Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Alginates are naturally occurring polymers revealing low toxicity, good biocompatibility and biodegradability, excellent gelling and thickening properties, as well as low production cost and good availability. One of the most important features typical for alginates is the ability to undergo ionotropic gelation which is gel formation process occurring upon the contact with cations. Because of their advantageous properties, alginates have been extensively utilized in food and pharmaceutical industries. In this review the current knowledge regarding the most recent studies involving both popularly applied dosage forms, like tablets or hydrogels, and novel advanced drug delivery systems applied in targeted therapies are summarized and discussed. The presented studies indicate that although sodium alginate is a well-established polymer, it is still widely applied as pharmaceutical excipient and the presented research studies indicate that there are still research areas that can be explored and provide innovation in drug delivery systems.(c) 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.

Automated summary

Alginates are naturally occurring polymers that possess low toxicity, good biocompatibility and biodegradability. They have been extensively used in the food and pharmaceutical industries. This review summarizes the ionotropic gelation properties of alginates and their applications in drug delivery systems.