolic changes and dysregulated inflammatory responses.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Bin Lv, Jingru Ma, Yumeng Wang, Xinyu Qu, Junjun Qiu, Keqin Hua
Summary: In this study, TPP-modified DMON nanoplatforms were developed to deliver DDP to mitochondria, overcoming DDP resistance. TPP facilitated the migration of nanoplatforms to mitochondria, and the S-S bond of DMON depleted mitochondrial glutathione, leading to mitochondrial redox dyshomeostasis and increased sensitivity to DDP.
FRONTIERS IN CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Xiaoting Zhou, Biao An, Yi Lin, Yanghong Ni, Xia Zhao, Xiao Liang
Summary: Drug resistance is a major obstacle in curing cancer patients. Reactive oxygen species (ROS) play a crucial role in modulating drug resistance in cancer cells, with higher levels seen in drug-resistant cells compared to non-resistant cells. Understanding the functions of ROS in drug resistance can help develop therapies to sensitize cancer cells. This review summarizes literature on ROS production, regulation, and their complex roles in cancer chemoresistance, including transcription factor-mediated resistance and impact on the tumor microenvironment. The potential of ROS-targeted therapies in overcoming therapeutic resistance is also discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Jinghan Yuan, Manda Wang, Yanrong Pan, Min Liang, Yu Fu, Yimei Duan, Mi Tang, Ismail Laher, Shunchang Li
Summary: The study found that MOTS-c can improve myocardial mechanical efficiency, enhance cardiac systolic function, and have a certain improvement in diastolic function. This suggests that using exercise supplements may help modulate the cardiovascular benefits of athletic training.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jorge Reyes-Garcia, Abril Carbajal-Garcia, Annarita Di Mise, Yun-Min Zheng, Xiangdong Wang, Yong-Xiao Wang
Summary: Mitochondria play important roles in the development of pulmonary hypertension, including ROS production, regulation of Ca2+ signaling, fatty acid oxidation, and ketone synthesis. Dysfunction of mitochondrial ROS and Ca2+ signaling can lead to inflammatory responses and oxidative stress mediated by ketones, contributing to the progression of pulmonary hypertension and associated diseases.
Article
Biochemistry & Molecular Biology
Wu-Sheng Sun, Hoon Jang, Mi-Ryung Park, Keon Bong Oh, Haesun Lee, Seongsoo Hwang, Li-Jie Xu, In-Sul Hwang, Jeong-Woong Lee
Summary: The study suggests that N-acetyl-L-cysteine (NAC) supplementation during in vitro culture has beneficial effects on bovine oocytes and embryos by reducing intracellular reactive oxygen species (ROS) and promoting intracellular glutathione levels. NAC also influences early embryonic development with both dose-dependent and stage-specific effects, leading to improved developmental rates and reduced apoptosis.
Article
Agriculture, Dairy & Animal Science
Ruilan Li, Xiaomei Fan, Tong Zhang, Huizi Song, Xiaona Bian, Rile Nai, Jinquan Li, Jiaxin Zhang
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Tong Zhang, Xiaomei Fan, Ruilan Li, Chunqiang Zhang, Jiaxin Zhang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Tong Zhang, Xiaofang Zhao, Rihan Hai, Ruilan Li, Wenguang Zhang, Jiaxin Zhang
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2019)
Article
Agriculture, Dairy & Animal Science
Tong Zhang, Jiaxin Zhang, Ruilan Li
Summary: This study investigated the expression pattern and functional characteristics of p66Shc during preimplantation embryo development in sheep. The results showed that p66Shc was expressed in all stages of sheep early embryos and its expression was regulated during embryonic genome activation. RNAi-mediated knockdown of p66Shc resulted in decreased levels of ROS and DNA damage, and increased levels of antioxidant enzymes. This suggests that p66Shc is involved in the regulation of oxidative stress and DNA damage during sheep early embryonic development.