Article
Rheumatology
Risa Wakiya, Kiyo Ueeda, Hiromi Shimada, Shusaku Nakashima, Tomohiro Kameda, Nobuyuki Miyatake, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi
Summary: This study investigated the effects of supplemental HCQ treatment on serum cytokine levels associated with atherosclerosis in patients with stable SLE. The results showed that HCQ treatment increased serum adiponectin levels and decreased resistin levels. The improvement in adipokine levels may contribute to better prognosis by controlling disease activity and reducing the risk of atherosclerosis in SLE patients.
CLINICAL RHEUMATOLOGY
(2022)
Review
Nutrition & Dietetics
Masanori Kono, Yasuo Nagafuchi, Hirofumi Shoda, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease primarily affecting women, possibly due to environmental factors and genetic predisposition. Habits of high-fat diet and obesity could be related to the pathogenesis of SLE, with vitamin D and adipokines like leptin potentially playing a role in connecting obesity and SLE.
Review
Cell Biology
Alin Garcia-Miranda, Alejandra Garcia-Hernandez, Eduardo Castaneda-Saucedo, Napoleon Navarro-Tito, Paola Maycotte
Summary: Excess body weight and obesity have been identified as significant risk factors for cancer development, with adipokines playing a crucial role in promoting an inflammatory microenvironment conducive to carcinogenesis and tumor progression. Autophagy, a process implicated in both tumor suppression and cancer progression, has been suggested as a therapeutic target in cancer treatment, with its effectiveness potentially influenced by tumor type and microenvironmental conditions influenced by circulating adipokines.
Article
Rheumatology
Antonietta Gigante, Francesco Iannazzo, Luca Navarini, Maria Chiara Sgariglia, Domenico Paolo Emanuele Margiotta, Valentina Vaiarello, Federica Foti, Antonella Afeltra, Rosario Cianci, Edoardo Rosato
Summary: The study found a higher prevalence of MetS in patients with systemic lupus erythematosus compared to systemic sclerosis patients. In SLE patients, MetS was associated with adiponectin levels and inflammation/activity disease scores, while in SSc patients, it was associated with disease severity.
CLINICAL RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Andrea Marcinno, Erica Gallo, Fausto Roveta, Silvia Boschi, Alberto Grassini, Innocenzo Rainero, Elisa Rubino
Summary: This study investigated the expression of adiponectin, leptin, and resistin in Alzheimer's disease (AD) and Frontotemporal Dementia (FTD). The results showed that lower resistin concentrations were associated with an increased risk of dementia, particularly in AD. The study suggests that the resistin-linked metabolic profile should be further investigated in AD.
Article
Medicine, General & Internal
Sylwia Sluczanowska-Glabowska, Marzena Staniszewska, Mariola Marchlewicz, Ewa Duchnik, Karolina Luczkowska, Krzysztof Safranow, Boguslaw Machalinski, Andrzej Pawlik
Summary: Psoriasis is a common chronic skin disease characterized by hyperproliferation of keratinocytes, parakeratosis, and T-cell infiltration. Adipose tissue produces adipokines, including leptin, resistin, and adiponectin, which may play a role in the pathogenesis of psoriasis. This study examined the plasma levels of adiponectin, leptin, and resistin in psoriasis patients and their correlation with disease activity parameters and clinical parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Physiology
Lubica Cibickova, Michal Grega, Roman Dohnal, Jan Schovanek
Summary: Bariatric procedures, particularly laparoscopic sleeve gastrectomy (LSG), are highly effective in treating obesity. LSG leads to weight loss and metabolic improvement, as well as changes in adipokine levels. Adipokines, including leptin, resistin, visfatin, chemerin, adiponectin, and omentin, play a crucial role in regulating insulin resistance and chronic inflammation, and are significantly altered after LSG.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Environmental Sciences
Xin Wang, Carrie A. Karvonen-Gutierrez, Bhramar Mukherjee, William H. Herman, Sung Kyun Park
Summary: The study found that urinary molybdenum was positively associated with adipokine levels, while cadmium, cesium, and lead were negatively associated with adipokine levels.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Piotr Ostrowski, Bartlomiej Pala, Ewa Gromowska, Klaudia Gurazda, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Psoriasis is a chronic skin condition mediated by the immune system, characterized by inflammation and excessive skin cell growth. Dendritic cells, T lymphocytes, and keratinocytes play key roles in the development of psoriasis, while the IL-23/IL-17 pathway contributes to disease progression. Adipokines secreted by adipose tissue, such as adiponectin, leptin, visfatin, and resistin, have immunomodulatory effects and may influence the progression or suppression of psoriasis. Understanding the relationship between psoriasis and adipokines could lead to new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Shaimaa M. Kamel, Mervat E. (Mervat I. ) Abdel Azeem (Abd Elazeem), Rabab A. Mohamed, Mahmoud M. Kamel, Enas A. Abdel Aleem (Abdelaleem)
Summary: This study aimed to evaluate the associations of serum adiponectin and leptin with clinical manifestations and disease activity in SLE patients. The results showed that SLE patients had significantly higher serum leptin and adiponectin levels, which were positively correlated with SLEDAI scores. Higher serum leptin was significantly associated with lupus nephritis and several clinical and laboratory parameters, while higher adiponectin was significantly associated with lupus nephritis.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Review
Oncology
Georgios-Ioannis Verras, Levan Tchabashvili, David-Dimitris Chlorogiannis, Francesk Mulita, Maria-Ioanna Argentou
Summary: Breast cancer is a common and deadly disease, with obesity and hormonal changes being known risk factors. Adipokines, which are molecules related to fatty tissue, play a key role in these hormonal changes and have been linked to breast cancer development. This review aims to summarize the evidence and highlight the potential of adipokines as biomarkers, predictive indicators, and therapeutic targets for breast cancer.
Article
Health Care Sciences & Services
Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O'haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
Summary: The study found significantly altered concentrations of four adipokines, adiponectin, leptin, visfatin and chemerin, in the T2DM patient group compared to the controls, with more pronounced alterations in the obese and highly obese patients. This suggests that these four adipokines play a significant role in the onset, progression, and associated complications of T2DM. More research on a larger sample size is needed to further explore the relationship between adipokines and T2DM.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Kathrine Stenberg, Guy W. Novotny, Thomas A. Lutz, Thomas Mandrup-Poulsen, Charlotte Reinhard Bjornvad
Summary: Indoor-confined cats are prone to obesity due to sedentary lifestyle and excessive energy intake. This study investigated the changes in gene expression related to obesity in cats and found that adiponectin expression was negatively associated with obesity in adipose tissue. In muscle, the expression of peroxisome proliferative activated receptor-gamma 2 and plasminogen activator inhibitor-1 was increased in obese cats compared to normal-weight cats. No significant changes in the expression of inflammatory cytokines were observed. This suggests that feline obesity and insulin resistance may not be solely caused by tissue-derived inflammation, but by multiple factors that require further investigation.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Yisi Shan, Yeting Chen, Haiping Gu, Yadong Wang, Yaming Sun
Summary: Epilepsy is a neurological disorder characterized by impaired glucose metabolism and changes in neuronal excitability. Leptin and adiponectin, as important regulators of glucose metabolism, have been found to be strongly associated with epilepsy. Their role in epilepsy involves various aspects such as inflammation, oxidative damage, and neuronal apoptosis. This paper aims to summarize the signaling pathways and regulation of glucose metabolism related to leptin and adiponectin in epilepsy. It also discusses the dual effects of leptin and the relationship between antiepileptic drugs and the levels of these two adipokines. Understanding their specific involvement in the pathogenesis of epilepsy has practical significance for the personalized treatment of epilepsy according to individual metabolic characteristics.
NEUROCHEMICAL RESEARCH
(2023)
Article
Immunology
Liberato Giardullo, Addolorata Corrado, Nicola Maruotti, Daniela Cici, Natalia Mansueto, Francesco Paolo Cantatore
Summary: Adipokines have diverse effects on the pathogenesis and clinical manifestations of rheumatological diseases. Different adipokines can either promote or inhibit the development and clinical course of these diseases. Further research is needed to fully understand the role of adipokines in rheumatological diseases.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Rheumatology
Yan-Mei Mao, Tao Liao, Qian-Ling Ye, Guo-Cui Wu, Qin Zhang, Sha-Sha Tao, Chan-Na Zhao, Qian Wu, Yi-Lin Dan, Hai-Feng Pan, Dong-Qing Ye
Summary: This study evaluated the circulating level of sclerostin in rheumatoid arthritis (RA) patients and summarized its role. The meta-analysis showed that RA patients had higher circulating sclerostin levels compared to normal controls. Subgroup analyses indicated that age, region, and assay method were associated with sclerostin level in RA patients.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Environmental Sciences
Bo Liu, Xin-Yu Fang, Yu-Lu Yan, Jun Wu, Xiao-Jie Lv, Jie Zhang, Liang-Wei Qi, Ting-Ting Qian, Yu-Yu Cai, Yin-Guang Fan, Dong-Qing Ye
Summary: There is an association between ambient temperature and outpatient visits for warts, where both low and high temperatures increase the risk while a large temperature drop is protective. Males and younger individuals are more sensitive to temperature, while the elderly are more susceptible to temperature changes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
J. Ni, L-J Qiu, K-J Yin, G-M Chen, H-F Pan
Summary: This study found moderate genetic correlations between T2D and COVID-19 severity, but MR analysis did not support a causal effect of T2D on severe COVID-19. Genes with significant associations with both T2D and COVID-19 severe were enriched for biological pathways related to the response to type I interferon, glutathione derivative metabolism, and glutathione derivative biosynthesis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Immunology
Fan Cao, Yi-Sheng He, Yan Wang, Chen -Kai Zha, Jia-Min Lu, Li-Ming Tao, Zheng-Xuan Jiang, Hai-Feng Pan
Summary: This study aims to describe the burden of autoimmune diseases (ADs) including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), and psoriasis (PS), and explore the inequalities across countries with different sociodemographic development levels. Results show significant variations in the age-standardized DALYs rate and age and sex distribution of DALYs rate for the four ADs across 204 countries. The study utilizes slope index of inequality and concentration index to quantify the distributive inequalities in the burden of ADs.
AUTOIMMUNITY REVIEWS
(2023)
Article
Environmental Sciences
Jie Zhang, Xin-Yu Fang, Jun Wu, Yin-Guang Fan, Rui-Xue Leng, Bo Liu, Xiao-Jie Lv, Yu-Lu Yan, Chen Mao, Dong-Qing Ye
Summary: This study investigated the associations between various air pollutants and the risk of incident rheumatoid arthritis (RA) and further estimated the impact of combined exposure to ambient air pollutants on the risk of developing RA under the modification effect of genetic predisposition.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Review
Surgery
Yu-Chen Liu, Chuan-Lu Shen, Zi-Yue Fu, Yu-Chen Zhang, Yan-Xun Han, Bang-Jie Chen, Yuan Jiang, Si-Yue Yin, Zhi Tao, Shu-Yan Sheng, Jian-Peng Wang, Bing-Yu Liang, Liang Zhang, Dong Wang, Kai-Le Wu, Hai-Feng Pan, Ye-Hai Liu
Summary: The effectiveness of intraoperative nerve monitoring (IONM) in endoscopic thyroid surgery was explored in this study. The results showed that IONM significantly reduced the incidence of transient recurrent laryngeal nerve (RLN) palsy, but did not significantly reduce the incidence of permanent RLN palsy. However, there was a significant reduction in total RLN palsy. Additionally, IONM effectively reduced the localization time of the RLN and increased the identification rate of the superior laryngeal nerve. Therefore, the use of IONM is recommended for malignant tumors.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Environmental Sciences
Fan Cao, Zhuo-Ran Liu, Qin-Yu Ni, Chen-Kai Zha, Shu-Jie Zhang, Jia-Min Lu, Yue-Yang Xu, Li-Ming Tao, Zheng-Xuan Jiang, Hai-FenG Pan
Summary: Autoimmune eye diseases (AEDs) are a group of autoimmune inflammatory ocular conditions caused by immune system dysregulation at the ocular level, which can affect both intraocular and periorbital structures, leading to severe visual deficit and global blindness. The roles of air pollution and meteorological factors in the initiation and progression of AEDs have become increasingly attractive, with both systemic and local mechanisms involved. Exposure to excessive air pollution and extreme meteorological conditions can disturb the Th17/Treg balance, regulate macrophage polarization, activate neutrophils, induce systemic inflammation and oxidative stress, decrease retinal blood flow, promote tissue fibrosis, activate the sympathetic nervous system, adversely affect nutrient synthesis, and induce heat stress, which together may worsen AEDs. The interplay among inflammation, oxidative stress, and dysregulated immune system appears to be prominent. This review focuses on the potential mechanisms underlying the connections between air pollution and meteorological factors and ocular autoimmune and inflammatory responses. Furthermore, we concentrate on the specific roles of air pollutants and meteorological factors in several major AEDs including uveitis, Graves' ophthalmopathy (GO), ocular allergic disease (OAD), glaucoma, diabetic retinopathy (DR), etc.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biophysics
Guixia Pan, Jian Cheng, Hai-Feng Pan, Yin-Guang Fan, Dong-Qing Ye
Summary: This study aimed to assess the disease burden of chronic obstructive pulmonary disease (COPD) attributable to air pollution from multiple epidemiological perspectives. The results showed that in 2019, COPD deaths associated with air pollution accounted for 2.32% of global total deaths, and the disease-adjusted life years (DALY) accounted for 1.12% of global DALY. The number of COPD deaths associated with air pollution increased from 1990 to 2019, peaking at 1.41 million in 1993, and then declined. The burden of COPD associated with air pollution was also influenced by national indicators. Therefore, health policymakers are called to take action and interventions targeting vulnerable countries and populations.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Article
Environmental Sciences
Wuli Li, Xirun Zong, Yi-Sheng He, Xinpai Liu, Chunhui Zhao, Yuanyin Wang, Jing Zhang, Hai-Feng Pan
Summary: This study aimed to determine the impact of air pollution on the risk of periodontitis outpatient visits. A total of 56,456 periodontitis outpatient visits in Hefei, China, from January 1, 2014, to December 31, 2021, were analyzed. The findings suggest that NO2 exposure is associated with an increased risk of periodontitis outpatient visits, while O3 exposure is associated with a decreased risk. Season was found to modify these associations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Immunology
Yuchen Liu, Zhechen Wu, Ziyue Fu, Yanxun Han, Jianpeng Wang, Yanqiang Zhang, Bingyu Liang, Ye Tao, Yuchen Zhang, Chuanlu Shen, Yidan Xu, Siyue Yin, Bangjie Chen, Yehai Liu, Haifeng Pan, Zhang Liang, Kaile Wu
Summary: This study investigated focal adhesion-related genes (FARGs) in head and neck squamous cell carcinoma (HNSCC) and identified two molecular subtypes. A FARG signature model consisting of 9 genes was developed and proven to be a reliable prognostic predictor for HNSCC patients. Furthermore, FARGs were found to be associated with immune infiltration, gene mutation status, and chemosensitivity, providing potential targets for targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xi Fang, Cong Chen, Zhi-Xin Wang, Yan Zhao, Ling-Qiong Jiang, Yang Fang, Ruo-Di Zhang, Hai-Feng Pan, Sha-Sha Tao
Summary: The purpose of this study was to evaluate the serum Dickkopf-1 (DKK-1) level in ankylosing spondylitis (AS) patients compared to normal controls and to test the causal relationship between DKK-1 and AS risk. The meta-analysis of 40 studies showed no significant difference in DKK-1 serum level between AS patients and normal controls. The MR analysis also demonstrated no significant association between DKK-1 serum level and AS risk.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Cong Chen, Yi-Sheng He, Sha-Sha Tao, Yang Fang, Ruo-Di Zhang, Xi Fang, Ling-Qiong Jiang, Yan Zhao, Harry Asena Musonye, Jin-Hui Tao, Hai-Feng Pan
Summary: This study aimed to investigate the short-term correlation between meteorological factors and dermatomyositis (DM) outpatient visits. The findings showed significant associations between low temperature, humidity, diurnal temperature range, and temperature change and the risk of DM outpatient visits. Furthermore, women were more susceptible to high humidity and low temperature change, while the elderly were more susceptible to low temperature. In conclusion, exposure to low temperature, extreme humidity, and temperature changes (especially high diurnal temperature range and low temperature change) were associated with an increased risk of DM outpatient visits.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Yongrui Chen, Huiying Li, Guilin Qi, Tianxing Wu, Tenggou Wang
Summary: Query graph construction aims to generate a correct SPARQL query to answer natural language questions on a knowledge graph. Existing methods face challenges in handling complex questions including complicated SPARQL syntax, huge search space, and locally ambiguous query graphs. This paper proposes a novel end-to-end approach that leverages a unified graph grammar called AQG and hierarchical autoregressive decoding to construct query graphs effectively. Experimental results demonstrate that the proposed method significantly improves the state-of-the-art performance on complex KGQA benchmarks.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Environmental Sciences
Wuli Li, Xirun Zong, Yi-Sheng He, Tiantian Meng, Ying Tang, Qi Yang, Qing Huang, Yuanyin Wang, Song Li, Hai-Feng Pan
Summary: Evidence suggests a possible association between ambient air pollutants and oral diseases. The present study aimed to investigate the relationship between short-term exposure to air pollution and outpatient visits for pulpitis. The results showed that exposure to NO2, PM2.5, and CO were positively correlated with an increased risk of pulpitis outpatient visits, while exposure to O-3 was associated with a decreased risk. Age and season were found to be effect modifiers of these associations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
