Review
Biochemistry & Molecular Biology
Chao-Yi Wu, Huang-Yu Yang, Jing-Long Huang, Jenn-Haung Lai
Summary: Monocytes and macrophages play a crucial role in the pathogenesis of juvenile idiopathic arthritis (JIA), with their activation being linked to inflammation regulation and tissue repair mechanisms in the disease process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yijun Lin, Meiqin Huang, Shuo Wang, Xue You, Lingling Zhang, Yan Chen
Summary: PAQR11 plays a critical role in monocyte-to-macrophage differentiation by promoting cell survival, and its function is associated with autoimmune diseases in vivo.
Article
Cell Biology
Taylor Schmit, Kai Guo, Jitendra Kumar Tripathi, Zhihan Wang, Brett McGregor, Mitch Klomp, Ganesh Ambigapathy, Ramkumar Mathur, Junguk Hur, Michael Pichichero, Jay Kolls, M. Nadeem Khan
Summary: This study identifies IFN-gamma-regulated CCR2(+) monocytes as the main driver of lung damage during IAV infection. IFN-gamma regulates the recruitment and inflammatory phenotype of CCR2(+) monocytes. CD8+ T cells are the main source of IFN-gamma in the infected lungs.
Review
Microbiology
Haoning Li, Aoxue Wang, Yuying Zhang, Fanhua Wei
Summary: Influenza viruses are a major cause of human respiratory infections and pose a significant threat to global public health systems. Lung macrophages play an important role in controlling the severity of influenza by limiting viral replication, but this replication is strain- and macrophage type-dependent.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Wen Yu, Shu Wang, Yangyang Wang, Hui Chen, Hao Nie, Lian Liu, Xiaoting Zou, Quan Gong, Bing Zheng
Summary: Macrophages play important roles in liver fibrosis by triggering inflammation and activating hepatic stellate cells. MicroRNAs have unique regulatory roles in macrophage activation, polarization, tissue infiltration, and inflammation regression. Understanding the heterogeneity of hepatic macrophages and the role of miRNAs in macrophage polarization provides valuable insights for further research and the development of new therapies for liver fibrosis targeting miRNAs and macrophage subsets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cody J. Gurski, Bonnie N. Dittel
Summary: Macrophages are important cells in the body that maintain homeostasis and defend against microorganisms. Myeloperoxidase (MPO) can be used as a marker to differentiate between different subsets of monocytes/macrophages with pro-inflammatory and microbicidal activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mita Varghese, Jeremy Clemente, Arianna Lerner, Simin Abrishami, Mohammed Islam, Perla Subbaiah, Kanakadurga Singer
Summary: This study reveals sexual dimorphism in adipose tissue macrophages (ATMs) in male and female mice under a high fat diet, using RNA-seq and chemotaxis assays. The findings suggest that sex hormones may play a role in regulating inflammatory responses associated with obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Amanda Thomson, Catharien M. U. Hilkens
Summary: Effective treatment of osteoarthritis remains challenging due to the heterogeneity of patients and the involvement of inflammation and macrophages in disease progression. Understanding the role of macrophages may lead to improved treatments for OA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaowei Gu, Shu-Yun Li, Tony DeFalco
Summary: Gonad development is a tightly regulated process that involves cell differentiation and morphogenesis to produce sex-specific organ structures necessary for fertility. Immune and vascular cells play crucial roles in sexual differentiation and organogenesis of the gonad, opening up a new avenue for research in this field.
Article
Immunology
Fei Hou, Huan Wang, Kun Zheng, Wenting Yang, Kun Xiao, Zihan Rong, Junjie Xiao, Jing Li, Baihe Cheng, Li Tang, Lixin Xie
Summary: In acute lung injury, two subsets of lung macrophages, tissue-resident alveolar macrophages (AMs) and monocyte-derived alveolar macrophages (MDMs), have different functions and characteristics during the recovery phase. AMs have a higher ability to proliferate and phagocytose, while MDMs activate lymphocytes and express pro-repairing genes. MDMs play a paradoxical role in promoting tissue repair despite being pro-inflammatory early in infection.
Review
Cell Biology
Joana Saavedra, Mariana Nascimento, Marcia A. Liz, Isabel Cardoso
Summary: The article introduces the features and pathological process of Alzheimer's disease (AD), pointing out that a neurocentric approach is not sufficient to study AD, and the role of other brain cells should also be considered. Understanding the interactions between different brain cells is crucial for developing therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physiology
Peter K. Moore, Kelsey C. Anderson, Shannon A. McManus, Ting -Hui Tu, Emily M. King, Kara J. Mould, Elizabeth F. Redente, Peter M. Henson, William J. Janssen, Alexandra L. McCubbrey
Summary: This study characterized the subtypes and transcriptomic profiles of interstitial macrophages (IMs) in the lung during homeostasis and acute lung inflammation induced by lipopolysaccharide (LPS). The results show that IMs can be divided into distinct subsets based on the expression of folate receptor I3 (FRI3), and during inflammation, there are recruited monocyte-derived IMs with unique gene expression profiles. These findings suggest that IMs have different functions during inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Clinical Neurology
Keun Woo Park, Hyunwoo Ju, Il-Doo Kim, John W. Cave, Yang Guo, Wei Wang, Zhuhao Wu, Sunghee Cho
Summary: The study found that monocyte-derived macrophages (MDMs) play a role in the progressive stroke-induced injury and repair processes. Manipulating monocyte entry at different stroke stages may be an effective immune-based strategy to limit injury propagation in chronic stroke.
Review
Immunology
Yiwen Liu, Yan Gong, Gaosi Xu
Summary: Although the multiple hits theory is widely accepted in IgA nephropathy, increasing evidence suggests that the mononuclear/macrophage system plays important roles in disease progression, but the exact mechanism is unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Ansam Sinjab, Zahraa Rahal, Humam Kadara
Summary: Advances in single-cell sequencing have greatly improved our understanding of lung cancer, particularly lung adenocarcinoma. By studying lung adenocarcinomas at a cellular level, we have discovered new insights into tumor heterogeneity, cell plasticity, and the complex biology of premalignant progression. This knowledge is guiding the development of novel approaches for clinical management of this deadly disease.
Article
Multidisciplinary Sciences
Yi-pin Lv, Ping Cheng, Jin-yu Zhang, Fang-yuan Mao, Yong-sheng Teng, Yu-gang Liu, Hui Kong, Xiao-long Wu, Chuan-jie Hao, Bin Han, Qiang Ma, Shi-ming Yang, Weisan Chen, Liu-sheng Peng, Ting-ting Wang, Quan-ming Zou, Yuan Zhuang
Article
Medicine, General & Internal
Pece Kocovski, Xiangrui Jiang, Claretta S. D'Souza, Zhenjiang Li, Phuc T. Dang, Xiaowei Wang, Weisan Chen, Karlheinz Peter, Matthew W. Hale, Jacqueline M. Orian
JOURNAL OF CLINICAL MEDICINE
(2019)
Review
Biochemistry & Molecular Biology
Manman Dai, Chenggang Xu, Weisan Chen, Ming Liao
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Tze Cin Owyong, Pramod Subedi, Jieru Deng, Elizabeth Hinde, Jason J. Paxman, Jonathan M. White, Weisan Chen, Begona Heras, Wallace W. H. Wong, Yuning Hong
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Virology
Mengdie Ye, Yixian Liao, Li Wu, Wenbao Qi, Namrta Choudhry, Yahong Liu, Weisan Chen, Gaopeng Song, Jianxin Chen
Article
Cell Biology
Yongsheng Teng, Baocheng Cang, Fangyuan Mao, Weisan Chen, Ping Cheng, Liusheng Peng, Ping Luo, Dongshui Lu, Nan You, Quanming Zou, Yuan Zhuang
CELL DEATH & DISEASE
(2020)
Article
Medicine, Research & Experimental
Yu-gang Liu, Yong-sheng Teng, Zhi-guo Shan, Ping Cheng, Chuan-jie Hao, Yi-pin Lv, Fang-yuan Mao, Shi-ming Yang, Weisan Chen, Yong-liang Zhao, Nan You, Quan-ming Zou, Yuan Zhuang
Article
Oncology
Pouya Faridi, Katherine Woods, Simone Ostrouska, Cyril Deceneux, Ritchlynn Aranha, Divya Duscharla, Stephen Q. Wong, Weisan Chen, Sri H. Ramarathinam, Terry C. C. Lim Kam Sian, Nathan P. Croft, Chen Li, Rochelle Ayala, Jonathan S. Cebon, Anthony W. Purcell, Ralf B. Schittenhelm, Andreas Behren
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jieru Deng, Chunni Lu, Chuanxin Liu, Sara Oveissi, W. Douglas Fairlie, Erinna F. Lee, Pamuk Bilsel, Hamsa Puthalakath, Weisan Chen
Summary: The study demonstrates that IAV infection induces endogenous presentation of a viral epitope by MHC-II to CD4(+) T cells, dependent on de novo protein synthesis and the ER-Golgi network. Some antigenic peptides are of cytosolic origin in this process. Additionally, autophagy inhibitors and deletion of autophagy-related genes block most of the MHC-II-restricted endogenous IAV antigen presentation.
Article
Cell Biology
Chunni Lu, Weisan Chen
Summary: This study tracked different types of Treg cells in mice infected with influenza virus, finding that Foxp3(+)Helios(+) Tregs were mainly enriched in the lungs and lymph nodes, and these cells accumulated more rapidly during secondary infection with stronger suppressive function.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Virology
Miaojuan Huang, Rong Xu, Cristina Triffon, Nicole Mifsud, Weisan Chen
Summary: This study reveals a broad CD8(+) T cell response in a healthy individual to IAV infection, contrary to the typical immunodominance hierarchy. Through systematic antigen screening and epitope prediction, novel minimal epitope sequences for nine IAV proteins were identified, restricted to specific HLA alleles. These novel epitopes are highly conserved among different IAV strains and geographic locations.
Article
Multidisciplinary Sciences
E. A. Monson, K. M. Crosse, M. Duan, W. Chen, R. D. O'Shea, L. M. Wakim, J. M. Carr, D. R. Whelan, K. J. Helbig
Summary: Lipid droplets (LDs) are critical in enhancing modulation of IFN, controlling viral replication, and facilitating early antiviral immune response, marking a paradigm shift in understanding the molecular mechanisms of effective antiviral responses.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Jennifer Habel, Andrea Nguyen, Louise Rowntree, Christopher Szeto, Nicole Mifsud, E. Bridie Clemens, Liyen Loh, Weisan Chen, Steve Rockman, Jane W. Nelson, Jane Davies, Adrian Miller, Steven Y. C. T. Tong, Jamie Rossjohn, Stephanie M. Gras, Anthony Purcell, Luca M. Hensen, Katherine Kedzierska, Patricia M. Illing
Summary: HLA-A*11:01 is highly prevalent in East Asian and Oceanian populations and is associated with high risk of severe influenza disease. Using immunopeptidomics, researchers identified novel CD8(+) T cell targets for influenza A and influenza B viruses in HLA-A*11:01-expressing individuals. These findings have implications for the design of broadly cross-reactive influenza vaccines.
Article
Biochemistry & Molecular Biology
Xia Yang, Hailiang Sun, Zhening Zhang, Weixin Ou, Fengxiang Xu, Ling Luo, Yahong Liu, Weisan Chen, Jianxin Chen
Summary: Influenza A virus (IAV) infections pose a serious threat to public health and there is an urgent need for novel anti-IAV medications. This study reveals that ginsenoside rk1 (G-rk1) and G-rg5, derived from panax ginseng, exhibit significant antiviral effects against different IAV subtypes both in vitro and in vivo. G-rk1 specifically blocks IAV binding to sialic acid and interacts with HA1, making it a potential approach for preventing and treating IAV infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xia Yang, Feixiang Long, Weixin Jia, Mingxin Zhang, Guanming Su, Ming Liao, Zhenling Zeng, Weisan Chen, Jianxin Chen
Summary: We demonstrated that artemisinin and its derivative artesunate (AS) have broad antiviral activity against H5N1, H1N1, H3N2, and oseltamivir-resistant influenza A virus in vitro. AS treatment significantly protected mice from lethal challenges with H1N1 and H5N1 IAV, and the combination of AS and peramivir showed improved survival outcomes compared to monotherapy. Mechanistically, AS inhibited PDE4, induced cAMP accumulation, reduced ERK phosphorylation, and blocked IAV vRNP export, thus suppressing IAV replication.
ANTIVIRAL RESEARCH
(2023)