期刊
IMMUNOLOGY LETTERS
卷 178, 期 -, 页码 45-49出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2016.04.009
关键词
Immunoglobulin A; Microbiota; Genetic background
类别
资金
- European Research Council (Homeogut)
- Italian Association for Cancer Research (AIRC)
- Italian Ministry of Health
- FIRC fellowships
Although immunoglobulins (Ig) of the A isotype were discovered more than 50 years ago, their homeostatic function, production and specificity has only lately started to be unravelled. We have recently described that the level of IgAs is genetically determined and contributes to microbiota diversification via establishing a positive feedback loop of IgA production. Here we show that the amount of both fecal and serum IgAs is intermediate in a Fl BALB/c x C57BL/6 mixed background. Naive mice that have never been exposed to certain bacterial strains but that carry innate IgAs that react towards those bacteria undergo de novo differentiation of antigen-specific responses, indicating that there is not just a recall of a pre-existing innate IgA response. We also demonstrate that, differently from pathogenic bacteria, a commensal does not induce systemic IgG response but only a mucosal IgA response. Thus IgAs come into different flavours and can potentiate their own production, but also drive the development of new specificities. (C) 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据